Greehey CCRI Archives

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Open Access Government: Developing novel therapies for childhood cancers (Houghton)

September 19, 2023

Dr Peter J Houghton from Greehey Children’s Cancer Research Institute discusses the obstacles in developing new treatments for childhood cancers and new approaches in preclinical testing. In my previous article for Open Access Government, I focused on …


Cancers: Dysregulation of Type I Interferon (IFN-I) Signaling: A Potential Contributor to Racial Disparity in Hepatocellular Carcinoma (HCC) (Lai)

September 12, 2023

            Saranya Chidambaranathan Reghupaty 1,†,Sadia Kanwal 2, Rachel G. Mendoza 3, Eva Davis 4,Haiwen Li 2, Zhao Lai 5, Mikhail G. Dozmorov 6 ,Milton Omar Faison 7, Rafat Ali Siddiqui 2, *Devanand Sarkar 8,* Simple Su …


Texas Public Radio: “Fighting childhood cancer in San Antonio” (Aune)

September 8, 2023

September is Childhood Cancer Awareness Month, a time to raise awareness of this devastating disease and to support the children and families who are affected by it. Childhood cancer is the leading cause of death by disease for children under the age o …


Embro Reports: Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping (Chen)

September 5, 2023

Abstract Bromodomain-containing protein 4 (BRD4) is overexpressed and functionally implicated in various myeloid malignancies. However, the role of BRD4 in normal hematopoiesis remains largely unknown. Here, utilizing an inducible Brd4 knockout mouse m …


Allison Grimes, M.D., MSCI, Awarded $999K CPRIT Grant to Study “Expansion of HPV Vaccination Among Survivors of Childhood Cancer”

August 24, 2023

Lay Summary Human papillomavirus (HPV) is known to cause most cervical, anal, and oropharyngeal cancers, and a large proportion of vaginal, vulvar, and penile malignancies. Every year nearly 39,000 new cases of HPV-related cancers are diagnosed in the …


Science Reports: Sex-dependent differences in the genomic profile of lingual sensory neurons in naïve and tongue-tumor bearing mice (Chen, Lai)

August 14, 2023

Tarek Ibrahim, Ping Wu, Li-Ju Wang, Chang Fang-Mei, Josue Murillo, Jaclyn Merlo, Sergey S. Shein, Alexei V. Tumanov, Zhao Lai, Korri Weldon, Yidong Chen & Shivani Ruparel Abstract Mechanisms of sex-dependent orofacial pain are widely understudied. …


Dr. Gupta to Present at Cold Spring Harbor Laboratory Meeting on Eukaryotic mRNA Processing, August 22-26, 2023

August 2, 2023

Click on image below for full agenda _________________________________________________________ Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to …


Nucleic Acids Research: TLK1-Mediated RAD54 Phosphorylation Spatio-Temporally Regulates Homologous Recombination Repair (Chen, Sung)

July 13, 2023

Ishita Ghosh, Youngho Kwon, Aida Badamchi Shabestari, Rupesh Chikhale, Jing Chen, Claudia Wiese, Patrick Sung, Arrigo De Benedetti Abstract Environmental agents like ionizing radiation (IR) and chemotherapeutic drugs can cause severe damage to the DNA, …


Midwest AViDD Center announces funding for six high-potential projects to further antiviral drug discovery (Gupta Lab et al)

July 10, 2023

MINNEAPOLIS/ST. PAUL (07/05/2023) – To accelerate the Midwest Antiviral Drug Discovery (AViDD) Center’s mission to develop therapeutics for viruses with pandemic potential, the Center today announced $3 million in funding for six additional projects ov …


Pediatric Hematology & Oncology: Circulating tumor DNA sequencing of pediatric solid and brain tumor patients: An institutional feasibility study (Tomlinson)

June 27, 2023

Ross Mangum, Jacquelyn Reuther ,Koel Sen Baksi Ilavarasi Gandhi, Ryan C. Zabriskiec, Alva Recinos, , Robin Raesz-Martinez, Frank Y. Lin, Samara L. Potter, Andrew C. Sher, Stephen F. Kralik, Carrie A. Mohila, Murali M. Chintagumpala, Donna Muzny, Jianho …


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