International Journal of Cancer: Profiles of brain metastases: Prioritization of therapeutic targets

December 1, 2018

Sherise D Ferguson 1, Siyuan Zheng 2, Joanne Xiu 3, Shouhao Zhou 4, Mustafa Khasraw 5, Priscilla K Brastianos 6, Santosh Kesari 7, Jethro Hu 8, Jeremy Rudnick 8, Michael E Salacz 9, David Piccioni 10, Suyun Huang 1, Michael A Davies 11, Isabella C Glitza 11, John V Heymach 12, Jianjun Zhang 12, Nuhad K Ibrahim 13, John F DeGroot 14, Joseph McCarty 1, Barbara J O’Brien 14, Raymond Sawaya 1, Roeland G W Verhaak 2, Sandeep K Reddy 3, Waldemar Priebe 15, Zoran Gatalica 3, David Spetzler 3, Amy B Heimberger 1 Abstract We sought to compare the tumor profiles of brain metastases from common cancers […]

UT Health SA Newsroom: CPRIT awards millions to UT Health San Antonio

August 18, 2018

Cancer prevention programs and initiatives to recruit faculty to UT Health San Antonio got a $3.5 million boost from the Cancer Prevention & Research Institute of Texas (CPRIT). The awards, announced Aug. 16, bringing total funding to UT Health San Antonio by CPRIT to about $74.6 million since the program began in 2008. The Mays […]

Cell Report: Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma

July 10, 2018

Seçkin Akgül 1, Yinghua Li 2, Siyuan Zheng 3, Marcel Kool 4, Daniel M Treisman 5, Chaoyang Li 2, Yuan Wang 2, Susanne Gröbner 4, Tsuneo Ikenoue 6, Yiping Shen 7, Sandra Camelo-Piragua 8, Gerald Tomasek 9, Sebastian Stark 4, Vinay Guduguntla 9, James F Gusella 7, Kun-Liang Guan 6, Stefan M Pfister 10, Roel G W Verhaak 11, Yuan Zhu 12 Abstract Most human cancers arise from stem and progenitor cells by the sequential accumulation of genetic and epigenetic alterations, while cancer modeling typically requires simultaneous multiple oncogenic events. Here, we […]

Nature Genetics: Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

April 23, 2018

Ana C deCarvalho 1, Hoon Kim 2, Laila M Poisson 3, Mary E Winn 4, Claudius Mueller 5, David Cherba 4, Julie Koeman 6, Sahil Seth 7, Alexei Protopopov 7, Michelle Felicella 8, Siyuan Zheng 9, Asha Multani 10, Yongying Jiang 7, Jianhua Zhang 7, Do-Hyun Nam 11 12 13, Emanuel F Petricoin 5, Lynda Chin 7 9, Tom Mikkelsen 14 15, Roel G W Verhaak 16 Abstract To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft […]

UT Health SA Newsroom: Greehey Institute begins 2018 with new faculty studying children’s cancer

January 18, 2018

The Greehey Children’s Cancer Research Institute at UT Health San Antonio is on an impressive and rising trajectory as 2018 begins. This includes the recruitment of seven new faculty members, further bolstering the Alamo City’s thriving biosciences sector. Extramural funding for the Greehey Institute totaled $11.1 million in the state fiscal year ending Aug. 31, […]

Neuro-Oncology: Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma

January 1, 2018

Shaofang Wu, Shuzhen Wang, Feng Gao, Luyuan Li, Siyuan Zheng, W K Alfred Yung, Dimpy Koul Abstract Background Oncogenic activation of phosphatidylinositol-3 kinase (PI3K) signaling plays a pivotal role in the development of glioblastoma (GBM). However, pharmacological inhibition of PI3K has so far not been therapeutically successful due to adaptive resistance through a rapid rewiring of cancer cell signaling. Here we […]

CPRIT Grant: Recruitment of First-Time, Tenure-Track Faculty Members

August 16, 2017

“Big Data” is a driving force in cancer research today. Sifting through the data from thousands of cancer genomes will help researchers understand what drives cancer, and help them make predictions about therapies that will be most beneficial to individual patients. To help make sense of these data, and in particular, to apply the findings […]