Research Paper

MDPI: Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion (Houghton)

September 28, 2021

Roxane R. Lavoie Patricio C. Gargollo Mohamed E. Ahmed Yohan Kim Emily Baer Doris A. Phelps Cristine M. Charlesworth Benjamin J. Madden Liguo Wang Peter J. Houghton John Cheville Haidong Dong Candace F. Granberg Fabrice Lucien Simple Summary Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children, and there is a critical need to […]


Journal of Virology: MULTIPLEXED SIV-SPECIFIC PAIRED RNA-GUIDED CAS9 NICKASES INACTIVATE PROVIRAL DNA (Lai)

September 23, 2021

Authors: Lisa M Smith, Jason T. Ladner, Vida L. Hodara, Laura M. Parodi, R. Alan Harris, Jessica E. Callery, Zhao Lai, Yi Zou, Muthuswamy Raveedran, Jeffrey Rogers, and Luis D. Giavedoni Abstract Human and simian immunodeficiency virus infections establish a lifelong reservoir of cells harboring an integrated proviral genome. Genome editing CRISPR-associated Cas9 nucleases, combined […]


Cambridge Core: Examining Access to Care in Clinical Genomic Research and Medicine: Experiences from the CSER Consortium (Tomlinson)

September 21, 2021

Amanda M. Gutierrez[Opens in a new windo Jill O. Robinson, Simon M. Outram, Hadley S. Smith, Stephanie A. Kraft, Katherine E. Donohue, Barbara B. Biesecker, Kyle B. Brothers, Flavia Chen, Benyam Hailu, Lucia A. Hindorff, Hannah Hoban, Rebecca L. Hsu, Sara J. Knight, Barbara A. Koenig, Katie L. Lewis, Kristen Hassmiller Lich, Julianne M. O’Daniel, […]


MDPI: Design and Characterization of a Cell-Penetrating Peptide Derived from the SOX2 Transcription Factor (Blancafort)

September 10, 2021

Neha S. Gandhi Edina Wang Anabel Sorolla Yu Jie Kan Adil Malik Jyotsna Batra Kimberly A. Young Wan Jun Tie Pilar Blancafort Ricardo L. Mancera Abstract SOX2 is an oncogenic transcription factor overexpressed in nearly half of the basal-like triple-negative breast cancers associated with very poor outcomes. Targeting and inhibiting SOX2 is clinically relevant as […]


European Journal of Cancer: Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: A systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group (Aune)

September 9, 2021

Elvira C.van Dalena Renée L.Muldera EugeneSuhb Matthew J.Ehrhardtc Gregory J.Auned EditBardief Bradley J.Bensong JuttaBergler-Kleinh Ming H.Cheni EvaFreyf UlrikeHennewigj LianeLockwoodk UllaMartinssonl  MonicaMuracam  Helenavan der Pala  ChrisPlummern  KatrinScheinemannopq  ChristinaSchinderars  Daniel A.Mulrooneyc Highlights • Cancer survivors are at risk for premature coronary artery disease (CAD). • Especially survivors treated with radiotherapy exposing the heart. • This guideline provides […]


Cancer Research: SNAI2-mediated repression of BIM protects rhabdomyosarcoma from ionizing radiation (Houghton, Ignatius, & Zheng Labs)

August 31, 2021

Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton and Myron S. Ignatius Abstract Ionizing radiation (IR) and chemotherapy are mainstays of treatment for patients with rhabdomyosarcoma (RMS), yet the molecular mechanisms that underlie the success or failure of radiotherapy remain unclear. The transcriptional repressor SNAI2 was previously identified as a key regulator of IR sensitivity in […]


Frontiers in Immunolgy: Manipulating the NKG2D Receptor-Ligand Axis Using CRISPR: Novel Technologies for Improved Host Immunity (Blancafort)

August 30, 2021

Eric Alves1,2*,Emily McLeish3,Pilar Blancafort1,2,4,Jerome D. Coudert3,5,6†Silvana Gaudieri1,7,8† Abstract The activating immune receptor natural killer group member D (NKG2D) and its cognate ligands represent a fundamental surveillance system of cellular distress, damage, or transformation. Signaling through the NKG2D receptor-ligand axis is critical for early detection of viral infection or oncogenic transformation and the presence of functional […]


Pediatric Blood & Cancer: In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC) (Kurmasheva, Houghton)

August 30, 2021

Raushan T. Kurmasheva, Stephen W. Erickson, Ruolan Han, Beverly A. Teicher, Malcolm A. Smith, Michael Roth, Richard Gorlick, Peter J. Houghton Abstract SP-2577(Seclidemstat), an inhibitor of lysine-specific demthylase KDM1A (LSD1) that is overexpressed in pediatric sarcomas, was evaluated against pediatric sarcoma xenografts. SP-2577 (100 mg/kg/day × 28 days) statistically significantly (p < .05) inhibited the growth of three of eight Ewing sarcoma (EwS), four […]


European Journal of Cancer: Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: A systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group (Aune)

August 30, 2021

Elvira C.van Dalena, Renée L.Muldera, EugeneSuhb, Matthew J.Ehrhardtc, Gregory J.Auned, Edit Bardief, Bradley J.Bensong, JuttaBergler-Kleinh, Ming H.Cheni, EvaFreyf, UlrikeHennewigj, LianeLockwoodk, UllaMartinssonl, MonicaMuracam, Helenavan der Pala, ChrisPlummern, KatrinScheinemannopq, ChristinaSchinderars, Emily S.Tonorezost, W. HamishWallaceu, Louis S.Constinev, RoderickSkinnerw, Melissa M.Hudsonc, Leontien C.M.Kremerax, GillLevitty1, Daniel A.Mulrooneyc Abstract Background Coronary artery disease (CAD) is a concerning late outcome for cancer survivors. […]


Biomolecular NMR Assignments: The 1H, 15N and 13C resonance assignments of the C‑terminal domain of Serpine mRNA binding protein 1 (SERBP1), (Libich Lab)

August 30, 2021

Antoine Baudin, Xiaoping Xu & David S. Libich Abstract SERBP1 is a multifunctional mRNA-binding protein that has been shown to play a regulatory role in a number of biological processes such as thrombosis, DNA damage repair, and the cellular response to nutrient deprivation. Additionally, SERBP1 is upregulated in glioblastoma, leukemia as well as liver, prostrate and […]