Cancer Research: Chromosomal Breakpoints in Primary Colon Cancer Cluster at Sites of Structural Variants in the Genome

March 1, 2008

Jordi Camps, Marian Grade, Quang Tri Nguyen, Patrick Hörmann, Sandra Becker, Amanda B. Hummon, Virginia Rodriguez, Settara Chandrasekharappa, Yidong Chen, Michael J. Difilippantonio, Heinz Becker, B. Michael Ghadimi and Thomas Ried Abstract Genomic aberrations on chromosome 8 are common in colon cancer and are associated with lymph node and distant metastases as well as with disease susceptibility. This prompted us to generate a high-resolution map of genomic imbalances of chromosome 8 in 51 primary colon carcinomas using a custom-designed genomic array […]

Cancer Research: EpCAM and α-Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma

March 1, 2008

Taro Yamashita, Marshonna Forgues, Wei Wang, Jin Woo Kim, Qinghai Ye, Huliang Jia, Anuradha Budhu, Krista A. Zanetti, Yidong Chen, Lun-Xiu Qin, Zhao-You Tang, and Xin Wei Wang Abstract The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Recently, we have identified that a hepatic stem cell marker, epithelial cell adhesion molecule (EpCAM), may serve as an early biomarker of HCC because its expression is highly elevated in […]

Neoplasia: Comparison of Expression Profiles of Metastatic versus Primary Mammary Tumors in MMTV-Wnt-1 and MMTV-Neu Transgenic Mice1

February 1, 2008

Author links open overlay panelShixia Huang*†‡, Yidong Chen§, Katrina Podsypanina Abstract Distant metastases of human breast cancers have been suggested to be more different from each other than from their respective primary tumors, based on expression profiling. The mechanism behind this lack of similarity between individual metastases is not known. We used cDNA microarrays to […]

Molecular Cancer Research: Mouse Embryo Fibroblasts Lacking the Tumor Suppressor Menin Show Altered Expression of Extracellular Matrix Protein Genes

October 1, 2007

Abstract Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized primarily by endocrine tumors of the parathyroids, anterior pituitary, and enteropancreatic endocrine tissues. Affected individuals carry a germ-line loss-of-function mutation of the MEN1 gene, and tumors arise after the loss of the second allele. Homozygous loss of Men1 in the germline of […]

Cancer Biology & Therapy: Silencing of lactotransferrin expression by methylation in prostate cancer progression

July 11, 2007

Syed Shaheduzzaman, Anu Vishwanath, Bungo Furusato, Jennifer Cullen, Yongmei Chen, Lionel Bañez, Martin Nau, Lakshmi Ravindranath, Kee-Hong Kim, Ahmed Mohammed, Yidong Chen, Mathias Ehrich, Vasantha Srikantan, Isabell A. Sesterhenn, David G. McLeod, Maryanne Vahey,Gyorgy Petrovics,Albert Dobi &Shiv Srivastava Abstract Background: Cancer cells gain selection advantages by the coordinated silencing of protective and by the activation of […]

Clinical Cancer Research: Gene Expression Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma

February 1, 2007

Hu-Liang Jia, Qing-Hai Ye, Lun-Xiu Qin, Anuradha Budhu, Marshonna Forgues, Yidong Chen, Yin-Kun Liu, Hui-Chuan Sun, Lu Wang, Hong-Zhou Lu, Fang Shen, Zhao-You Tang and Xin Wei Wang Abstract Purpose: Hepatocellular carcinoma (HCC), common cancer worldwide, has a dismal outcome partly due to the poor identification of early-stage HCC. Currently, one-third of HCC patients present with low serum α-fetoprotein (AFP) levels, the only clinically available diagnostic marker for HCC. The aim of this study was to identify new diagnostic molecular markers […]

Technology in Cancer Research & Treatment: Wnt-1 is Dominant over Neu in Specifying Mammary Tumor Expression Profiles

December 1, 2006

Shixia Huang, PhD*, Katrina Podsypanina, PhD, Yidong Chen, PhD,  Weiyan Cai, Anna Tsimelzon, PhD, Susan Hilsenbeck, PhD, Yi Li, PhD Abstract Wnt-1 and Neu collaborate to induce mammary tumors in bitransgenic mice carrying both MMTV-Wnt-1 and MMTV-Neu. In this report, gene expression profiles were determined for tumors from these bitransgenic mice and compared with expression profiles of tumors from mice singly transgenic for MMTV-Wnt-1 or MMTV-Neu. While very different from tumors arising […]

Nature Methods: Sensitive and specific method for detecting G protein–coupled receptor mRNAs

November 19, 2006

Arne Hansen, Yidong Chen, Jason M Inman, Quang N Phan, Zhi-Qing Qi, Charlie C Xiang, Miklos Palkovits, Natasha Cherman, Sergei A Kuznetsov, Pamela G Robey, Eva Mezey & Michael J Brownstein Abstract G protein-coupled receptors (GPCRs) mediate the effects of extracellular signaling molecules in all the body’s cells. These receptors are encoded by scarce mRNAs; therefore, detecting their transcripts with conventional microarrays is difficult. We present a […]

The American Journal of Pathology: A Novel Role of Myosin VI in Human Prostate Cancer

November 1, 2006

Thomas A.Dunn*, Shenglin Chen*, Dennis A.Faith†, Jessica L.Hicks† Elizabeth A.Platz*‡,  Yidong  Chen§, Charles M.Ewing*, Jurga Sauvageot*, William B.Isaacs*†, Angelo M.De Marzo*†, Jun, Luo* Myosin VI is an actin motor that moves to the minus end of the polarized actin filament, a direction opposite to all other characterized myosins. Using expression microarrays, we identified myosin VI as one of the top […]