UT Health Newsroom: UT Health San Antonio researchers awarded $3 million for cancer studies

Ewing sarcoma research

Yuzuru Shiio, MD, PhD, of the Greehey Children’s Cancer Research Institute at UT Health San Antonio, was awarded $1.2 million to further studies of Ewing sarcoma, a pediatric bone and soft tissue cancer. The median age of Ewing sarcoma patients is 15 years, and more than half of patients are adolescents.

Dr. Shiio, associate professor of biochemistry and structural biology, and his laboratory discovered a novel signaling pathway in Ewing sarcoma. Inhibiting this pathway profoundly impairs cancer’s ability to proliferate, he said.

The CPRIT grant will help the team to understand the biological role and molecular mechanism of this pathway in Ewing sarcoma and evaluate whether it is feasible to target it for therapy.

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