Cancer Research: RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers

January 1, 2008

Boning Gao 1, Xian-Jin Xie, Chunxian Huang, David S Shames, Tina T-L Chen, Cheryl M Lewis, Aihua Bian, Bifeng Zhang, Olufunmilayo I Olopade, Judy E Garber, David M Euhus, Gail E Tomlinson, John D Minna Abstract The tumor suppressor gene RASSF1A regulates cell cycle progression, apoptosis, and microtubule stability and is inactivated by promoter methylation in approximately 50% of breast cancers. It has been shown previously that the […]

Clinical Breast Cancer: Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a prospective cohort of unaffected BRCA1 and BRCA2 mutation carriers

December 1, 2007

Tara M Friebel 1, Susan M Domchek, Susan L Neuhausen, Theresa Wagner, D Gareth Evans, Claudine Isaacs, Judy E Garber, Mary B Daly, Rosalind Eeles, Ellen Matloff, Gail Tomlinson, Henry T Lynch, Nadine Tung, Joanne L Blum, Jeffrey Weitzel, Wendy S Rubinstein, Patricia A Ganz, Fergus Couch, Timothy R Rebbeck Abstract Background: Women with BRCA1 or BRCA2 (BRCA1/2) mutations can reduce cancer incidence and mortality by using bilateral prophylactic oophorectomy (BPO) or bilateral prophylactic mastectomy […]

Molecular Cancer Research: Mouse Embryo Fibroblasts Lacking the Tumor Suppressor Menin Show Altered Expression of Extracellular Matrix Protein Genes

October 1, 2007

Abstract Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized primarily by endocrine tumors of the parathyroids, anterior pituitary, and enteropancreatic endocrine tissues. Affected individuals carry a germ-line loss-of-function mutation of the MEN1 gene, and tumors arise after the loss of the second allele. Homozygous loss of Men1 in the germline of […]

Cancer Biology & Therapy: Silencing of lactotransferrin expression by methylation in prostate cancer progression

July 11, 2007

Syed Shaheduzzaman, Anu Vishwanath, Bungo Furusato, Jennifer Cullen, Yongmei Chen, Lionel Bañez, Martin Nau, Lakshmi Ravindranath, Kee-Hong Kim, Ahmed Mohammed, Yidong Chen, Mathias Ehrich, Vasantha Srikantan, Isabell A. Sesterhenn, David G. McLeod, Maryanne Vahey,Gyorgy Petrovics,Albert Dobi &Shiv Srivastava Abstract Background: Cancer cells gain selection advantages by the coordinated silencing of protective and by the activation of […]

Advances in Genetics: Involvement of Homologous Recombination in Carcinogenesis

April 21, 2007

Author links open overlay panelRamuneReliene* Alexander J.R.Bishop §Robert H.Schiestl*†‡ Abstract DNA alterations of every type are associated with the incidence of carcinogenesis, often on the genomic scale. Although homologous recombination (HR) is an important pathway of DNA repair, the evidence is accumulating that deleterious genomic rearrangements can result from HR. It, therefore, follows that HR events may play […]

Clinical Cancer Research: Gene Expression Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma

February 1, 2007

Hu-Liang Jia, Qing-Hai Ye, Lun-Xiu Qin, Anuradha Budhu, Marshonna Forgues, Yidong Chen, Yin-Kun Liu, Hui-Chuan Sun, Lu Wang, Hong-Zhou Lu, Fang Shen, Zhao-You Tang and Xin Wei Wang Abstract Purpose: Hepatocellular carcinoma (HCC), common cancer worldwide, has a dismal outcome partly due to the poor identification of early-stage HCC. Currently, one-third of HCC patients present with low serum α-fetoprotein (AFP) levels, the only clinically available diagnostic marker for HCC. The aim of this study was to identify new diagnostic molecular markers […]

Technology in Cancer Research & Treatment: Wnt-1 is Dominant over Neu in Specifying Mammary Tumor Expression Profiles

December 1, 2006

Shixia Huang, PhD*, Katrina Podsypanina, PhD, Yidong Chen, PhD,  Weiyan Cai, Anna Tsimelzon, PhD, Susan Hilsenbeck, PhD, Yi Li, PhD Abstract Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both MMTV-Wnt-1 and MMTV-Neu. In this report, gene expression profiles were determined for tumors from these bitransgenic mice and compared with expression profiles of tumors from mice singly transgenic for MMTV-Wnt-1 or MMTV-Neu. While very different from tumors arising […]

Nature Methods: Sensitive and specific method for detecting G protein–coupled receptor mRNAs

November 19, 2006

Arne Hansen, Yidong Chen, Jason M Inman, Quang N Phan, Zhi-Qing Qi, Charlie C Xiang, Miklos Palkovits, Natasha Cherman, Sergei A Kuznetsov, Pamela G Robey, Eva Mezey & Michael J Brownstein Abstract G protein-coupled receptors (GPCRs) mediate the effects of extracellular signaling molecules in all the body’s cells. These receptors are encoded by scarce mRNAs; therefore, detecting their transcripts with conventional microarrays is difficult. We present a […]

The American Journal of Pathology: A Novel Role of Myosin VI in Human Prostate Cancer

November 1, 2006

Thomas A.Dunn*, Shenglin Chen*, Dennis A.Faith†, Jessica L.Hicks† Elizabeth A.Platz*‡,  Yidong  Chen§, Charles M.Ewing*, Jurga Sauvageot*, William B.Isaacs*†, Angelo M.De Marzo*†, Jun, Luo* Myosin VI is an actin motor that moves to the minus end of the polarized actin filament, a direction opposite to all other characterized myosins. Using expression microarrays, we identified myosin VI as one of the top […]