American Journal of Physiology – Heart & Circulatory Physiology: The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure

November 15, 2014

Merry L. Lindsey, Richard A. Lange, Helen Parsons, Thomas Andrews, and Gregory J. Aune Abstract Since the modern era of cancer chemotherapy that began in the mid-1940s, survival rates for children afflicted with cancer have steadily improved from 10% to current rates that approach 80% (60). Unfortunately, many long-term survivors of pediatric cancer develop chemotherapy-related health effects; 25% are […]


American Journal of Physiology: The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure

November 14, 2014

Abstract Since the modern era of cancer chemotherapy that began in the mid-1940s, survival rates for children afflicted with cancer have steadily improved from 10% to current rates that approach 80% (60). Unfortunately, many long-term survivors of pediatric cancer develop chemotherapy-related health effects; 25% are afflicted with a severe or life-threatening medical condition, with cardiovascular […]


AACO: Introducing the ACCO’s Newest Board Members

October 1, 2014

Welcome to Dr. Greg Aune and Mr. Clint Janson, ACCO’s Newest Board Members! The ACCO is pleased to introduce Dr. Greg Aune and Mr. Clint Janson as the newest members of our Board of Directors, our volunteer leadership group dedicated to guiding and promoting the ACCO’s role as a grassroots leader in the childhood cancer community. Both Dr. […]


Congressional Childhood Cancer Caucus: Caucus Applauds NCI for Naming Pediatric Oncologist to Council of Research Advocates

September 30, 2014

National Cancer Institute Names UTHSCSA Pediatric Hematologist-Oncologist to Council of Research Advocates The National Cancer Institute (NCI) recently nominated a new member to its NCI Council of Research Advocates, Greg Aune, a pediatric hematologist-oncologist from The University of Texas Health Science Center at San Santonio. The announcement was made last Friday by NCI director Harold Varmus in a closed-door briefing on pediatric cancer for childhood cancer […]


UT Health SA Newsroom: Health Science Center pediatric oncologist appointed to national advocacy board

September 22, 2014

The National Cancer Institute has appointed a University of Texas Health Science Center pediatric hematologist-oncologist to its NCI Council of Research Advocates. On Friday, the White House held a closed briefing on pediatric cancer for childhood cancer advocates. During the keynote address, NCI Director Dr. Harold Varmus outlined the NCI commitment to pediatric cancer and […]


St. Baldrick’s: UT Health Science Center Pediatric Cancer Researcher Receives Grant in Groundbreaking Work for Childhood Cancer Survivors

August 13, 2014

UT Health Science Center Pediatric Cancer Researcher Receives Grant in Groundbreaking Work for Childhood Cancer Survivors A pediatric hematologist-oncologist from the University of Texas Health Science Center at San Antonio has been awarded a grant from the St. Baldrick’s Foundation to continue his groundbreaking work into the long-term problems that lifesaving chemotherapy can cause in […]



Cell Reports: Negative Elongation Factor Controls Energy Homeostasis in Cardiomyocytes

April 17, 2014

HaihuiPan1 KunhuaQin1 ZhanyongGuo23 YonggangMa4CraigApril7 XiaoliGao5T homas G.Andrews2 AlexBokov3 JianhuaZhang4 YidongChen23 Susan T.Weintraub5 Jian-BingFan7 DegengWang 23YanfenHu1 Gregory J.Aune26 Merry L.Lindsey4 RongLi1 Summary Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across multicellular genomes. However, the physiological impact of NELF on tissue homeostasis remains unclear. Here, we show that whole-body conditional deletion of the […]


Europe PMCP: Negative elongation factor controls energy homeostasis in cardiomyocytes. (Aune & Chen)

March 19, 2014

Abstract Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across multicellular genomes. However, the physiological impact of NELF on tissue homeostasis remains unclear. Here, we show that whole-body conditional deletion of the B subunit of NELF (NELF-B) in adult mice results in cardiomyopathy […]