Cell: Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation (Gupta Lab)
January 17, 2025Giuseppe Quarto1,12 ∙ Andrea Li Greci1,12 ∙ Martin Bizet1,12 ∙ Audrey Penning1 ∙ Irina Primac1 ∙ Frédéric Murisier1 ∙ Liliana Garcia-Martinez2 ∙ Rodrigo L. Borges2 ∙ Qingzeng Gao3,4 ∙ Pradeep K.R. Cingaram2 ∙ Emilie Calonne1 ∙ Bouchra Hassabi1 ∙ Céline …
International Journal of Molecular Sciences: Targeting Metabolic and Epigenetic Vulnerabilities in Glioblastoma with SN-38 and Rabusertib Combination Therapy (Penalva)
January 16, 2025Jennifer Chiou Valeria Impedovo Yen Bao Huynh ,Ruggiero Gorgoglione Luiz O. F. Penalva Alessia Lodi Andrew J. Brenner Stefano Tiziani Abstract Glioblastoma (GBM), the most prevalent primary malignant brain tumor, remains challenging to treat due to ext …
Luiz Penalva, PhD, to Receive “The Cure Starts Here” Grant.
January 7, 2025Lay Abstract Medulloblastoma (MB) is the most common malignant brain tumor in children. Treatment has improved survival in recent years, but patients are frequently left with devastating neurocognitive sequelae. Patients in molecular subgroups 3 and 4 …
Aging Cell: Age-Dependent Bi-Phasic Dynamics of Ly49+CD8+ Regulatory T Cell Population (Rao)
December 19, 2024Saranya Srinivasan, Shruti Mishra, Kenneth Ka-Ho Fan, Liwen Wang, John Im, Courtney Segura, Neelam Mukherjee, Gang Huang, Manjeet Rao, Chaoyu Ma, Nu Zhang ABSTRACT Aging is tightly associated with reduced immune protection but increased risk of autoimm …
Greehey CCRI Deputy Director, Manjeet Rao, PhD, to receive $100K”The Cure Starts Now” Grant.
December 5, 2024Our study has the potential to provide potent and safe alternatives for treating pediatric brain tumor patients. In addition, the drugs identified in our study will improve the efficacy of radiation therapy. Therefore, medulloblastoma pat …
Clinical Cancer Research: Update on Surveillance for Wilms Tumor and Hepatoblastoma in Beckwith–Wiedemann Syndrome and Other Predisposition Syndromes (Tomlinson)
December 2, 2024Update on Surveillance for Wilms Tumor and Hepatoblastoma in Beckwith–Wiedemann Syndrome and Other Predisposition Syndromes Jennifer M. Kalish Kerri D. Becktell Gaëlle Bougeard Garrett M. Brodeur Lisa R. Diller Andrea S. Doria Jordan R. Hansford Steven …
SLAS Discovery: The History, Landscape, and Outlook of Human Cell Line Authentication and Security (Pertsemlidis)
November 20, 2024Elijah Harbut1,2,3 ∙ Yiorgos Makris4 ∙ Alexander Pertsemlidis5,6,7 ∙ Leonidas Bleris1,2,3 1 Introduction The phenomenon of cellular cross-contamination and misidentification (“CCCM”) was identified more than six decades ago and continues to pose signif …
Molecular Cancer Therapeutics: Abstract B016: RNA demethylase ALKBH5 drives medulloblastoma growth and progression (Rao, Chen, Gupta, & Houghton Labs)
November 18, 2024Panneerdoss Subbarayalu; Daisy Medina; Pitta Prabhakar; Shahad Abdulsahib; Saif Nirzhor; Desiree Denman; Santosh Timilsina; Deepika Singh; Phat Do; Krishna Evani; Dhiya Billa; Esha Reddy; Peter Houghton; Yogesh Gupta; Yidong Chen; Suryavathi Viswanadha …
Pharmacology & Therapeutics: Lessons learned from 20 years of preclinical testing in pediatric cancers (Houghton, Kurmasheva)
November 11, 2024Malcolm A. Smith a, Peter J. Houghton b, Richard B. Lock c, John M. Maris d, Richard Gorlick e, Raushan T. Kurmasheva b, Xiao-Nan Li f, Beverly A. Teicher a, Jeffrey H. Chuang g, Filemon S. Dela Cruz h, Michael A. Dyer i, Andrew L. Kung h, Michael W. L …
Molecular Oncology: Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma (Libich Lab)
October 3, 2024Erich J. Sohn, David S. Libich Abstract Ewing sarcoma, an aggressive pediatric cancer, is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF chromatin remodeling complex. Central to this mechanism is the formati …
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