Community Genetics: Successful strategies for increasing African American participation in cancer genetic studies: hopeful signs for equalizing the benefits of genetic medicine

April 14, 2008

Annette R Patterson 1, Helen Davis, Kristin Shelby, Jerry McCoy, Linda D Robinson, Smita K Rao, Pia Banerji, Gail E Tomlinson Abstract Objective: To determine whether prior success in recruiting African Americans to an in-house cancer genetics registry could be duplicated when recruiting to a national registry requiring a significantly increased level of commitment. Additionally, to determine which recruitment sources and practices yielded the […]

American Journal of Human Genetics: Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

April 1, 2008

Antonis C Antoniou 1, Amanda B Spurdle, Olga M Sinilnikova, Sue Healey, Karen A Pooley, Rita K Schmutzler, Beatrix Versmold, Christoph Engel, Alfons Meindl, Norbert Arnold, Wera Hofmann, Christian Sutter, Dieter Niederacher, Helmut Deissler, Trinidad Caldes, Kati Kämpjärvi, Heli Nevanlinna, Jacques Simard, Jonathan Beesley, Xiaoqing Chen, Kathleen Cuningham Consortium for Research into Familial Breast Cancer; Susan L Neuhausen, Timothy R Rebbeck, Theresa Wagner, Henry T Lynch, Claudine Isaacs, Jeffrey Weitzel, Patricia A Ganz, Mary B Daly, Gail Tomlinson, Olufunmilayo I Olopade, Joanne L Blum, Fergus J Couch, Paolo Peterlongo, Siranoush […]

Cancer Research: Chromosomal Breakpoints in Primary Colon Cancer Cluster at Sites of Structural Variants in the Genome

March 1, 2008

Jordi Camps, Marian Grade, Quang Tri Nguyen, Patrick Hörmann, Sandra Becker, Amanda B. Hummon, Virginia Rodriguez, Settara Chandrasekharappa, Yidong Chen, Michael J. Difilippantonio, Heinz Becker, B. Michael Ghadimi and Thomas Ried Abstract Genomic aberrations on chromosome 8 are common in colon cancer and are associated with lymph node and distant metastases as well as with disease susceptibility. This prompted us to generate a high-resolution map of genomic imbalances of chromosome 8 in 51 primary colon carcinomas using a custom-designed genomic array […]

Cancer Research: EpCAM and α-Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma

March 1, 2008

Taro Yamashita, Marshonna Forgues, Wei Wang, Jin Woo Kim, Qinghai Ye, Huliang Jia, Anuradha Budhu, Krista A. Zanetti, Yidong Chen, Lun-Xiu Qin, Zhao-You Tang, and Xin Wei Wang Abstract The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Recently, we have identified that a hepatic stem cell marker, epithelial cell adhesion molecule (EpCAM), may serve as an early biomarker of HCC because its expression is highly elevated in […]

Pediatric Blood & Cancer: Treatment of Wilms tumor relapsing after initial treatment with vincristine, actinomycin D, and doxorubicin. A report from the National Wilms Tumor Study Group

February 1, 2008

Marcio Malogolowkin 1, Cecilia A Cotton, Daniel M Green, Norman E Breslow, Elizabeth Perlman, James Miser, Michael L Ritchey, Patrick R M Thomas, Paul E Grundy, Giulio J D’Angio, J Bruce Beckwith, Robert C Shamberger, Gerald M Haase, Milton Donaldson, Robert Weetman, Max J Coppes, Patricia Shearer, Peter Coccia, Morris Kletzel, Roger Macklis, Gail Tomlinson, Vicki Huff, Robert Newbury, Douglas Weeks, National Wilms Tumor Study Group Abstract Objective: We evaluated the use of alternating cycles of cyclophosphamide/etoposide and carboplatin/etoposide in children […]

Neoplasia: Comparison of Expression Profiles of Metastatic versus Primary Mammary Tumors in MMTV-Wnt-1 and MMTV-Neu Transgenic Mice1

February 1, 2008

Author links open overlay panelShixia Huang*†‡, Yidong Chen§, Katrina Podsypanina Abstract Distant metastases of human breast cancers have been suggested to be more different from each other than from their respective primary tumors, based on expression profiling. The mechanism behind this lack of similarity between individual metastases is not known. We used cDNA microarrays to […]

Cancer Research: RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers

January 1, 2008

Boning Gao 1, Xian-Jin Xie, Chunxian Huang, David S Shames, Tina T-L Chen, Cheryl M Lewis, Aihua Bian, Bifeng Zhang, Olufunmilayo I Olopade, Judy E Garber, David M Euhus, Gail E Tomlinson, John D Minna Abstract The tumor suppressor gene RASSF1A regulates cell cycle progression, apoptosis, and microtubule stability and is inactivated by promoter methylation in approximately 50% of breast cancers. It has been shown previously that the […]

Clinical Breast Cancer: Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a prospective cohort of unaffected BRCA1 and BRCA2 mutation carriers

December 1, 2007

Tara M Friebel 1, Susan M Domchek, Susan L Neuhausen, Theresa Wagner, D Gareth Evans, Claudine Isaacs, Judy E Garber, Mary B Daly, Rosalind Eeles, Ellen Matloff, Gail Tomlinson, Henry T Lynch, Nadine Tung, Joanne L Blum, Jeffrey Weitzel, Wendy S Rubinstein, Patricia A Ganz, Fergus Couch, Timothy R Rebbeck Abstract Background: Women with BRCA1 or BRCA2 (BRCA1/2) mutations can reduce cancer incidence and mortality by using bilateral prophylactic oophorectomy (BPO) or bilateral prophylactic mastectomy […]

Molecular Cancer Research: Mouse Embryo Fibroblasts Lacking the Tumor Suppressor Menin Show Altered Expression of Extracellular Matrix Protein Genes

October 1, 2007

Abstract Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized primarily by endocrine tumors of the parathyroids, anterior pituitary, and enteropancreatic endocrine tissues. Affected individuals carry a germ-line loss-of-function mutation of the MEN1 gene, and tumors arise after the loss of the second allele. Homozygous loss of Men1 in the germline of […]