August 10, 2021
NCI Pediatric In Vivo Testing Program (U01), renewal for the previous PPTC (Pediatric Preclinical Testing Consortium). Grant period: July 2021-June 2026. Total dollar amount: $2,900,000 over 5 years. Abstract Cancer in children is rare with approximately 15,700 new cases diagnosed annually in children 21 years or younger in the U.S. [...]August 4, 2021
Craig Horbinski, Guifa Xi, Yufen Wang, Rintaro Hashizume, Mahesh Gopalakrishnan, Joanna J Phillips, Peter Houghton, Charles D James, John A Kalapurakal Abstract Background Meningiomas are the most common tumor arising within the cranium of adults. Despite surgical resection and radiotherapy, many meningiomas invade the brain, and many recur, often repeatedly. To date, no chemotherapy has proven effective against such tumors. Thus, there is […]
July 8, 2021
Panneerselvam Jayabal1, Fuchun Zhou1, Xiufen Lei1, XiuyeMa1, Barron Blackman1, Susan T.Weintraub23, Peter J.Houghton134, YuzuruShiio1235 Highlights • The autocrine signaling mediated by NELL2 maintains Ewing sarcoma cell growth • NELL2 signaling inhibits cdc42 and enhances EWS-FLI1 transcriptional output • NELL2-cdc42 signaling regulates the assembly and the stability of BAF complexes • Ewing sarcoma harbors cell populations […]
July 2, 2021
Authored by: Jun Luo, Yoshinobu Odaka, Zhu Huang, Bing Cheng, Wang Liu, Lin Li, Chaowei Shang, Chao Zhang, Yang Wu, Yan Luo, Shengyong Yang, Peter J. Houghton, Xiaofeng Guo, Shile Huang Abstract Dihydroartemisinin (DHA), an anti-malarial drug, has been shown to possess potent anticancer activity, partly by inhibiting the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) signaling. However, how DHA inhibits mTORC1 is still unknown. Here, [...]June 16, 2021
Congratulations to Angelina Vaseva, PhD, research assistant professor at Greehey Children’s Cancer Research Institute and the Department of Molecular Medicine, on being presented a 2021 2021 Voelcker Pilot Award. Dr. Vaseva’s project is “ Vertical Inhibition of the RAF-MEK-ERK Pathway in RAS-driven Rhabdomyosarcoma”. Her studies are centered on the development of novel targeted therapeutic strategies […]
June 7, 2021
Greehey CCRI would like to welcome the 2021 Donald G McEwen, Memorial Summer Undergraduate Research Program students. Gaby Ruban – Dr. Chen Misa Ito – Dr. Ignatius Jingsi Zhou – Dr. Kitagawa Hoang Dinh – Dr. Libich Gabriella Quintanilla – Dr. Penalva Shresth Arya – […]
June 4, 2021
Gilles Vassal, Peter J Houghton, Stefan M Pfister, Malcolm A. Smith, Huib N Caron, Xiao-Nan Li, David J Shields, Olaf Witt, Jan J Molenaar, Sara Colombetti, Julia Schuler, and Lou F Stancato Abstract Cancer remains the leading cause of disease-related death in children. For the many children who experience relapses of their malignant solid tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Preclinical drug testing to identify promising treatment elements that match the molecular make-up […]
April 30, 2021
by Holly L. Pacenta 1,2, Wendy Allen-Rhoades, 3, David Langenau, 4, Peter J. Houghton, 5, Charles Keller 6, Christine M. Heske, 7 , Michael D. Deel, 8, Corinne M. Linardic, 8 , Jack F. Shern 7, Elizabeth Stewart, 9, Brian Turpin, 10, Douglas J. Harrison, 11, Javed Khan, 12, Leo Mascarenhas, 13,14 , Stephen X. [...]April 13, 2021
Novel approach paves the way for a vast expansion in the number of drugs targeting osteosarcoma Abstract #LB008 HOUSTON — A preclinical study led by researchers at The University of Texas MD Anderson Cancer Center shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells […]
April 4, 2021
Abstract Developing new therapeutics for the treatment of childhood cancer has challenges not usually associated with adult malignancies. Firstly, childhood cancer is rare, with approximately 12,500 new diagnoses annually in the U.S. in children 18 years or younger. With current multimodality treatments, the 5-year event-free survival exceeds 80%, and 70% of patients achieve long-term “cure”, […]