Greehey CCRI Archives
Biochemistry: Confinement and Stabilization of Fyn SH3 Folding Intermediate Mimetics within the Cavity of the Chaperonin GroEL Demonstrated by Relaxation-Based NMR
February 21, 2017David S Libich 1, Vitali Tugarinov 1, Rodolfo Ghirlando 1, G Marius Clore 1 Abstract The interaction of two folding intermediate mimetics of the model protein substrate Fyn SH3 with the chaperonin GroEL, a supramolecular foldase/unfoldase machine, has …
Journal of Clinical Oncology: Successful integration of genetic counseling in a comprehensive childhood cancer survivorship clinic.
February 10, 2017Shafqat Shah, Gregory John Aune, Lindsey Mette, Natalie Poullard Background: Awareness of inherited genetic risk and cancer predisposition has markedly increased. Research has shown that germline mutations in known cancer predisposition genes are ident …
Bioinformatics: Riborex: fast and flexible identification of differential translation from Ribo-seq data
January 31, 2017Authors Wenzheng Li, Weili Wang, Philip J Uren, Luiz OF Penalva, Andrew D Smith Abstract Motivation Global analysis of translation regulation has recently been enabled by the development of Ribosome Profiling, or Ribo-seq, technology. This approach pro …
Pediatric Hematology Oncology: Paraneoplastic Galactorrhea in Childhood T-ALL: An Evaluation of Tumor-derived Prolactin
January 1, 2017Allison Grimes 1, Nooshin Mirkheshti, Bandana Chatterjee, Gail Tomlinson, Chatchawin Assanasen Abstract T-cell acute lymphoblastic leukemia (T-ALL) comprises 15% of childhood leukemia. Although multiagent pulse chemotherapy has improved event-free surv …
Washington Post: A new urgency to protect survivors of childhood cancer
December 25, 2016SAN ANTONIO — When Brittany Galan was diagnosed with leukemia at 6 weeks old, doctors warned her parents she had little chance of surviving — she was so young and so sick. But after being treated with chemotherapy, “I lived and lived!” said the exubera …
Developmental Cell: CENP-A Ubiquitylation Is Required for CENP-A Deposition at the Centromere
December 20, 2016YoheiNiikura1, RisaKitagawa1, KatsumiKitagawa1 Main Text CENP-A is a centromere-specific histone variant that determines centromere identity, but how it localizes to centromeres is not completely understood. Previously, we demonstrated that CENP-A depo …
Ft. Worth Business: Cancer treatments that save children’s lives exact a heavy price years later
December 16, 2016The lifesaving chemo, however, took a heavy toll. It “messed me up neurologically,” Galan said. In grade school, she had trouble with reading and math and eventually went on ADHD medication. In college, the once-avid runner developed a heart problem. R …
IEEE Xplore: Analyzing Differential Regulatory Networks Modulated by Continuous-State Genomic Features in Glioblastoma Multiforme
December 5, 2016Yu-Chiao Chiu; Tzu-Hung Hsiao; Li-Ju Wang; Yidong Chen; Eric Y. Chuang Abstract: Gene regulatory networks are a global representation of complex interactions between molecules that dictate cellular behavior. The study of a regulatory network modulated …
Genome Biology: Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma
December 1, 2016Bruna R Correa, Patricia Rosa de Araujo, Mei Qiao, Suzanne C Burns, Chen Chen, Richard Schlegel, Seema Agarwal, Pedro AF Galante, Luiz OF Penalva Background Glioblastoma (GBM) is the most common and aggressive type of brain tumor. Currently, GBM has an …
Molecular Cancer Therapeutics: Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis
December 1, 2016Alfeu Zanotto-Filho, V. Pragathi Masamsetti, Eva Loranc, Sonal S. Tonapi, Aparna Gorthi, Xavier Bernard, Rosângela Mayer Gonçalves, José C.F. Moreira, Yidong Chen and Alexander J.R. Bishop Abstract Alkylating agents are a commonly used cytotoxic class …