Cancer Research: Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity (Rao, Zhou, Hromas, Sung, Chen, et al)
December 3, 2025Deepika Singh Benjamin C. Onyeagucha Daisy Medina Panneerdoss Subbarayalu Rahul Mojidra Dongwen Lv Mukund Bhandari Santosh Timilsina Prabhakar Pitta Venkata Jian Yu. Huang Saif Nirzhor Shahad Abdulsahib Jack Yancy. Prochnau Chris TP. Do Subapriya Rajam …
Cancer Research: Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity (Rao, Zhou, Hromas, Sung, Chen
December 3, 2025Deepika Singh Benjamin C. Onyeagucha Daisy Medina Panneerdoss Subbarayalu Rahul Mojidra Dongwen Lv Mukund Bhandari Santosh Timilsina Prabhakar Pitta Venkata Jian Yu. Huang Saif Nirzhor Shahad Abdulsahib Jack Yancy. Prochnau Chris TP. Do Subapriya Rajam …
Molecular Cell: Deubiquitinases cleave ubiquitin-fused ribosomal proteins and physically counteract their targeting to the UFD pathway (Olsen)
December 1, 2025Stephanie Patchett 1 5, Seyed Arad Moghadasi 1 5, Ankita Shukla 2, Farid El Oualid 3, Beatrix M. Ueberheide 1 4, Shaun K. Olsen 2, Tony T. Huang 1 6 Highlights Cleavage-resistant ubiquitin-fused human ribosomal proteins (RPs) impair ribosome function U …
Science Advances: Ligand-receptor interactions induce and mediate regulatory functions of BATF3+ B cells (Chen Lab, Zheng Lab)
November 12, 2025Hui Yan Rui Wang Suryavathi Viswanadhapalli Christian Cervantes Funan He Shuai Wu Azad Khosh Weiwei Luo Jingwei Wang Maria J. Fernandez Uday P. Pratap Mustafa Khan Karli Hinton Sai Eashan Vankamamidi Dariela Perez Carlos E. Rivera Harshita B. Gup …
ACS Medicinal Chemistry Letters: Identification and Exploration of a Series of SARS-Cov-2 MPro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group (Olsen)
November 10, 2025Emma Clyde-Allen Mikołaj Zmudzinski Mohammad Afsar Ciyana James Anindita Nayak Digant Nayak Priscila dos Santos Bury Dirk Jochmans Johann Neyts Christopher J. Scott Shaun K. Olsen Marcin Drag Rich Williams* Abstract Starting from a simple scaffold hopp …
Molecular Medicine: Selective inhibition of BRAF and CRAF sensitizes NF1-deficient malignant peripheral nerve sheath tumors to MEK inhibitors (Zheng, Kitagawa Lab)
October 2, 2025Jiawan Wang, Arnab Sarkar, Natalia Garcia, Lindy Zhang, Ana Calizo, Alla Lisok, Katia Campos, Funan He, Nishanth Punjaala, Teresa Marple, Kai Pollard, Siyuan Zheng, Calixto-Hope G. Lucas, Vesselina G. Cooke, Christine A. Pratilas …
Nature Structural & Molecular Biology: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer (Olsen Lab, Sung Lab)
September 26, 2025Anindita Nayak, Digant Nayak, Lijia Jia, Eliza A. Ruben, Suryavathi Viswanadhapalli, Priscila dos Santos Bury, Khaled Mohamed Nassar, Corey H. Yu, Anna A. Tumanova, Caleb M. Stratton, Pirouz Ebadi, Dmitri N. Ivanov, Patrick Sung, Ratna K. Vadlamudi, El …
BioRxiv: Phosphoregulation of RAD51AP1 function in homology-directed repair (Sung Lab)
September 22, 2025Neelam Sharma, Mollie Uhrig, Youngho Kwon, Patrick Sung, Claudia Wiese ABSTRACT Homology-directed DNA repair (HDR) is critical for genome stability and tumor suppression. HDR is initiated by the RAD51 single-stranded (ss)DNA nucleoprotein filament whi …
Protein Science: Molecular basis of EWS interdomain self-association and its role in condensate formation (Libich Lab)
September 22, 2025Erich J. Sohn, Kandarp A. Sojitra, Leticia Rodrigues, Xiaoping Xu, Bess Frost, Jeetain Mittal, David S. Libich Abstract Ewing sarcoma, the second most common pediatric bone and soft tissue cancer, is caused by the aberrant fusion of the RNA-binding pro …
Trends in Biochemical Sciences: E3 Ubiquitin Ligases in Signaling, Disease, and Therapeutics (Olsen)
September 15, 2025Pirouz Ebadi 1, Caleb M Stratton 1, Shaun K Olsen 2 Abstract The ubiquitin-proteasome system (UPS) is a central regulator of protein turnover and signaling, with E3 ubiquitin ligases conferring substrate specificity and chain-type control. Recent advan …
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