Biological Psychology: The serotonin transporter gene and startle response during nicotine deprivation

January 1, 2011

Jennifer A Minnix 1, Jason D Robinson, Cho Y Lam, Brian L Carter, Jennifer E Foreman, David J Vandenbergh, Gail E Tomlinson, David W Wetter, Paul M Cinciripini Abstract Affective startle probe methodology was used to examine the effects of nicotine administration and deprivation on emotional processes among individuals carrying at least one s allele versus those with the l/l genotype of the 5-Hydroxytryptamine […]

Cancer Genetics: Identification of genetic susceptibility to childhood cancer through analysis of genes in parallel

January 1, 2011

Sharon E Plon 1, David A Wheeler, Louise C Strong, Gail E Tomlinson, Michael Pirics, Qingchang Meng, Hannah C Cheung, Phyllis R Begin, Donna M Muzny, Lora Lewis, Jaclyn A Biegel, Richard A Gibbs Erratum in Cancer Genet. 2011 May;204(5):284 Abstract Clinical cancer genetic susceptibility analysis typically proceeds sequentially, beginning with the most likely causative gene. The process is time-consuming and the yield is low, particularly for [...]

Cancer Research: Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction

December 1, 2010

Antonis C Antoniou 1, Jonathan Beesley, Lesley McGuffog, Olga M Sinilnikova, Sue Healey, Susan L Neuhausen, Yuan Chun Ding, Timothy R Rebbeck, Jeffrey N Weitzel, Henry T Lynch, Claudine Isaacs, Patricia A Ganz, Gail Tomlinson, Olufunmilayo I Olopade, Fergus J Couch, Xianshu Wang, Noralane M Lindor, Vernon S Pankratz, Paolo Radice, Siranoush Manoukian, Bernard Peissel, Daniela Zaffaroni, Monica Barile, Alessandra Viel, Anna Allavena, Valentina Dall’Olio, Paolo Peterlongo, Csilla I Szabo, Michal Zikan, Kathleen Claes, Bruce Poppe, Lenka Foretova, Phuong L Mai, Mark H Greene, Gad Rennert, Flavio Lejbkowicz, Gord Glendon, Hilmi Ozcelik, Irene L […]

Breast Cancer Research & Treatment: Germline mutations in PALB2 in African-American breast cancer cases

November 27, 2010

Yuan Chun Ding 1, Linda Steele, Li-Hao Chu, Karen Kelley, Helen Davis, Esther M John, Gail E Tomlinson, Susan L Neuhausen Abstract Breast cancer incidence is lower in African Americans than in Caucasian Americans. However, African-American women have higher breast cancer mortality rates and tend to be diagnosed with the earlier-onset disease. Identifying factors correlated to the racial/ethnic variation in the epidemiology of […]

Blood: Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias

November 25, 2010

Hima Bansal 1, Sanjay Bansal, Manjeet Rao, Kevin P Foley, Jim Sang, David A Proia, Ronald K Blackman, Weiwen Ying, James Barsoum, Maria R Baer, Kevin Kelly, Ronan Swords, Gail E Tomlinson, Minoo Battiwalla, Francis J Giles, Kelvin P Lee, Swaminathan Padmanabhan Abstract The aberrant overexpression of Wilms tumor 1 (WT1) in myeloid leukemia plays an important role in blast cell survival and resistance to chemotherapy. High expression of WT1 is also […]

Breast Cancer Research Treatment: Occult ovarian cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers

February 24, 2010

Susan M Domchek 1, Tara M Friebel, Judy E Garber, Claudine Isaacs, Ellen Matloff, Rosalind Eeles, D Gareth Evans, Wendy Rubinstein, Christian F Singer, Stephen Rubin, Henry T Lynch, Mary B Daly, Jeffrey Weitzel, Patricia A Ganz, Gabriella Pichert, Olufunmilayo I Olopade, Gail Tomlinson, Nadine Tung, Joanne L Blum, Fergus Couch, Timothy R Rebbeck Abstract Risk-reducing salpingo-oophorectomy (RRSO) is widely used for cancer risk reduction in BRCA1 or BRCA2 (BRCA1/2) mutation carriers. Occult ovarian/fallopian tube cancers […]

Pediatric Blood & Cancer: Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor

December 1, 2009

Tina T-L Chen 1, Dinesh Rakheja, Jaclyn Y Hung, Peter J Hornsby, Piotr Tabaczewski, Marcio Malogolowkin, James Feusner, Frank Miskevich, Roger Schultz, Gail E Tomlinson Abstract Background: Hepatoblastoma is a rare malignancy of childhood. The scarcity of adequate cell models has limited our understanding of this tumor. Here we describe and characterize a new human liver tumor cell line, Hep293TT, derived from an aggressive childhood hepatoblastoma. […]

Breast Cancer Research Treatment: Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers

November 18, 2009

Amanda B Spurdle 1, Paul Fahey, Xiaoqing Chen, Lesley McGuffog, kConFab; Douglas Easton, Susan Peock, Margaret Cook, EMBRACE; Jacques Simard, INHERIT; Tim R Rebbeck, MAGIC; Antonis C Antoniou, Georgia Chenevix-Trench Abstract The GSTP1, GSTM1, and GSTT1 detoxification genes all have functional polymorphisms that are common in the general population. A single study of 320 BRCA1/2 carriers previously assessed their effect in BRCA1 or BRCA2 mutation carriers. This study showed no […]

BMC Research: Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

October 20, 2009

Susan L Neuhausen 1, Sean Brummel, Yuan Chun Ding, Christian F Singer, Georg Pfeiler, Henry T Lynch, Katherine L Nathanson, Timothy R Rebbeck, Judy E Garber, Fergus Couch, Jeffrey Weitzel, Steven A Narod, Patricia A Ganz, Mary B Daly, Andrew K Godwin, Claudine Isaacs, Olufunmilayo I Olopade, Gail Tomlinson, Wendy S Rubinstein, Nadine Tung, Joanne L Blum, Daniel L Gillen Abstract Introduction: Women who carry mutations in BRCA1 and BRCA2 have a substantially increased risk of developing breast […]

Cancer Research: Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers

July 1, 2009

Timothy R Rebbeck 1, Nandita Mitra, Susan M Domchek, Fei Wan, Shannon Chuai, Tara M Friebel, Saarene Panossian, Amanda Spurdle, Georgia Chenevix-Trench, kConFab; Christian F Singer, Georg Pfeiler, Susan L Neuhausen, Henry T Lynch, Judy E Garber, Jeffrey N Weitzel, Claudine Isaacs, Fergus Couch, Steven A Narod, Wendy S Rubinstein, Gail E Tomlinson, Patricia A Ganz, Olufunmilayo I Olopade, Nadine Tung, Joanne L Blum, Roger Greenberg, Katherine L Nathanson, Mary B Daly Abstract Inherited BRCA1/2 mutations confer elevated ovarian cancer risk. Knowledge of […]