Funding Agency: K99/R00 National Institutes of Health (NCI)
Title: A role for Notch in self-renewal in Embryonal Rhabdomyosarcoma.
Status: Active
Period: 2014-2019
Role: Principal Investigator
Grant Detail: The major goal of this project is to determine the effects of misregulation of Notch signaling pathway on relapse or tumor propagating cell self-renewal in Embryonal Rhabdomyosarcoma. Building on earlier experiments, this proposal will identify Notch regulated targets that drive tumor relapse and differentiation. Understanding Notch signaling effects in this pediatric solid tumor can potentially lead to new avenues of treatment.