Bioinformatics Advances: shinyDeepGxP: a user-friendly R shiny app for predicting surface protein abundance from scRNA-seq expression using deep learning in blood cells (Chen)
November 6, 2026Hui-Mei Tsai , Tzu-Hung Hsiao , Yu-Ching Hsu , Li-Ju Wang , Yu-Chiao Chiu , Eric Y Chuang , Yidong Chen Abstract Motivation Accurately understanding immune cell heterogeneity and function in single-cell datasets requires protein-level information, whic …
iScience: MAPK-driven MYC/p21 axis controls senescence bypass and BCL-XL dependence in vincristine-resistant rhabdomyosarcoma (Ignatius)
November 5, 2026Yadong Wang1 ∙ Andrea D. Largent1 ∙ Dorothy Lee1 ∙ Paulomi Modi2 ∙ Long Wang2 ∙ Anshu Bandhlish1 ∙ Myron Ignatius2 ∙ Eleanor Y. Chen1,3 Highlights MAPK pathway activation in vincristine-resistant fusion-negative rhabdomyosarcoma MEK inhibition induces …
Cells: Trichostatin A Modulates Ethanol Consumption and Reveals Dose- and Sex-Specific Transcriptomic Signatures in the Nucleus Accumbens Shell (Lai)
November 5, 2026Yi Zou 1, , Sheketha R. Hauser 2,3, Teresa J. Raba 4, Richard L. Bell 2,3, Zhao Lai 1,5 Tiebing Liang 4,* Abstract Background: Histone deacetylase inhibitors (HDACis) such as Trichostatin A (TSA) have emerged as promising epigenetic modulators of addic …
Nucleic Acids Research: PCNA–RECQL5–RPRD1B recruit repair components to stressed replication forks to promote survival of BRCA1-deficient cancer cells (Sung, Olsen)
November 4, 2026Manh Tien Tran Elizabeth A Williamson Aruna S Jaiswal Dominic Arris Nhat Nguyen Andrew Carrillo Shaun Olsen Kimi Kong Montasser Shaheen Doraid Sadadeen Daohong Zhou Yaxia Yuan Shahrez Syed Youngho Kwon Sameer Salunkhe Patrick Sung Robert Hromas Abstrac …
Congrats DOCTOR Erich Sohn!!
November 2, 2026We are excited to announce that Erich Sohn has successfully defended his PhD thesis! Congratulations to Erich and his mentor, Dr. David Libich, on this outstanding achievement. This milestone reflects years of dedication, hard work, and meaningful scie …
Science Advances: Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors (Zheng, Ignatius)
November 2, 2026Funan He, Mehwish Noureen, Eloise Dray, Myron S. Ignatius, Xiaojing Wang, and Siyuan Zheng Abstract Whole-genome doubling (WGD) occurs frequently in human cancer and influences tumor evolution, metastasis, and treatment response. Here, we integrate bu …
Springer Nature: The1H, 15N and13C backbone resonance assignments of an intrinsically disordered region (124–270) of BRCA1 associated RING domain 1 (BARD1) (Sung & Libich Labs)
October 30, 2026Hoang H. Dinh, Angela M. Jasper, Antoine Baudin, Patrick Sung & David S. Libich Abstract The BRCA1-associated RING domain protein 1 (BARD1) is the obligate binding partner of the tumor suppressor breast cancer type 1 susceptibility protein (BRCA1) …
Application Window Now Open for the 2027 Greehey CCRI Summer Research Program!
October 26, 2026The Greehey Children’s Cancer Research Institute (Greehey CCRI) Donald G. McEwen Memorial Summer Research Program is now accepting applications for its 2027 summer cohort. Students interested in gaining hands-on research experience in childhood cancer …
Nature Reviews – Molecular Cell Biology: Mechanisms and Disease Relevance of DNA Break Repair Pathway Choice (Sung Lab)
October 21, 2026Michelle L. Swift, Cody M. Rogers, Hardeep Kaur, Dipanjan Chowdhury & Patrick Sung Abstract Understanding what drives the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) as the DNA double-strand break (DSB) repair …
Nature Communications: Saturation mutagenesis enables RAD51D clinical variant interpretation and identifies distinct biochemical functions (Sung/Olsen)
October 6, 2026Kristie E. Darrah, Shelby L. Hemker, Yashpal Rawal, Noah J. Goff, Phoebe S. Parker, Gayatri S. Ganesan, Caleb M. Stratton, Katherine G. Oppenheimer, Ella Roberts, Elena Glick, Nicole Banks, Arjun K. Kumar, Silvia Casadei, Matthew W. Snyder, Kara J. Mil …
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