Angelina Vaseva, PhD Presented 2021 Voelcker Pilot Award (Houghton Lab)
Dr. Vaseva’s project is “ Vertical Inhibition of the RAF-MEK-ERK Pathway in RAS-driven Rhabdomyosarcoma”. Her studies are centered on the development of novel targeted therapeutic strategies for pediatric cancers driven by RAS oncogenic mutations. The funds provided by the Voelcker Foundation will be used to better understand the mode of action of vertical inhibition of the MAPK pathway in RAS-driven Rhabdomyosarcoma and identify biomarkers of response to this approach.
The goal is to facilitate the improved design of clinical trials. Toward these aims, Dr. Vaseva’s laboratory will employ a wide variety of in vitro and in vivo drug response assays, patient-derived xenograft models, and omics approaches.
Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on childhood cancer by discovering, developing, and disseminating new scientific knowledge. Our mission consists of three key areas — research, clinical, and education.
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