Greehey Children's Cancer Research Institute
Category
July 21, 2010
Alison Claybon, Bijal Karia, Crystal Bruce, Alexander J. R. Bishop Abstract Recent studies suggest that PARP1 inhibitors, several of which are currently in a clinical trial, may selectively kill BRCA1/2 mutant cancer cells. It is thought that the success of this therapy is based on immitigable lethal DNA damage in the cancer cells resultant from the concurrent loss […]
July 5, 2010
J S Imam, K Buddavarapu, J S Lee-Chang, S Ganapathy, C Camosy, Y Chen & M K Rao Abstract Homeobox genes encode transcription factors that are essential for normal development and are often dysregulated in cancers. The molecular mechanisms that cause their misregulation in cancers are largely unknown. In this study, we investigate the mechanism by which the Six1 homeobox protein, which […]
June 17, 2010
Liqin Du, Jeoffrey J Schageman, Irnov, Luc Girard, Scott M Hammond, John D Minna, Adi F Gazdar & Alexander Pertsemlidis Abstract Background Recent studies have shown that microRNAs (miRNAs) play roles in tumorigenesis and are reliable classifiers of certain cancer types and subtypes. However, the role of miRNAs in the pathogenesis and diagnosis of small cell […]
March 30, 2010
Amy M Wiles, Mark Doderer, Jianhua Ruan, Ting-Ting Gu, Dashnamoorthy Ravi, Barron Blackman & Alexander JR Bishop Abstract Background A genomic catalog of protein-protein interactions is a rich source of information, particularly for exploring the relationships between proteins. Numerous systems-wide and small-scale experiments have been conducted to identify interactions; however, our knowledge of all interactions for any one species is incomplete, and […]
February 24, 2010
Susan M Domchek 1, Tara M Friebel, Judy E Garber, Claudine Isaacs, Ellen Matloff, Rosalind Eeles, D Gareth Evans, Wendy Rubinstein, Christian F Singer, Stephen Rubin, Henry T Lynch, Mary B Daly, Jeffrey Weitzel, Patricia A Ganz, Gabriella Pichert, Olufunmilayo I Olopade, Gail Tomlinson, Nadine Tung, Joanne L Blum, Fergus Couch, Timothy R Rebbeck Abstract Risk-reducing salpingo-oophorectomy (RRSO) is widely used for cancer risk reduction in BRCA1 or BRCA2 (BRCA1/2) mutation carriers. Occult ovarian/fallopian tube cancers […]
December 1, 2009
Tina T-L Chen 1, Dinesh Rakheja, Jaclyn Y Hung, Peter J Hornsby, Piotr Tabaczewski, Marcio Malogolowkin, James Feusner, Frank Miskevich, Roger Schultz, Gail E Tomlinson Abstract Background: Hepatoblastoma is a rare malignancy of childhood. The scarcity of adequate cell models has limited our understanding of this tumor. Here we describe and characterize a new human liver tumor cell line, Hep293TT, derived from an aggressive childhood hepatoblastoma. […]
November 18, 2009
Amanda B Spurdle 1, Paul Fahey, Xiaoqing Chen, Lesley McGuffog, kConFab; Douglas Easton, Susan Peock, Margaret Cook, EMBRACE; Jacques Simard, INHERIT; Tim R Rebbeck, MAGIC; Antonis C Antoniou, Georgia Chenevix-Trench Abstract The GSTP1, GSTM1, and GSTT1 detoxification genes all have functional polymorphisms that are common in the general population. A single study of 320 BRCA1/2 carriers previously assessed their effect in BRCA1 or BRCA2 mutation carriers. This study showed no […]
October 20, 2009
Susan L Neuhausen 1, Sean Brummel, Yuan Chun Ding, Christian F Singer, Georg Pfeiler, Henry T Lynch, Katherine L Nathanson, Timothy R Rebbeck, Judy E Garber, Fergus Couch, Jeffrey Weitzel, Steven A Narod, Patricia A Ganz, Mary B Daly, Andrew K Godwin, Claudine Isaacs, Olufunmilayo I Olopade, Gail Tomlinson, Wendy S Rubinstein, Nadine Tung, Joanne L Blum, Daniel L Gillen Abstract Introduction: Women who carry mutations in BRCA1 and BRCA2 have a substantially increased risk of developing breast […]
October 19, 2009
Dashnamoorthy Ravi, Amy M. Wiles, Selvaraj Bhavani, Jianhua Ruan, Philip Leder, Alexander J. R. Bishop Abstract Damage initiates a pleiotropic cellular response aimed at cellular survival when appropriate. To identify genes required for damage survival, we used a cell-based RNAi screen against the Drosophila genome and the alkylating agent methyl methanesulphonate (MMS). Similar studies performed in other model organisms report […]
October 8, 2009
Junfang Ji, PhD, Jiong Shi, MD, Anuradha Budhu, PhD, Zhipeng Yu, B.S., Marshonna Forgues, B.S., Stephanie Roessler, PhD, Stefan Ambs, PhD, M.P.H., Yidong Chen, PhD, Paul S. Meltzer, MD, Carlo M. Croce, MD, Lun-Xiu Qin, MD, PhD, Kwan Man, MD, PhD, Abstract BACKGROUND Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, and response to interferon […]