Cancers: Global Genomic and Proteomic Analysis Identified Critical Pathways Modulated by Proto-Oncogene PELP1 in TNBC (Chen & Lai)

February 25, 2022

 by Zexuan Liu 1,2,†,Kristin A. Altwegg 1,3,†ORCID,Junhao Liu 1,2,Susan T. Weintraub 4,Yidong Chen 5,6,Zhao Lai 5,7,Gangadhara R. Sareddy 1,3,Suryavathi Viswanadhapalli 1,3,*ORCID and Ratna K. Vadlamudi 1,3,8,* Simple Summary The proto-oncogene PELP1 is commonly overexpressed in many cancers including triple-negative breast cancer (TNBC). In this study, we utilized global proteomic and RNA-seq approaches to elucidate the [...]

Journal of Pediatric Hematology/Oncology: Extrarenal Anaplastic Wilms Tumor A Case Report With Genomic Analysis And Tumor Models (Kurmasheva & Houghton)

February 8, 2022

 Willis, Kelsi R. MS*; Sathe, Adwait A. PhD†; Xing, Chao PhD†,‡,§; Koduru, Prasad PhD*; Artunduaga, Maddy MD∥,¶; Butler, Erin B. MD#; Park, Jason Y. MD, PhD*,¶; Kurmasheva, Raushan T. PhD**,††; Houghton, Peter J. PhD**,††; Chen, Kenneth S. MD¶,#; Rakheja, Dinesh MD*,¶ Abstract Primary extrarenal Wilms tumors are rare neoplasms that are presumed to arise from [...]

Brain, Behavior, & Immunity: Sex-dependent pain trajectories induced by prolactin require an inflammatory response for pain resolution (Lai Lab)

January 24, 2022

 Author links open overlay panelJenniferMecklenburga  AndiWangzhouf  Anahit H.Hovhannisyana  PriscillaBarba-Escobedoa  Sergey A.Sheinb  YiZoud  KorriWeldond  ZhaoLaideVincentGoffing  GregoryDussorf  Alexei V.Tumanovb  Theodore J.Pricef  Armen N.Akopianac   Highlights: • Prolactin treatment generates sex differences in pain trajectories in mice. • Low-dose prolactin treatment causes a non-resolving pain phenotype in females. • Pain resolution is preceded by pro-inflammatory CD11b+/CD64+ cell responses. • [...]

eLife: RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro (Gupta Lab)

January 21, 2022

 Shan Qi,  Javier Mota,  Siu-Hong Chan,  Johanna Villarreal,  Nan Dai,  Shailee Arya,  Robert A Hromas,  Manjeet K Rao,  Ivan R Corrêa Jr  Yogesh K Gupta  Abstract Methyltransferase like-3 (METTL3) and METTL14 complex transfer a methyl group from S-adenosyl-L-methionine to N6 amino group of adenosine bases in RNA (m6A) and DNA (m6dA). Emerging evidence highlights the role of [...]

Frontiers in Microbiology: Robust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor (Lai Lab)

January 20, 2022

 Yehong Huang1,2†, Wurihan Wurihan2†, Bin Lu1,2†, Yi Zou3, Yuxuan Wang2†, Korri Weldon3, Joseph D. Fondell2†, Zhao Lai3,4, Xiang Wu1*†, and Huizhou Fan2*† Cells reprogram their transcriptome in response to stress, such as heat shock. In free-living bacteria, the transcriptomic reprogramming is mediated by increased DNA-binding activity of heat shock sigma factors and activation of genes normally repressed [...]

Frontiers in Genetics: Differential lncRNA/mRNA Expression Profiling and Functional Network Analyses in Bmp2 Deletion of Mouse Dental Papilla Cells (Lai Lab)

January 20, 2022

 Feng Wang1,2†, Ran Tao1†, Li Zhao1, Xin-Hui Hao1, Yi Zou3, Qing Lin1, Meng Meng Liu2, Graham Goldman2, Daoshu Luo1* and Shuo Chen2* Bmp2 is essential for dentin development and formation. Bmp2 conditional knock-out (KO) mice display a similar tooth phenotype of dentinogenesis imperfecta (DGI). To elucidate a foundation for subsequent functional studies of cross-talk between [...]

iScience: SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics (Aune)

January 19, 2022

 Karthik Ramachandran110 Soumya Maity110  Alagar R.Muthukumar2  Soundarya Kandala1  Dhanendra Tomar3  Tarek Mohamed Abd El-Aziz49  Cristel Allen1  Yuyang Sun5  Manigandan Venkatesan1  Travis  R.Madaris1  Kevin Chiem6  RachelTruitt7  Neelanjan Vishnu1  Gregory Aune8 Allen Anderson1 Luis Martinez6  Wenli Yang7  James D.Stockand3  Brij B.Singh5  Subramanya Srikantan1 W. BrianReeves1  Muniswamy Madesh111 Highlights • SARS-CoV-2 perturbs human ion channel, quality control, and [...]

Urologic Oncology: Prevalence of pathogenic germline cancer risk variants in testicular cancer patients: Identifying high risk groups (Tomlinson)

January 19, 2022

 ChethanRamamurthyM.D.a‡Amin H.NassarM.D.bc‡SarahAbou AlaiwiM.D.bcElioAdibM.D.bcElie W.AklM.D.cShanYangPh.D.dEdward D.EsplinM.D., Ph.D.dMichael A.LissM.D.aGail E.TomlinsonM.D.eGuru P.SonpavdeM.D.b Highlights • Testicular cancer patients are at risk for carrying germline pathogenic variants. • Risk factors for germline variants include having another primary malignancy or a family history of testicular cancer. • A subset of patients with testicular cancer may particularly benefit from genetic evaluation. Abstract Background [...]

iScience: PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma (Kurmasheva & Houghton Labs)

January 18, 2022

 Vanessa del Pozo Andrew J.Robles Shaun D.Fontaine QianqianLiu Joel E.Michalek Peter J.Houghton Raushan T.Kurmasheva Highlights Nanoparticle-formulated drugs minimize drug-induced toxicity PEG∼TLZ enhances in vivo activity of TMZ in pediatric tumor xenografts A 3-day interval between each drug's administration widens the therapeutic window A single IV dose of PEG∼TLZ is advantageous for treating infants/young children Summary [...]