Dr. Kurmasheva to be Awarded Helen Freeborn Kerr Charitable Foundation Grant
The proposed research project is focused on the identification of modulators of a newly described PARP1-MGMT protein-protein interaction, which is demonstrated to enhance DNA repair through pathway crosstalk. Our ultimate goal is to develop a novel targeted therapy for cancers dependent on these pathways. Over the years, our group developed a large biobank of patient- and cell-derived pediatric xenograft tumor models. We will test the selected top lead molecules in some of these pediatric sarcoma models in our future studies.
Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on childhood cancer by discovering, developing, and disseminating new scientific knowledge. Our mission consists of three key areas — research, clinical, and education.
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