Tiny molecule has big effect in childhood brain tumor studies

December 6, 2018

Sometimes small things make the biggest difference. A new study by UT Health San Antonio researchers found that a molecule thousands of times smaller than a gene are able to kill medulloblastoma, the most common childhood brain cancer.

Science Daily: Tiny molecule has big effect in childhood brain tumor studies

November 7, 2018

Sometimes small things make the biggest difference. A new study by UT Health San Antonio researchers found that a molecule thousands of times smaller than a gene are able to kill medulloblastoma, the most common childhood brain cancer. This tiny molecule, named MiR-584-5p, is quite efficient in its action. MiR-584-5p sensitizes cancer to chemotherapy and […]

Nature Communications: MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

October 31, 2018

Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton & Manjeet K. Rao Abstract Despite improvements in overall survival, only a modest percentage of patients survive high-risk medulloblastoma. The devastating side effects of radiation and chemotherapy substantially reduce the quality of life for surviving patients. Here, using genomic screens, we identified miR-584-5p as a […]

Science Advances: Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression

October 3, 2018

Subbarayalu Panneerdoss1,2,*, Vijay K. Eedunuri1,2,*, Pooja Yadav1,2, Santosh Timilsina1,2, Subapriya Rajamanickam2,3, Suryavathi Viswanadhapalli4, View ORCID ProfileNourhan Abdelfattah1,2, Benjamin C. Onyeagucha1,2, View ORCID ProfileXiadong Cui5, Zhao Lai2, View ORCID ProfileTabrez A. Mohammad2, View ORCID ProfileYogesh K. Gupta2,6, Tim Hui-Ming uang3, Yufei Huang5,†, View ORCID ProfileYidong Chen2,7,† and View ORCID ProfileManjeet K. Rao1,2,† Abstract The importance of RNA methylation in biological processes is an emerging focus of the investigation. We report that altering […]

Cancer Letters: Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells

July 1, 2018

AlfeuZanotto-Filhoac  SubapriyaRajamanickama  EvaLoranca  V. Pragathi Masamsettia  AparnaGorthiab  July CarolinaRomeroab  SonalTonapiab  Rosangela Mayer Gonçalvesc  Robert L.Reddickd  RaymondBenavidese  JohnKuhnde  YidongChenf  Alexander J.R.Bishopab Abstract Molecularly targeted compounds are emerging as a strategy to improve classical chemotherapy. Herein, we describe that using a low dose of the multikinase inhibitor sorafenib improves cyclophosphamide antitumor activity by inhibiting angiogenesis, metastasis, and promoting tumor healing in MDA-MB231 xenografts and the 4T1-12B syngeneic breast […]

International Journal of Genomics: Noncoding RNAs and Base Modifications: Epigenomic Players Implicated in Neurological Disorders and Tumorigenesis

June 13, 2018

Zhen Wei,1,2 Subbarayalu Panneerdoss,3,4 Santosh Timilsina,3,4 Jingting Zhu,1,5 Tabrez A. Mohammad,3 Zhi-Liang Lu,1,5 João Pedro de Magalhães,2 Yidong Chen,3,6 Rong Rong,1,5 Yufei Huang,6,7 Manjeet K. Rao,3,4 and Jia Meng1,5 Abstract Background. Compared with the well-studied 5-methylcytosine (m5C) in DNA, the role and topology of epitranscriptome m5C remain insufficiently characterized. Results. By analyzing transcriptome-wide m5C distribution in humans and mice, we show that the m5C modification is significantly enriched […]

UT Health SA Newsroom: Greehey Institute begins 2018 with new faculty studying children’s cancer

January 18, 2018

The Greehey Children’s Cancer Research Institute at UT Health San Antonio is on an impressive and rising trajectory as 2018 begins. This includes the recruitment of seven new faculty members, further bolstering the Alamo City’s thriving biosciences sector. Extramural funding for the Greehey Institute totaled $11.1 million in the state fiscal year ending Aug. 31, […]

Nature Communications: Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells

September 19, 2017

Subbarayalu Panneerdoss, Suryavathi Viswanadhapalli, Nourhan Abdelfattah, Benjamin C. Onyeagucha, Santosh Timilsina, Tabrez A. Mohammad, Yidong Chen, Michael Drake, Kristiina Vuori, T. Rajendra Kumar & Manjeet K. Rao Abstract Phagocytic clearance of apoptotic germ cells by Sertoli cells is vital for germ cell development and differentiation. Here, using a tissue-specific miRNA transgenic mouse model, we show that interaction between miR-471-5p and autophagy member proteins regulates the clearance of […]