Priscila Daniele Ramos Cirilo, Luciana Nogueira de Sousa Andrade, Bruna Renata Silva Corrêa, Mei Qiao, Tatiane Katsue Furuya, Roger Chammas, Luiz Otavio Ferraz Penalva
Background
Melanoma is the most lethal type of skin cancer. Since chemoresistance is a significant barrier, identification of regulators affecting chemosensitivity is necessary in order to create new forms of intervention. Prohibitin 1 (PHB1) can act as an anti-apoptotic or tumor suppressor molecule, depending on its subcellular localization. Our recent data have shown that the accumulation of PHB1 protects melanoma cells from chemotherapy-induced cell death. Lacking post-transcriptional regulation of PHB1 could explain this accumulation. Interestingly, most of the melanoma patients have down-regulation of microRNA-195. Here, we investigate the role of miR-195, its impact on PHB1 expression, and on chemosensitivity in melanoma cells.
