Research Paper

Oncogene: Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells

November 13, 2005

M-H Tsai, X Chen, G V R Chandramouli, Y Chen, H Yan, S Zhao, P Keng, H L Liber, C N Coleman, J B Mitchell & E Y Chuang Abstract The p53 protein has been implicated in multiple cellular responses related to DNA damage. Alterations in any of these cellular responses could be related to increased genomic instability. Our previous study has shown that mutations in […]

DNA Repair: p21 controls patterning but not homologous recombination in RPE development

August 15, 2005

Author links open overlay panelA.J.R.Bishopa B.Kosarasb M.C.Hollanderc A.FornaceJr.c R.L.Sidmanb R.H.Schiestld Abstract p21/WAF1/CIP1/MDA6 is a key cell cycle regulator. Cell cycle regulation is an important part of development, differentiation, DNA repair, and apoptosis. Following DNA damage, p53 dependent expression of p21 results in a rapid cell cycle arrest. p21 also appears to be important for the […]