Research Paper
Frontiers in Psychiatry: The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers
September 23, 2013
Jason D Robinson 1, Francesco Versace, Cho Y Lam, Jennifer A Minnix, Jeffrey M Engelmann, Yong Cui, Maher Karam-Hage, Sanjay S Shete, Gail E Tomlinson, Tina T-L Chen, David W Wetter, Charles E Green, Paul M Cinciripini Abstract A compromised brain reward system has been postulated as a key feature of drug dependence. We examined whether several polymorphisms of genes found to regulate nicotinic acetylcholine receptor (nAChR) and […]
Echocardiography: Cardiac Assessment in Pediatric Mice: Strain Analysis as a Diagnostic Measurement
September 19, 2013
Thomas G. Andrews M.Sc., Merry L. Lindsey PhD, Richard A. Lange MD, M.B.A, Gregory J. Aune MD, PhD Abstract Echocardiography is a robust tool for assessing cardiac function in both humans and laboratory animals. Conventional echocardiographic measurements, including chamber dimensions, wall thickness, and ejection fraction are routinely obtained to assess cardiac function in mice. Recently, […]
Oncogene:miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer
September 16, 2013
L Du, Z Zhao, X Ma, T-H Hsiao, Y Chen, E Young, M Suraokar, I Wistuba, J D Minna & A Pertsemlidis Abstract The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully […]
Modern Pathology: Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium
September 6, 2013
Dolores López-Terrada 1, Rita Alaggio 2, Maria T de Dávila 3, Piotr Czauderna 4, Eiso Hiyama 5, Howard Katzenstein 6, Ivo Leuschner 7, Marcio Malogolowkin 8, Rebecka Meyers 9, Sarangarajan Ranganathan 10, Yukichi Tanaka 11, Gail Tomlinson 12, Monique Fabrè 13, Arthur Zimmermann 14, Milton J Finegold 1, Children’s Oncology Group Liver Tumor Committee Abstract Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors […]
Oncogene: Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer
August 26, 2013
S S Roy 1, V K Gonugunta 1, A Bandyopadhyay 2, M K Rao 3, G J Goodall 4, L-Z Sun 3, R R Tekmal 5, R K Vadlamudi 5 Abstract Tumor metastasis is the leading cause of death among breast cancer patients. PELP1 (proline, glutamic acid, and leucine-rich protein 1) is a nuclear receptor coregulator that is upregulated during breast cancer progression to metastasis and is an independent prognostic […]
Cancer Cell: Amplification of Distant Estrogen Response Elements Deregulates Target Genes Associated with Tamoxifen Resistance in Breast Cancer
August 12, 2013
Pei-YinHsu1 Hang-KaiHsu1 XunLan6 LiranJuan9 Pearlly S.Yan7 JadwigaLabanowska8 NylaHeerema8 Tzu-HungHsiao4 Yu-ChiaoChiu5 YidongChen34 YunlongLiu9 LangLi9RongLi1I an M.Thompson2 Kenneth P.Nephew10 Zelton D.Sharp 1 Nameer B.Kirma1 Victor X.Jin6 Tim H.-M.Huang1 Summary A causal role of gene amplification in tumorigenesis is well known, whereas amplification of DNA regulatory elements as an oncogenic driver remains unclear. In this study, we integrated next-generation sequencing approaches to map distant estrogen response elements (DEREs) that […]
Experimental Hematology: Myelodysplastic syndrome: An inability to appropriately respond to damaged DNA?
August 1, 2013
Author links open overlay panelTingZhouab PaulHastycde Christi A.Walterbdef Alexander J.R.Bishopabde Linda M.Scottg Vivienne I.Rebelabde Myelodysplastic syndrome (MDS) is considered a hematopoietic stem cell disease that is characterized by abnormal hematopoietic differentiation and a high propensity to develop acute myeloid leukemia. It is mostly associated with advanced age, but also with prior cancer therapy and inherited […]
Pediatric Blood & Cancer: Outcomes for patients with congenital hepatoblastoma
June 24, 2013
Angela D Trobaugh-Lotrario 1, Barbara H Chaiyachati, Rebecka L Meyers, Beate Häberle, Gail E Tomlinson, Howard M Katzenstein, Marcio H Malogolowkin, Dietrich von Schweinitz, Mark Krailo, James H Feusner Abstract Background: Congenital hepatoblastoma, diagnosed in the first month of life, has been reported to have a poor prognosis; however, a comprehensive evaluation of this entity is lacking. Procedure: We retrospectively reviewed two patients from the senior authors’ […]
Bioinformatics: Exome-based analysis for RNA epigenome sequencing data
June 15, 2013
Jia Meng, Xiaodong Cui, Manjeet K. Rao, Yidong Chen, Yufei Huang Abstract Motivation: Fragmented RNA immunoprecipitation combined with RNA sequencing enabled the unbiased study of RNA epigenome at a near single-base resolution; however, unique features of this new type of data call for novel computational techniques. Result: Through examining the connections of RNA epigenome sequencing data with two well-studied data […]
Echocardiography: Cardiac Assessment in Pediatric Mice: Strain Analysis as a Diagnostic Measurement
June 7, 2013
Thomas G. Andrews, M.Sc.,* Merry L. Lindsey, PhD,† Richard A. Lange, MD, M.B.A,‡ and Gregory J. Aune, MD, PhD§ Echocardiography is a robust tool for assessing cardiac function in both humans and laboratory animals. Conventional echocardiographic measurements, including chamber dimensions, wall thickness, and ejection fraction are routinely obtained to assess cardiac function in mice. Recently, […]