Journal of Clinical Oncology: Endocrine Abnormalities in Aging Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. Researchers in the United States analyzed the frequency of a range of endocrine disorders reported by 14,290 5-year survivors included in the Childhood Cancer Survivor Study (CCSS). Subjects included in the analysis had a median age at cancer diagnosis of 6 years and current median age of 32 years. Cumulative incidence and prevalence of endocrine orders was estimated and compared to previous therapeutic exposures. Comparisons were additionally made between survivors and age-matched controls. Endocrine disorders assessed included primary hypothyroidism, hyperthyroidism, thyroid neoplasms, hypopituitarism, obesity, diabetes mellitus, and gonadal dysfunction.
