Cancer Knowledge Network: First Live Births Less Common in Cancer Survivors

THE RESEARCH: Journal of Clinical Oncology:  Reproductive Patterns Among Childhood and Adolescent Cancer Survivors in Sweden: A Population-Based Matched-Cohort Study. Researchers in Sweden compared the probability of first live birth in 1,206 survivors of childhood cancers with 2,412 age-matched controls.  Previous studies assessing fertility outcomes in childhood cancer survivors have focused on treatment regimens, as opposed to diagnostic groups, and included survivors diagnosed over a wide span of time, some as far back as the 1950s. A potential limitation of these prior studies was the varied treatments of the survivors which included a wide array of chemotherapy and radiation doses.  Therefore, the primary aim of the Swedish study was to investigate the probability of first live birth in childhood and adolescent cancer survivors in a more contemporary cohort.  An additional aim was to evaluate findings with respect to the disease group, rather than by treatment exposures.

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Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on childhood cancer by discovering, developing, and disseminating new scientific knowledge. Our mission consists of three key areas — research, clinical, and education.

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