Understanding Functional Heterogeneity in Sarcomas

Funding Agency: CPRIT- First Time Tenure Track Award 

Title: Understanding Functional Heterogeneity in Sarcomas

Status: Active

Period: 2016-2020

Role: Principal Investigator

Grant Detail: Relapse is the major problem in the clinic and understanding how tumors change or evolve at relapse is the focus of this grant. We will use the power of modeling tumors in zebrafish in combination with patient derived cell lines and tumors and murine xenograft models to define tumor heterogeneity. Zebrafish tumor models provide a unique discovery platform for in vivo drug screens, imaging and genetics. From these studies we hope to identify new pathways to target in rhabdomyosarcoma and new sarcoma models we have generated and our currently characterizing.

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on childhood cancer by discovering, developing, and disseminating new scientific knowledge. Our mission consists of three key areas — research, clinical, and education.

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