UT Health SA Newsroom: UT Health San Antonio physician-researcher contributes to international screening guidelines for rare pediatric cancers

August 2, 2018

SAN ANTONIO (Aug. 2, 2017) ―Approximately 10 percent of childhood cancer can be attributed to genetics. While genomic analysis has been used for some time to identify the risk of inherited cancer in adults, scientists are now using genomic analysis to identify genetic risk factors and to diagnose cancer at an early age in children. […]

Familial Cancer: Discovery of mutations in homologous recombination genes in African-American women with breast cancer

September 2, 2017

Yuan Chun Ding 1, Aaron W Adamson 1, Linda Steele 1, Adam M Bailis 2, Esther M John 3 4, Gail Tomlinson 5 6, Susan L Neuhausen 7 Abstract African-American women are more likely to develop aggressive breast cancer at younger ages and experience poorer cancer prognoses than non-Hispanic Caucasians. Deficiency in the repair of DNA by homologous recombination (HR) is associated with cancer development, suggesting that mutations in genes […]

Clinical Cancer Research: Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood

July 1, 2017

Maria Isabel Achatz, Christopher C. Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D. Foulkes, Christian P. Kratz, Roland P. Kuiper, Jordan R. Hansford, Hector Salvador Hernandez, Katherine L. Nathanson, Wendy K. Kohlmann, Leslie Doros, Kenan Onel, Kami Wolfe Schneider, Sarah R. Scollon, Uri Tabori, Gail E. Tomlinson, D. Gareth R. Evans and Sharon E. Plon Abstract Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in […]

Clinical Cancer Research: Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma

July 1, 2017

Jennifer M Kalish 1, Leslie Doros 2, Lee J Helman 3, Raoul C Hennekam 4, Roland P Kuiper 5, Saskia M Maas 6, Eamonn R Maher 7, Kim E Nichols 8, Sharon E Plon 9, Christopher C Porter 10, Surya Rednam 9, Kris Ann P Schultz 11, Lisa J States 12, Gail E Tomlinson 13, Kristin Zelley 14, Todd E Druley 15 Abstract A number of genetic syndromes have been linked to increased risk for Wilms tumor (WT), hepatoblastoma (HB), and other embryonal tumors. Here, we […]

Clinical Cancer Research: Multiple Endocrine Neoplasia and Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood

July 1, 2017

Jonathan D Wasserman 1, Gail E Tomlinson 2, Harriet Druker 3, Junne Kamihara 4, Wendy K Kohlmann 5, Christian P Kratz 6, Katherine L Nathanson 7, Kristian W Pajtler 8 9, Andreu Parareda 10, Surya P Rednam 11, Lisa J States 12, Anita Villani 3, Michael F Walsh 13, Kristin Zelley 14, Joshua D Schiffman 15 Abstract Children and adolescents who present with neuroendocrine tumors are at extremely high likelihood of having an underlying germline predisposition for the multiple endocrine neoplasia (MEN) syndromes, including MEN1, […]

PloS One: De-regulated microRNAs in pediatric cancer stem cells target pathways involved in cell proliferation, cell cycle and development

April 4, 2017

Patricia C Sanchez-Diaz 1, Tzu-Hung Hsiao, Judy C Chang, Dong Yue, Mimi C Tan, Hung-I Harry Chen, Gail E Tomlinson, Yufei Huang, Yidong Chen, Jaclyn Y Hung Abstract Background: microRNAs (miRNAs) have been implicated in the control of many biological processes and their deregulation has been associated with many cancers. In recent years, the cancer stem cell (CSC) concept has been applied to many cancers including […]

Journal of Exposure Science & Environmental Epidemiology: Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children’s Oncology Group

March 8, 2017

Amanda E Janitz, Gurumurthy Ramachandran, Gail E Tomlinson, Mark Krailo, Michaela Richardson & Logan Spector Abstract Little is known about the etiology of hepatoblastoma. We aimed to confirm the results of a previous study evaluating the association between parental occupational exposures and hepatoblastoma. In our case-control study, we identified cases (n=383) from the Children’s Oncology Group […]

Hepatology: Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups

October 24, 2016

Pavel Sumazin, Yidong Chen, Lisa R. Treviño Stephen F. Sarabia Oliver A. Hampton Kayuri Patel Toni‐Ann Mistretta Barry Zorman Patrick Thompson Andras Heczey Sarah Comerford David A. Wheeler Murali Chintagumpala Rebecka Meyers Dinesh Rakheja Milton J. Finegold Gail Tomlinson D. Williams Parsons Dolores López‐Terrada Abstract Despite being the most common liver cancer in children, hepatoblastoma (HB) is a rare neoplasm. Consequently, few pretreatment tumors have been molecularly profiled, and there are no validated […]

Hyundai Hope on Wheels Awards $250,000 Research Grant to Ut Health Science Center San Antonio in Honor of National Childhood Cancer Awareness Month

September 12, 2016

San Antonio, TX – September 12 – Hyundai Hope On Wheels® (HHOW) and San Antonio-area Hyundai dealers will present UT Health Science Center San Antonio with a $250,000 Scholar Grant to be used to improve care and increase treatment options for kids with cancer. UT Health Science Center San Antonio was one of 24 recipients across the […]