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Molecular Cancer Research: Mouse Embryo Fibroblasts Lacking the Tumor Suppressor Menin Show Altered Expression of Extracellular Matrix Protein Genes
October 1, 2007
Abstract Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized primarily by endocrine tumors of the parathyroids, anterior pituitary, and enteropancreatic endocrine tissues. Affected individuals carry a germ-line loss-of-function mutation of the MEN1 gene, and tumors arise after the loss of the second allele. Homozygous loss of Men1 in the germline of […]
Cancer Biology & Therapy: Silencing of lactotransferrin expression by methylation in prostate cancer progression
July 11, 2007
Syed Shaheduzzaman, Anu Vishwanath, Bungo Furusato, Jennifer Cullen, Yongmei Chen, Lionel Bañez, Martin Nau, Lakshmi Ravindranath, Kee-Hong Kim, Ahmed Mohammed, Yidong Chen, Mathias Ehrich, Vasantha Srikantan, Isabell A. Sesterhenn, David G. McLeod, Maryanne Vahey,Gyorgy Petrovics,Albert Dobi &Shiv Srivastava Abstract Background: Cancer cells gain selection advantages by the coordinated silencing of protective and by the activation of […]
Advances in Genetics: Involvement of Homologous Recombination in Carcinogenesis
April 21, 2007
Author links open overlay panelRamuneReliene* Alexander J.R.Bishop §Robert H.Schiestl*†‡ Abstract DNA alterations of every type are associated with the incidence of carcinogenesis, often on the genomic scale. Although homologous recombination (HR) is an important pathway of DNA repair, the evidence is accumulating that deleterious genomic rearrangements can result from HR. It, therefore, follows that HR events may play […]
UT Health SA Newsroom: UTHSC, community celebrate Greehey gift
April 7, 2007
Published On: April 17, 2007 Shared by Will Sansom San Antonio (April 17, 2007) – A chain of people – including an adolescent cancer survivor, a medical student, a research fellow, and a physician and scientist – symbolized the impact of The Greehey Family Foundation’s $25 million gift to The University of Texas Health Science Center […]
Clinical Cancer Research: Gene Expression Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma
February 1, 2007
Hu-Liang Jia, Qing-Hai Ye, Lun-Xiu Qin, Anuradha Budhu, Marshonna Forgues, Yidong Chen, Yin-Kun Liu, Hui-Chuan Sun, Lu Wang, Hong-Zhou Lu, Fang Shen, Zhao-You Tang and Xin Wei Wang Abstract Purpose: Hepatocellular carcinoma (HCC), common cancer worldwide, has a dismal outcome partly due to the poor identification of early-stage HCC. Currently, one-third of HCC patients present with low serum α-fetoprotein (AFP) levels, the only clinically available diagnostic marker for HCC. The aim of this study was to identify new diagnostic molecular markers […]
Technology in Cancer Research & Treatment: Wnt-1 is Dominant over Neu in Specifying Mammary Tumor Expression Profiles
December 1, 2006
Shixia Huang, PhD*, Katrina Podsypanina, PhD, Yidong Chen, PhD, Weiyan Cai, Anna Tsimelzon, PhD, Susan Hilsenbeck, PhD, Yi Li, PhD Abstract Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both MMTV-Wnt-1 and MMTV-Neu. In this report, gene expression profiles were determined for tumors from these bitransgenic mice and compared with expression profiles of tumors from mice singly transgenic for MMTV-Wnt-1 or MMTV-Neu. While very different from tumors arising […]
Nature Methods: Sensitive and specific method for detecting G protein–coupled receptor mRNAs
November 19, 2006
Arne Hansen, Yidong Chen, Jason M Inman, Quang N Phan, Zhi-Qing Qi, Charlie C Xiang, Miklos Palkovits, Natasha Cherman, Sergei A Kuznetsov, Pamela G Robey, Eva Mezey & Michael J Brownstein Abstract G protein-coupled receptors (GPCRs) mediate the effects of extracellular signaling molecules in all the body’s cells. These receptors are encoded by scarce mRNAs; therefore, detecting their transcripts with conventional microarrays is difficult. We present a […]
The American Journal of Pathology: A Novel Role of Myosin VI in Human Prostate Cancer
November 1, 2006
Thomas A.Dunn*, Shenglin Chen*, Dennis A.Faith†, Jessica L.Hicks† Elizabeth A.Platz*‡, Yidong Chen§, Charles M.Ewing*, Jurga Sauvageot*, William B.Isaacs*†, Angelo M.De Marzo*†, Jun, Luo* Myosin VI is an actin motor that moves to the minus end of the polarized actin filament, a direction opposite to all other characterized myosins. Using expression microarrays, we identified myosin VI as one of the top […]
Cancer Cell: Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
August 1, 2006
Author links open overlay panelAnuradha Budhu1, Marshonna Forgues1, Qing-HaiYe2, Hu-Liang Jia12, Ping He3, Krista A.Zanetti4, Udai S.Kammula5, Yidong Chen6, Lun-XiuQin2, Zhao-YouTang2, Xin WeiWang1 Summary Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or postsurgical recurrence. We postulate that metastases are influenced by liver microenvironment. Here, we show that a unique inflammation/immune response-related signature is […]
Fertility and Sterility: Identification of molecular markers for endometriosis in blood lymphocytes by using deoxyribonucleic acid microarrays
June 1, 2006
Idhaliz FloresPhDa Elizabeth RiveraM.Ed.a Spyro MoussesPhDb Yidong ChenPhDc Ester RozenblumPhDd Objective To identify molecular biomarkers for endometriosis in peripheral blood lymphocytes by using DNA microarrays. Design Case-control. Setting Multicenter academic research programs. Patient(s) Premenopausal women with or without endometriosis, determined by obstetrics and gynecology specialists during surgery. Microarray analysis included six endometriosis patients and five controls; 15 endometriosis patients and 15 controls were analyzed […]