Category
February 27, 2011
Alison Claybon1, Alexander J. R. Bishop1 Abstract The retinal pigment epithelium (RPE) lies at the back of the mammalian eye, just under the neural retina, which contains the photoreceptors (rods and cones). The RPE is a monolayer of pigmented cuboidal cells and associates closely with the neural retina just above it. This association makes the RPE […]
February 1, 2011
Brian P.Rubin1, KoichiNishijo2, Hung-I HarryChen2, XiaolanYi2, David P.Schuetze1, RanadipPal3, Suresh I.Prajapati2, JinuAbraham2, Benjamin R.Arenkiel4, Qing-RongChen5, SeanDavis6, Amanda T.McCleish2, Mario R.Capecchi7, Joel E.Michalek8, Lee AnnZarzabal8, JavedKhan5, ZhongxinYu9, David M.Parham9, CharlesKeller2111213 Summary Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation among sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53, and/or Rb1 conditional mouse models and controlling prenatal or postnatal myogenic cell […]
January 28, 2011
Liqin Du, Alexander Pertsemlidis Abstract Although cancer and neurodegenerative disease are two distinct pathological disorders, emerging evidence indicates that these two types of disease share common mechanisms of genetic and molecular abnormalities. Recent studies show that individual microRNAs (miRNAs) could be involved in the pathology of both diseases, indicating that the mechanisms of these two seemingly […]
January 10, 2011
Dashnamoorthy Ravi, Yidong Chen, Bijal Karia, Adam Brown, Ting Ting Gu, Jie Li, Mark S. Carey, Bryan T. Hennessy, Abstract Background In vitro cell, culture experiments with primary cells have reported that cell proliferation is retarded in the presence of ambient compared to physiological O2 levels. Cancer is primarily a disease of aberrant cell proliferation, therefore, studying cancer cells grown under ambient O2 may […]
January 1, 2011
Jennifer A Minnix 1, Jason D Robinson, Cho Y Lam, Brian L Carter, Jennifer E Foreman, David J Vandenbergh, Gail E Tomlinson, David W Wetter, Paul M Cinciripini Abstract Affective startle probe methodology was used to examine the effects of nicotine administration and deprivation on emotional processes among individuals carrying at least one s allele versus those with the l/l genotype of the 5-Hydroxytryptamine […]
January 1, 2011
Sharon E Plon 1, David A Wheeler, Louise C Strong, Gail E Tomlinson, Michael Pirics, Qingchang Meng, Hannah C Cheung, Phyllis R Begin, Donna M Muzny, Lora Lewis, Jaclyn A Biegel, Richard A Gibbs Erratum in Cancer Genet. 2011 May;204(5):284 Abstract Clinical cancer genetic susceptibility analysis typically proceeds sequentially, beginning with the most likely causative gene. The process is time-consuming and the yield is low, particularly for [...]December 1, 2010
Antonis C Antoniou 1, Jonathan Beesley, Lesley McGuffog, Olga M Sinilnikova, Sue Healey, Susan L Neuhausen, Yuan Chun Ding, Timothy R Rebbeck, Jeffrey N Weitzel, Henry T Lynch, Claudine Isaacs, Patricia A Ganz, Gail Tomlinson, Olufunmilayo I Olopade, Fergus J Couch, Xianshu Wang, Noralane M Lindor, Vernon S Pankratz, Paolo Radice, Siranoush Manoukian, Bernard Peissel, Daniela Zaffaroni, Monica Barile, Alessandra Viel, Anna Allavena, Valentina Dall’Olio, Paolo Peterlongo, Csilla I Szabo, Michal Zikan, Kathleen Claes, Bruce Poppe, Lenka Foretova, Phuong L Mai, Mark H Greene, Gad Rennert, Flavio Lejbkowicz, Gord Glendon, Hilmi Ozcelik, Irene L […]
December 1, 2010
Jia Meng, Mingzhu Lu, Yidong Chen, Shou-Jiang Gao & Yufei Huang Abstract Background The response of cells to changing endogenous or exogenous conditions is governed by intricate molecular interactions or regulatory networks. To lead to appropriate responses, the regulatory network should be 1) context-specific, i.e., its constituents and topology depend on the phenotypical and experimental context including tissue types and […]
December 1, 2010
Hui Liu, Dong Yue, Lin Zhang, Yidong Chen, Shou-Jiang Gao & Yufei Huang Abstract Background MicroRNAs (miRNAs) are single-stranded non-coding RNAs shown to plays important regulatory roles in a wide range of biological processes and diseases. The functions and regulatory mechanisms of most miRNAs are still poorly understood in part because of the difficulty in identifying the miRNA regulatory targets. To […]
November 27, 2010
Yuan Chun Ding 1, Linda Steele, Li-Hao Chu, Karen Kelley, Helen Davis, Esther M John, Gail E Tomlinson, Susan L Neuhausen Abstract Breast cancer incidence is lower in African Americans than in Caucasian Americans. However, African-American women have higher breast cancer mortality rates and tend to be diagnosed with the earlier-onset disease. Identifying factors correlated to the racial/ethnic variation in the epidemiology of […]