A role for Notch in self-renewal in Embryonal Rhabdomyosarcoma

Funding Agency: K99/R00 National Institutes of Health (NCI)

Title: A role for Notch in self-renewal in Embryonal Rhabdomyosarcoma.

Status: Active

Period: 2014-2019

Role: Principal Investigator

Grant Detail: The major goal of this project is to determine the effects of misregulation of Notch signaling pathway on relapse or tumor propagating cell self-renewal in Embryonal Rhabdomyosarcoma. Building on earlier experiments, this proposal will identify Notch regulated targets that drive tumor relapse and differentiation. Understanding Notch signaling effects in this pediatric solid tumor can potentially lead to new avenues of treatment.

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on childhood cancer by discovering, developing, and disseminating new scientific knowledge. Our mission consists of three key areas — research, clinical, and education.

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