Cancer Knowledge Network: New Biomarker Predicts Late Neurocognitive Deficits in Adult Survivors of Childhood Leukemia

THE RESEARCH: Journal of the National Cancer Institute: Neurocognitive Sequelae in Adult Childhood Leukemia Survivors Related to Levels of Phosphorylated Tau. Researchers compared intellectual performance, memory, and executive functioning between 31 long-term adult survivors of childhood leukemia and 35 matched control subjects. In addition, correlations were evaluated between these cognitive outcomes and prior dose exposures to intrathecal methotrexate and with levels of phosphorylated Tau protein (p-Tau) in cerebrospinal fluid (CSF).

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

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