Home » Grants/Awards » Role of NRF2-ER and DNA damage stress response pathways in sensitivity of Ewing sarcoma cells to temozolomide and talazoparib.

Role of NRF2-ER and DNA damage stress response pathways in sensitivity of Ewing sarcoma cells to temozolomide and talazoparib.

Basic and Translational Science Award                                            

Source: GCCRI       

Period: 05/01/2017 – 04/30/2019                           

Title: Role of NRF2-ER and DNA damage stress response pathways in sensitivity of Ewing sarcoma cells to temozolomide and talazoparib.

Project Goal: Understand the role of ER homeostasis and DNA damage response pathway activation in Ewing sarcoma cells treated by temozolomide or talazoparib.

Role: Principal Investigator 

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on childhood cancer by discovering, developing, and disseminating new scientific knowledge. Our mission consists of three key areas — research, clinical, and education.

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