Research Paper

Fertility and Sterility: Identification of molecular markers for endometriosis in blood lymphocytes by using deoxyribonucleic acid microarrays

June 1, 2006

Idhaliz FloresPhDa  Elizabeth RiveraM.Ed.a  Spyro MoussesPhDb  Yidong ChenPhDc  Ester RozenblumPhDd   Objective To identify molecular biomarkers for endometriosis in peripheral blood lymphocytes by using DNA microarrays. Design Case-control. Setting Multicenter academic research programs. Patient(s) Premenopausal women with or without endometriosis, determined by obstetrics and gynecology specialists during surgery. Microarray analysis included six endometriosis patients and five controls; 15 endometriosis patients and 15 controls were analyzed […]


Molecular Human Reproduction: Gene expression profiling of human placentas from preeclamptic and normotensive pregnancies

March 23, 2006

S.R. Hansson, Y. Chen, J. Brodszki, M. Chen, E. Hernandez-Andrade, J.M. Inman, O.A. Kozhich, I. Larsson, K. Marsál, P. Medstrand, C.C. Xiang, M.J. Brownstein Abstract The aim of this study was to investigate patterns of gene expression in placental samples from patients with preeclampsia (PE), persistent bilateral uterine artery notching (without PE), and normal controls. This study included placental tissue from nine women with PE, […]


Oncogene: Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells

November 13, 2005

M-H Tsai, X Chen, G V R Chandramouli, Y Chen, H Yan, S Zhao, P Keng, H L Liber, C N Coleman, J B Mitchell & E Y Chuang Abstract The p53 protein has been implicated in multiple cellular responses related to DNA damage. Alterations in any of these cellular responses could be related to increased genomic instability. Our previous study has shown that mutations in […]


DNA Repair: p21 controls patterning but not homologous recombination in RPE development

August 15, 2005

Author links open overlay panelA.J.R.Bishopa  B.Kosarasb M.C.Hollanderc A.FornaceJr.c R.L.Sidmanb R.H.Schiestld Abstract p21/WAF1/CIP1/MDA6 is a key cell cycle regulator. Cell cycle regulation is an important part of development, differentiation, DNA repair, and apoptosis. Following DNA damage, p53 dependent expression of p21 results in a rapid cell cycle arrest. p21 also appears to be important for the […]