Dr. Raushan Kurmasheva Received the CURE Childhood Cancer Award
Abstract
Atypical teratoid/rhabdoid tumors (AT/RT) of the brain and malignant rhabdoid tumors of the kidney (RTK) compose a group of highly malignant pediatric cancers known as malignant rhabdoid tumors (MRT). Both subtypes are characterized by the biallelic loss of the SMARCB1 gene (member of the human SWI/SNF complex), which is thought to function as a tumor suppressor gene, and by the complete absence of its product expression INI1 protein. The occurrence of MRT is limited to patients younger than 5 years, with more than 80% of children being under 2 years old.
Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on childhood cancer by discovering, developing, and disseminating new scientific knowledge. Our mission consists of three key areas — research, clinical, and education.
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