Texas Public Radio: Science & Medicine: Sabotaging the molecular engines of some pediatric cancers (Gupta)

February 24, 2025

 Ewing sarcoma and rhabdomyosarcoma are cancers that overwhelmingly impact children. They're soft tissue cancers that are thankfully rare because treatment options are limited, according to pediatric cancer researcher Yogesh Gupta, PhD, an associate professor at Greehey Children's Cancer Research Institute at UT Health San Antonio. “The drug treatment regimen has not been changed in the last three decades,” [...]

Kurmasheva Lab is Featured in CPRIT Annual Report

February 6, 2025

 Doctors diagnose nearly 1,200 Texans under 20 years of age with cancer every year. Despite intensive genotoxic therapy, nearly 20% of these children will die from their cancer. Those who survive face a lifetime of potential toxicities due to their therapy. CPRIT awarded a $4 million grant to The University of Texas Health Science Center [...]

In Memoriam: Sharon B. Murphy, MD (1943–2023)

December 15, 2023

 We share with great sadness that the inaugural director of the Greehey Children's Cancer Research Institute has passed.  Below is the obituary originally published in the American Society of Pediatric Hematology/Oncology on November 18, 2023.  She will always be remembered by those of us who were fortunate enough to work with her. It is an [...]

OpenAccessGovernment.org: Current and future therapy for BRAF-mutant pediatric glioma

November 20, 2023

 Professor Peter J. Houghton from the Greehey Children’s Cancer Research Institute discusses new approaches to pediatric cancer treatment, specifically for BRAF-mutant pediatric glioma. Low-grade glioma (LGG) is the most frequently diagnosed brain tumor in children, and although five and ten-year survival is quite high, this does not reveal the toxicity of current therapies. Conventional treatment includes intensive chemo-radiation [...]

Open Access Government: Developing novel therapies for childhood cancers (Houghton)

September 19, 2023

 Dr Peter J Houghton from Greehey Children’s Cancer Research Institute discusses the obstacles in developing new treatments for childhood cancers and new approaches in preclinical testing. In my previous article for Open Access Government, I focused on the challenges of developing novel therapies for children with glioma, the most prevalent brain cancer in children. Here, [...]

Texas Public Radio: “Fighting childhood cancer in San Antonio” (Aune)

September 8, 2023

 September is Childhood Cancer Awareness Month, a time to raise awareness of this devastating disease and to support the children and families who are affected by it. Childhood cancer is the leading cause of death by disease for children under the age of 14. Each year, about 15,000 children in the United States are diagnosed [...]

Dr. Gupta to Present at Cold Spring Harbor Laboratory Meeting on Eukaryotic mRNA Processing, August 22-26, 2023

August 2, 2023

 Click on image below for full agenda _________________________________________________________ Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on [...]

Panneerdoss Subbarayalu, PhD, to receive NIH, NCI R21 Grant, “Targeting the RNA Modifying Enzyme ALKBH5 in Medulloblastoma

June 5, 2023

 Project Title: Targeting the RNA modifying enzyme ALKBH5 in Medulloblastoma Principal Investigator: Panneerdoss Subbarayalu Co-Investigators: Manjeet Rao, PhD, Andrew Brenner, MD, PhD., Peter Houghton, PhD. Funding Agency: National Institutes of Health, NATIONAL CANCER INSTITUTE Medulloblastoma is the most common malignant brain cancer in children. Despite the progress in treating medulloblastoma, the 5-year survival rate for high-risk [...]