Category
October 1, 2012
Maria Luisa C, Policarpio-NicolasMDa, Philip T.ValenteMDa , Gregory J.Aune MD, PhDb , Russell A.HigginsMDa Abstract Involvement of the female genital tract by myeloid sarcoma as the initial presentation is extremely uncommon, especially in the vagina. The lack of specific histologic features and the unusual location can be a diagnostic challenge to both the surgical pathologist and the […]
September 25, 2012
Research at the UT Health Science Center Greehey Children’s Cancer Research Institute is vital for families with children who have cancer, and is getting a financial boost through a Hyundai Hope Grant.
September 21, 2012
Hima Bansal 1, Theresea Seifert, Carlos Bachier, Manjeet Rao, Gail Tomlinson, Swaminathan Padmanabhan Iyer, Sanjay Bansal Abstract Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is considered a promising cancer therapeutic agent due to its ability to induce apoptosis in a variety of cancer cells while sparing normal cells. However, many human tumors including acute myeloid leukemia (AML) are partially or completely resistant […]
September 7, 2012
Aaron Sugalski 1, Mary Davis, Latha Prasannan, Victor Saldivar, Jaclyn Y Hung, Gail E Tomlinson Abstract Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was […]
August 1, 2012
Young-Ho Ahn,1 Don L. Gibbons,1,2 Deepavali Chakravarti,3 Chad J. Creighton,4 Zain H. Rizvi,1 Henry P. Adams,5 Alexander Pertsemlidis,6 Philip A. Gregory,7,8 Josephine A. Wright,7,8 Gregory J. Goodall,7,8,9 Elsa R. Flores,3 and Jonathan M. Kurie1 Abstract Metastatic cancer is extremely difficult to treat, and the presence of metastases greatly reduces a cancer patient’s likelihood of long-term survival. The ZEB1 transcriptional repressor promotes metastasis through downregulation of microRNAs (miRs) […]
August 1, 2012
Yuan C Ding 1, Lesley McGuffog, Sue Healey, Eitan Friedman, Yael Laitman, Shani- Paluch-Shimon, Bella Kaufman, SWE-BRCA; Annelie Liljegren, Annika Lindblom, Håkan Olsson, Ulf Kristoffersson, Marie Stenmark-Askmalm, Beatrice Melin, Susan M Domchek, Katherine L Nathanson, Timothy R Rebbeck, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna Durda, Jacek Gronwald, Tomasz Huzarski, Cezary Cybulski, Tomasz Byrski, Ana Osorio, Teresa Ramóny Cajal, Alexandra V Stavropoulou, Javier Benítez, Ute Hamann, HEBON; Matti Rookus, Cora M Aalfs, Judith L de Lange, Hanne E J Meijers-Heijboer, Jan C Oosterwijk, Christi J van Asperen, Encarna B Gómez García, Nicoline Hoogerbrugge, Agnes Jager, Rob [...]July 23, 2012
Abstract Exposure to DNA-damaging agents invokes biological responses necessary for damage recovery and cell survival. Despite the presence of intact DNA repair pathways, a lack of certain other biological pathways has been shown to sensitize cells to DNA-damaging agents’ exposure. It is likely that following DNA damage a complex interplay between DNA repair pathways and […]
July 20, 2012
Subbarayalu Panneerdoss, Yao-Fu Chang, Kalyan C. Buddavarapu, Hung-I Harry Chen, Gunapala Shetty, Huizhen Wang, Yidong Chen, T. Rajendra Kumar, Manjeet K. Rao Abstract Although decades of research have established that androgen is essential for spermatogenesis, androgen’s mechanism of action remains elusive. This is in part because only a few androgen-responsive genes have been definitively identified in the testis. Here, we propose that […]
July 13, 2012
Gail E Tomlinson 1, Roland Kappler Abstract A number of unique genetic features are observed in hepatoblastoma that has provided insights into the origins of hepatoblastoma. Hallmark cytogenetic changes in hepatoblastoma include the acquisition of additional copies of whole chromosomes and a recurring unbalanced translocation involving 1q. Genetic syndromes are associated with approximately 15% of hepatoblastoma and […]
July 13, 2012
Fang-Han Hsu; Erchin Serpedin; Yidong Chen; Edward R. Dougherty Abstract: DNA copy number alterations (CNAs) are known to be related to genetic diseases, including cancer. The unlimited transcription (UT) model, in which transcription occurs permissively with a simple activation probability, has been proposed to investigate the long-term effects of CNAs on gene expression values. The queueing theory was […]