Cancer Research: EpCAM and α-Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma

March 1, 2008

Taro Yamashita, Marshonna Forgues, Wei Wang, Jin Woo Kim, Qinghai Ye, Huliang Jia, Anuradha Budhu, Krista A. Zanetti, Yidong Chen, Lun-Xiu Qin, Zhao-You Tang, and Xin Wei Wang Abstract The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Recently, we have identified that a hepatic stem cell marker, epithelial cell adhesion molecule (EpCAM), may serve as an early biomarker of HCC because its expression is highly elevated in […]

Pediatric Blood & Cancer: Treatment of Wilms tumor relapsing after initial treatment with vincristine, actinomycin D, and doxorubicin. A report from the National Wilms Tumor Study Group

February 1, 2008

Marcio Malogolowkin 1, Cecilia A Cotton, Daniel M Green, Norman E Breslow, Elizabeth Perlman, James Miser, Michael L Ritchey, Patrick R M Thomas, Paul E Grundy, Giulio J D’Angio, J Bruce Beckwith, Robert C Shamberger, Gerald M Haase, Milton Donaldson, Robert Weetman, Max J Coppes, Patricia Shearer, Peter Coccia, Morris Kletzel, Roger Macklis, Gail Tomlinson, Vicki Huff, Robert Newbury, Douglas Weeks, National Wilms Tumor Study Group Abstract Objective: We evaluated the use of alternating cycles of cyclophosphamide/etoposide and carboplatin/etoposide in children […]

Neoplasia: Comparison of Expression Profiles of Metastatic versus Primary Mammary Tumors in MMTV-Wnt-1 and MMTV-Neu Transgenic Mice1

February 1, 2008

Author links open overlay panelShixia Huang*†‡, Yidong Chen§, Katrina Podsypanina Abstract Distant metastases of human breast cancers have been suggested to be more different from each other than from their respective primary tumors, based on expression profiling. The mechanism behind this lack of similarity between individual metastases is not known. We used cDNA microarrays to […]

Cancer Research: RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers

January 1, 2008

Boning Gao 1, Xian-Jin Xie, Chunxian Huang, David S Shames, Tina T-L Chen, Cheryl M Lewis, Aihua Bian, Bifeng Zhang, Olufunmilayo I Olopade, Judy E Garber, David M Euhus, Gail E Tomlinson, John D Minna Abstract The tumor suppressor gene RASSF1A regulates cell cycle progression, apoptosis, and microtubule stability and is inactivated by promoter methylation in approximately 50% of breast cancers. It has been shown previously that the […]

Clinical Breast Cancer: Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a prospective cohort of unaffected BRCA1 and BRCA2 mutation carriers

December 1, 2007

Tara M Friebel 1, Susan M Domchek, Susan L Neuhausen, Theresa Wagner, D Gareth Evans, Claudine Isaacs, Judy E Garber, Mary B Daly, Rosalind Eeles, Ellen Matloff, Gail Tomlinson, Henry T Lynch, Nadine Tung, Joanne L Blum, Jeffrey Weitzel, Wendy S Rubinstein, Patricia A Ganz, Fergus Couch, Timothy R Rebbeck Abstract Background: Women with BRCA1 or BRCA2 (BRCA1/2) mutations can reduce cancer incidence and mortality by using bilateral prophylactic oophorectomy (BPO) or bilateral prophylactic mastectomy […]

Molecular Cancer Research: Mouse Embryo Fibroblasts Lacking the Tumor Suppressor Menin Show Altered Expression of Extracellular Matrix Protein Genes

October 1, 2007

Abstract Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized primarily by endocrine tumors of the parathyroids, anterior pituitary, and enteropancreatic endocrine tissues. Affected individuals carry a germ-line loss-of-function mutation of the MEN1 gene, and tumors arise after the loss of the second allele. Homozygous loss of Men1 in the germline of […]

Cancer Biology & Therapy: Silencing of lactotransferrin expression by methylation in prostate cancer progression

July 11, 2007

Syed Shaheduzzaman, Anu Vishwanath, Bungo Furusato, Jennifer Cullen, Yongmei Chen, Lionel Bañez, Martin Nau, Lakshmi Ravindranath, Kee-Hong Kim, Ahmed Mohammed, Yidong Chen, Mathias Ehrich, Vasantha Srikantan, Isabell A. Sesterhenn, David G. McLeod, Maryanne Vahey,Gyorgy Petrovics,Albert Dobi &Shiv Srivastava Abstract Background: Cancer cells gain selection advantages by the coordinated silencing of protective and by the activation of […]

Advances in Genetics: Involvement of Homologous Recombination in Carcinogenesis

April 21, 2007

Author links open overlay panelRamuneReliene* Alexander J.R.Bishop §Robert H.Schiestl*†‡ Abstract DNA alterations of every type are associated with the incidence of carcinogenesis, often on the genomic scale. Although homologous recombination (HR) is an important pathway of DNA repair, the evidence is accumulating that deleterious genomic rearrangements can result from HR. It, therefore, follows that HR events may play […]

UT Health SA Newsroom: UTHSC, community celebrate Greehey gift

April 7, 2007

Published On: April 17, 2007 Shared by Will Sansom San Antonio (April 17, 2007) – A chain of people – including an adolescent cancer survivor, a medical student, a research fellow, and a physician and scientist – symbolized the impact of The Greehey Family Foundation’s $25 million gift to The University of Texas Health Science Center […]