Greehey CCRI Faculty Awarded $1.2M CPRIT Grant to Support Osteosarcoma Research

Rao & Gupta

Written by: Will Sansom

An award of $1.2 million from the Cancer Prevention and Research Institute of Texas (CPRIT) went to Greehey CCRI Deputy Director and principal investigator Manjeet Rao, Ph.D., professor of cell systems and anatomy, for studies of an enzyme protein that helps osteosarcoma cells to survive and spread.  The team, which includes co-principal investigator Yogesh Gupta, Ph.D., assistant professor of biochemistry and structural biology and member of the Greehey Institute, has identified a small molecule that can inhibit this activity. The goal of the CPRIT grant is to make this molecule more potent.

Osteosarcoma is a type of bone cancer in children. Over the last 30 years, no new drugs have been approved to treat it. This cancer typically develops before age 18 and can recur later in life. The survival rate for recurrent cancers that have metastasized or spread is under 20%.

Rao and Gupta’s grant is part of the $12.2M in CPRIT grants awarded to UT Health San Antonio during the current award cycle.

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