Research Paper
Cancer Letters: KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer (Lai & Chen Labs)
October 28, 2021
Prabhakar PittaVenkataa1 YihongChenab1 SalvadorAlejoa YiHeab Bridgitte E.Palaciosa IlannaLoeffela JunhaoLiuacUday P.Pratapa GabrielleGraya Sureshkumar MulampurathAchuthan Pillaia YiZoud ZhaoLaideT akayoshiSuzukif SuryavathiViswanadhapallia SrinathPalakurthig Rajeshwar R.Tekmalah Ratna K.Vadlamudiahi EdwardKosta Gangadhara R.Sareddyah Highlights • From the drug screen, we found that KDM1A inhibition is highly synergistic with mTOR inhibitors. • KDM1A inhibition attenuated the mTOR signaling cascade and abolished rapamycin-induced feedback [...]Molecular Cancer Research: GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer (Chen)
October 27, 2021
Marieke Burleson, Janice J. Deng, Tai Qin, Thu Minh Duong, Yuqian Yan, Xiang Gu, Debodipta Das, Acarizia Easley, Michael A. Liss, P. Renee Yew, Roble Bedolla, Addanki Pratap Kumar, Tim Hui-Ming Huang, Yi Zou, Yidong Chen, Chun-Liang Chen, Haojie Huang, Lu-Zhe Sun and Thomas G. Boyer Abstract Although the Sonic hedgehog (SHH) signaling pathway has been implicated in promoting malignant phenotypes of prostate cancer, details on how it is activated and exerts its oncogenic role during prostate cancer development and progression are less clear. Here, we show that GLI3, a key SHH pathway [...]Free Radical Biology and Medicine: Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer (Bishop Lab)
October 26, 2021
MarinaDelgoboa Rosângela MayerGonçalvesag Marco AntônioDelazerib MarceloFalchettia AlessandroZandonáb RaquelNascimento das Nevesa KarolineAlmeidaa Adriane CristinaFagundesa Daniel PensGelainc João IsidroFracassod Guilherme Baroni deMacêdod LeonardoPriorid NicklasBassanie Alexander James RoyBishopef Cassiano MateusForcelinib José Cláudio FonsecaMoreirac1 AlfeuZanotto-Filhoa1 Highlights • Amid 64 redox genes, TXNRD1 shows association with poor survival in NSCLC. • High TXNRD1 levels predict poor DFS and DMFS in [...]JoVE: Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins (Libich Lab)
October 13, 2021
Courtney N. Johnson1, David S. Libich1 Abstract Intrinsically disordered proteins and intrinsically disordered regions within proteins make up a large and functionally significant part of the human proteome. The highly flexible nature of these sequences allows them to form weak, long-range, and transient interactions with diverse biomolecular partners. Specific yet low-affinity interactions promote promiscuous binding [...]Frontiers in Molecular BioScience: Structural Characterization of the RNA-Binding Protein SERBP1 Reveals Intrinsic Disorder and Atypical RNA Binding Modes (Libich & Penalva labs)
October 13, 2021
Antoine Baudin, 1 , 2 , † Alma K. Moreno-Romero, 1 , 2 Xiaoping Xu, 1 , 2 Emily E. Selig, 1 , 2 , † Luiz O. F. Penalva, 1 , 3 and David S. Libich 1 , 2 ,* † Abstract RNA binding proteins (RBPs) are essential for critical biological processes such as translation regulation and mRNA processing, and misfunctions of these proteins are associated with diseases such as cancer and neurodegeneration. SERBP1 (SERPINE1 [...]Journal of Palliative Medicine: When a Tumor Becomes a Legacy: A Collection of Perspectives (Ignatius & Tomlinson Labs)
October 4, 2021
Amanda E. Lipsitt, Patricia K. DeForest, Andrea J. Canon, Andrea R. Gilbert, and Gail E. Tomlinson Introduction The following is a story in the form of a collection of personal perspectives from our medical team members who treated a young woman with osteosarcoma and worked together to realize her final wish. She not only made an [...]MDPI: Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion (Houghton)
September 28, 2021
Roxane R. Lavoie Patricio C. Gargollo Mohamed E. Ahmed Yohan Kim Emily Baer Doris A. Phelps Cristine M. Charlesworth Benjamin J. Madden Liguo Wang Peter J. Houghton John Cheville Haidong Dong Candace F. Granberg Fabrice Lucien Simple Summary Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children, and there is a critical need to […]
Journal of Virology: MULTIPLEXED SIV-SPECIFIC PAIRED RNA-GUIDED CAS9 NICKASES INACTIVATE PROVIRAL DNA (Lai)
September 23, 2021
Authors: Lisa M Smith, Jason T. Ladner, Vida L. Hodara, Laura M. Parodi, R. Alan Harris, Jessica E. Callery, Zhao Lai, Yi Zou, Muthuswamy Raveedran, Jeffrey Rogers, and Luis D. Giavedoni Abstract Human and simian immunodeficiency virus infections establish a lifelong reservoir of cells harboring an integrated proviral genome. Genome editing CRISPR-associated Cas9 nucleases, combined […]
Cambridge Core: Examining Access to Care in Clinical Genomic Research and Medicine: Experiences from the CSER Consortium (Tomlinson)
September 21, 2021
Amanda M. Gutierrez[Opens in a new windo Jill O. Robinson, Simon M. Outram, Hadley S. Smith, Stephanie A. Kraft, Katherine E. Donohue, Barbara B. Biesecker, Kyle B. Brothers, Flavia Chen, Benyam Hailu, Lucia A. Hindorff, Hannah Hoban, Rebecca L. Hsu, Sara J. Knight, Barbara A. Koenig, Katie L. Lewis, Kristen Hassmiller Lich, Julianne M. O’Daniel, […]
MDPI: Design and Characterization of a Cell-Penetrating Peptide Derived from the SOX2 Transcription Factor (Blancafort)
September 10, 2021
Neha S. Gandhi Edina Wang Anabel Sorolla Yu Jie Kan Adil Malik Jyotsna Batra Kimberly A. Young Wan Jun Tie Pilar Blancafort Ricardo L. Mancera Abstract SOX2 is an oncogenic transcription factor overexpressed in nearly half of the basal-like triple-negative breast cancers associated with very poor outcomes. Targeting and inhibiting SOX2 is clinically relevant as […]