Familial Cancer: Highly aggressive thoracic desmoid tumors in adolescent siblings with fatal outcomes in an FAP kindred: a need for increased vigilance and intervention in at-risk AYAs

April 13, 2020

Mohamed M. Gad, Anne-Marie Langevin, Aaron J. Sugalski & Gail E. Tomlinson Abstract Desmoid tumors are a manifestation of familial adenomatous polyposis (FAP), associated with mutation of the APC gene. Although considered benign tumors, desmoids can be aggressive and cause considerable morbidity. Known risk factors for desmoid tumor growth include the location of mutations within the APC gene, family […]

Frontiers in Biosciences (Elite Ed) Cytogenetics of hepatoblastoma

January 2, 2020

Gail E Tomlinson 1 Abstract The cytogenetics of hepatoblastoma demonstrate recurring events which include whole chromosome trisomies, most commonly trisomy of chromosome 2, 8, or 10. In addition, unbalanced translocations involving a breakpoint on the proximal short arm of chromosome 1 are observed which results in a duplication of the long arm of chromosome 1q. The […]

San Antonio Magazine: Top Doctors (Tomlinson)

January 1, 2020

Professor of Pediatrics, Greehey distinguished chair in genetics and cancer; division director, pediatric hematology-oncology; co-director, population science and prevention program, Mays Cancer Center/UT Health When Dr. Gail Tomlinson decided to specialize in pediatric oncology and hematology, she saw it as a way to ensure she was always learning while still making a direct impact on […]

GRACIAS Texas: Empowering South Texas’ underserved population (Tomlinson)

December 26, 2019

Senior health educator Anna Maria Pulido Saldivar, who is based in Laredo, educates community members in South Texas about cancer prevention and screening. Mays Cancer Center Annual Report Knowledge is power, and with today’s advances in science, knowing the family history of cancer through genetic testing can save lives. For millions of underserved minority populations, […]

Human Mutation: Clinical spectrum of individuals with pathogenic NF1 missense variants affecting p.Met1149, p.Arg1276, and p.Lys1423: genotype-phenotype study in neurofibromatosis type 1

October 8, 2019

Magdalena Koczkowska 1, Tom Callens 1, Yunjia Chen 1, Alicia Gomes 1, Alesha D Hicks 1, Angela Sharp 1, Eric Johns 1, Kim Armfield Uhas 2, Linlea Armstrong 3, Katherine Armstrong Bosanko 4, Dusica Babovic-Vuksanovic 5, Laura Baker 6, Donald G Basel 7, Mario Bengala 8, James T Bennett 9, Chelsea Chambers 10, Lola K Clarkson 11, Maurizio Clementi 12, Fanny M Cortés 13, Mitch Cunningham 14, M Daniela D’Agostino 15, Martin B Delatycki 16, Maria C Digilio 17, Laura Dosa 18, Silvia Esposito 19, Stephanie Fox 15, Mary-Louise Freckmann 20, Christine Fauth 21, Teresa Giugliano 22, Sandra Giustini 23, Allison Goetsch 24, Yael Goldberg 25, Robert S Greenwood 26, Cristin Griffis 7, Karen W Gripp 6, Punita Gupta 27, Eric Haan 28, Rachel K Hachen 29, Tamara L Haygarth 30, Concepción Hernández-Chico 31, Katelyn […]

Pediatric Blood & Cancer: Characterization of pediatric hepatocellular carcinoma reveals genomic heterogeneity and diverse signaling pathway activation

April 11, 2019

Katherine Haines 1, Stephen F Sarabia 2 3, Karla R Alvarez 2 3, Gail Tomlinson 4, Sanjeev A Vasudevan 3 5, Andras A Heczey 3 6, Angshumoy Roy 2 3, Milton J Finegold 2, D Williams Parsons 1 3 6, Sharon E Plon 1 3 6, Dolores López-Terrada 2 3 Abstract Background: Pediatric hepatocellular carcinoma (HCC) is a rare liver tumor in children with a poor prognosis. Comprehensive molecular profiling to understand the underlying genomic drivers of this tumor has not been completed, and it is unclear […]

YouTube: Experimental Biology TV, WebsEdgeMedicine

April 4, 2019

“Cancers in children are rare, and the genetics and epigenetic causes are very different from those of adults. Consequently, the study of the etiology and potential therapies for these tumors requires intensive research. The majority of children diagnosed with cancer survive their disease, but the long-term consequences of current treatments lead to lifelong health issues. […]

UT Health SA Newsroom: UT Health San Antonio physician-researcher contributes to international screening guidelines for rare pediatric cancers

August 2, 2018

SAN ANTONIO (Aug. 2, 2017) ―Approximately 10 percent of childhood cancer can be attributed to genetics. While genomic analysis has been used for some time to identify the risk of inherited cancer in adults, scientists are now using genomic analysis to identify genetic risk factors and to diagnose cancer at an early age in children. […]