Structure: Order and disorder bound together in SARS-CoV-2 Nsp1 suppress host translation (Libich Lab)

Abstract

In this issue of Structure, Wang et al. investigate the interplay between folded and disordered regions of the SARS-CoV-2 non-structural protein 1 (Nsp1) that promotes the suppression of host protein translation. Their investigation will lead to novel avenues to target critical viral functions necessary for host immune-response suppression therapeutically.

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