Ubiquitylation of DNA polymerase β via atypical K27 chains signals a DNA damage response (Sung Lab)
April 16, 2026Qingming Fang , Christopher A Koczor , Wynand P Roos , Steve McClellan , Joel F Andrews , Robert W Sobol Abstract DNA polymerase β (Polβ) stability is tightly regulated by specific binding partners that prevent its proteasomal degradation. Ubiquit …
David Libich, PhD Awarded Five‑Year, $2.1 million NIH Grant to Study “Protein Intrinsic Disorder in Genome Regulation.”
April 13, 2026Every cell in the body must carefully protect its DNA to stay healthy. To do this, cells coordinate several essential tasks, such as turning genes on and off, processing genetic information, and repairing damaged DNA. These activities occur within the …
Journal of Biological Chemistry: Structural Basis for the Mechanism and Stability of the EEPD1 5’ Endonuclease (Gupta Lab)
April 10, 2026Robert A. Hromas1,∗ guptay@uthscsa.edu ∙ Aruna S. Jaiswal1,∗ ∙ Anurag Misra2,∗ ∙ Yaxia Yuan3 ∙ Daohong Zhou3 ∙ John I. Beckman2 ∙ Shailee Arya2 ∙ Adhishree Chidambaram2 ∙ Alexander B. Taylor2 ∙ Wendell Griffith4 ∙ Arunima Jaiswal1 ∙ Elizabeth A. Willia …
Graduate School of Biomedical Sciences (GSBS) Outstanding Student Awards
April 8, 2026We at Greehey CCRI are proud to celebrate the exceptional achievements of our GSBS students, whose leadership and research are making a meaningful impact across our academic community. 🌟 GSBS Outstanding Student Leadership Award: Jack Prochnau The Outs …
Drug Target Review: Why PARP inhibitors fail: key role of the CST complex in BRCA1-deficient cancers (Sung)
April 8, 2026Scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio), in collaboration with Dana-Farber Cancer Institute at Harvard Medical School, Columbia University and Irving Medical Center, have made a critical breakt …
Nature Structural & Molecular Biology: Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex (Sung Lab, Rao Lab)
April 1, 2026Abstract Senataxin (SETX), an RNA–DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX–BRCA1 resolves transcription-associated R-loops to prevent deleterious outco …
Cancers: Biological Advances and Current Challenges for Pediatric Rhabdomyosarcoma (Houghton, Ignatius, et al)
March 30, 2026by Katie E. Hebron, Patience Odeniyide, Yun Wei, Berkley E. Gryder, G. Barr, Dana L. Casey, Eleanor Y. Chen, Brian D. Crompton, Filemon S. Dela Cruz, Adam D. Durbin, Heide L. Ford, Susanne A. Gatz, Mark E. Hatley, Anton G. Henssen, Simone Hettmer, Pete …
BioRxiv: Diverse Mechanisms of SMARCB1 Inactivation and Genome Maintenance Defects in Ultra-Rare Malignant Rhabdoid Tumors (Kurmasheva Lab, Chen, Lai)
March 27, 2026Elizabeth Rasmussen, Elena Mironova, Zhao Lai, Kendra Maaß, Stefanie Volz, Dias Kurmashev, Stefan M. Pfister, Yidong Chen, Raushan T. Kurmasheva ABSTRACT Malignant rhabdoid tumors (MRTs) are extremely rare and highly aggressive pediatric cancers classi …
BioRxiv: Intrinsically disordered SERBP1 regulates translation through topology-driven G-quadruplex recognition (Libich Lab)
March 19, 2026Antoine Baudin, Hoang H. Dinh, Kira Breunig, Xuifen Lei, Xiaoping Xu, View Luiz O. Penalva, David S. Libich Abstract Serpine mRNA-binding protein 1 (SERBP1) is an intrinsically disordered RNA-binding protein that regulates translat …
iScience: Predicting and interpreting protein and phosphoprotein abundance from pan-cancer and single-cell transcriptomes (Chen Lab)
March 12, 2026Hui-Mei Tsai1,2,3,12 ∙ Tzu-Hung Hsiao2,4,5,12 ∙ Yu-Chiao Chiu6,7 ∙ Yufei Huang6,7 ∙ Eric Y. Chuang1,8,9,10 chuangey@ntu.edu.tw ∙ Yidong Chen3,11,13 cheny8@uthscsa.edu Highlights • DeepGxP provides a framework to translate transcriptomes into proteomic …
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