ELife: Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing (Rao, Gupta, et al)
February 11, 2025
Abstract The nuclear METTL3-METTL14 transfers a methyl group from SAM to convert the N6 of adenosine (A) in RNA to m6A and in ssDNA to 6mA. m6A marks are prevalent in eukaryotic mRNAs and lncRNAs and modulate their stability and fate in a context-dependent manner. The cytoplasmic METTL3 can act as a m6A reader. However, the precise [...]