BioPhysics Journal: Unraveling the phase separation of EWS low complexity domain using molecular dynamics simulations (Libich Lab)
Kandarp A. Sojitra 1, Courtney Johnson 2 3, Erich Sohn 2 3, David Libich 2 3, Jeetain Mittal 1
EWS, an RNA-binding protein, is responsible for gene expression, cell signaling, RNA processing, and transport. It is a member of the FET (FUS, EWS, TAF15) family, whose derailed phase separation is known to cause many neurodegenerative diseases. Through achromosomal translocation, the low complexity domain (LCD) of EWS may be fused to the DNA binding domain of the transcription factor FLI1.