Genome Biology: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation (Bishop & Penalva Labs)
Adam Kosti 1 2, Patricia Rosa de Araujo 1 2, Wei-Qing Li 1 3, Gabriela D A Guardia 4, Jennifer Chiou 5, Caihong Yi 1, Debashish Ray 6, Fabiana Meliso 4, Yi-Ming Li 3, Talia Delambre 1, Mei Qiao 1, Suzanne S Burns 1, Franziska K Lorbeer 1, Fanny Georgi 1, Markus Flosbach 1, Sarah Klinnert 1, Anne Jenseit 1, Xiufen Lei 1, Carolina Romero Sandoval 1, Kevin Ha 6, Hong Zheng 6, Renu Pandey 1, Aleksandra Gruslova 7, Yogesh K Gupta 1, Andrew Brenner 8, Erzsebet Kokovay 2, Timothy R Hughes 6 9 10, Quaid D Morris 6 9 11, Pedro A F Galante 12, Stefano Tiziani 13, Luiz O F Penalva 14 15
Abstract
Background: RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification and characterization of oncogenic RBPs and their regulatory networks provide new opportunities for targeted therapy.
