Journal of Community Support Oncology: Reaching high-risk underserved individuals for cancer genetic counseling by video-teleconferencing

April 1, 2016

Lindsey A Mette 1 2, Anna Maria Pulido Saldívar 2 3, Natalie E Poullard 1 2, Ivette C Torres 2 4, Sarah G Seth 1 2, Brad H Pollock 5 6, Gail E Tomlinson 7 2 6 Abstract Background: Breast and colorectal cancers are common cancers for which genetic risk assessment and counseling are available. However, these services are often limited to metropolitan areas and are not readily accessible to underserved populations. Moreover, ethnic and racial disparities […]

Experimental Biology and Medicine: Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease

March 27, 2016

 Li Liu, Alexander Pertsemlidis, Liang-Hao Ding, Michael D Story, Martin H Steinberg, Paola Sebastiani, Carolyn Hoppe, Samir K Ballas, Betty S Pace Abstract Sickle cell disease (SCD) is a group of inherited blood disorders that have in common a mutation in the sixth codon of the β-globin (HBB) gene on chromosome 11. However, people with the same genetic mutation display a wide range [...]

Pediatric Blood & Cancer: Initial Testing of NSC 750854, a Novel Purine Analog, Against Pediatric Tumor Models by the Pediatric Preclinical Testing Program

March 1, 2016

Richard Gorlick 1, E Anders Kolb 2, Stephen T Keir 3, John M Maris 4, Richard B Lock 5, Hernan Carol 5, C Patrick Reynolds 6, Min H Kang 6, Catherine A Billups 7, Jerry Collins 8, Dias Kurmashev 9, Raushan T Kurmasheva 9, Peter J Houghton 9, Malcolm A Smith 10 Abstract Background: NSC 750854 is a purine analog with an antitumor activity profile distinctive from that of other anticancer purines. It has shown significant activity against adult cancer preclinical models. Procedure: NSC […]

Scientific Report: Roles of Distal and Genic Methylation in the Development of Prostate Tumorigenesis Revealed by Genome-wide DNA Methylation Analysis

February 29, 2016

Yao Wang 1, Rohit Ramakant Jadhav 1, Joseph Liu 1, Desiree Wilson 2, Yidong Chen 3, Ian M Thompson 4 5, Dean A Troyer 6, Javier Hernandez 4, Huidong Shi 7, Robin J Leach 2 4 5, Tim H-M Huang 1 5, Victor X Jin 1 3 Abstract Aberrant DNA methylation at promoters is often linked to tumorigenesis. But many aspects of DNA methylation remain unexplored, including the individual roles of distal and gene body methylation, as well as their collaborative roles with […]

Pediatric Blood & Cancer: Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program

February 1, 2016

Edward F Attiyeh, John M Maris 1, Richard Lock 2, C Patrick Reynolds 3, Min H Kang 3, Hernan Carol 2, Richard Gorlick 4, E Anders Kolb 5, Stephen T Keir 6, Jianrong Wu 7, Yosef Landesman 8, Sharon Shacham 8, Dmitry Lyalin 9, Raushan T Kurmasheva 9, Peter J Houghton 9, Malcolm A Smith 10 Abstract Background: Selinexor (KPT-330) is an inhibitor of the major nuclear export receptor, exportin 1 (XPO1, also termed chromosome region maintenance 1, CRM1) that has demonstrated activity in preclinical models […]

IEEE: Cancer Progression Prediction Using Gene Interaction Regularized Elastic Net.

December 23, 2015

Lin Zhang; Hui Liu; Yufei Huang; Xuesong Wang; Yidong Chen; Jia Meng Abstract: Different types of genomic aberration may simultaneously contribute to tumorigenesis. To obtain a more accurate prognostic assessment to guide therapeutic regimen choice for cancer patients, the heterogeneous multi-omics data should be integrated harmoniously, which can often be difficult. For this purpose, we propose a Gene Interaction Regularized […]

Molecular Cancer Research: Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor

December 1, 2015

Amelie Forest 1, Michael Amatulli 1, Dale L Ludwig 1, Christopher B Damoci 1, Ying Wang 1, Colleen A Burns 1, Gregory P Donoho 2, Nina Zanella 3, Heinz H Fiebig 3, Marie C Prewett 1, David Surguladze 1, James T DeLigio 1, Peter J Houghton 4, Malcolm A Smith 5, Ruslan Novosiadly 6 Abstract Despite a recent shift away from anti-insulin-like growth factor I receptor (IGF-IR) therapy, this target has been identified as a key player in the resistance mechanisms to various conventional […]

Genes & Cancer: The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma

November 7, 2015

David J. Elzi1, Meihua Song1, Peter J. Houghton1,2,3, Yidong Chen1,2,4, and Yuzuru Shiio1,2,5 ABSTRACT Ewing sarcoma is a cancer of the bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family transcription factor, most commonly FLI-1. The EWS-FLI-1 fusion oncogene is widely believed to play a central […]

Business Wire: Epizyme to Present New Scientific Data on the Role of HMT Inhibitors in Cancer

November 4, 2015

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Epizyme, Inc. (NASDAQ: EPZM), a clinical-stage biopharmaceutical company creating novel epigenetic therapies for cancer patients, will present data from 11 accepted abstracts on the role of histone methyltransferase (HMT) inhibition in human cancers at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics taking place in Boston, Mass., November 5 – 9, […]