Greehey CCRI Archives
IEEE: Cancer Progression Prediction Using Gene Interaction Regularized Elastic Net.
December 23, 2015Lin Zhang; Hui Liu; Yufei Huang; Xuesong Wang; Yidong Chen; Jia Meng Abstract: Different types of genomic aberration may simultaneously contribute to tumorigenesis. To obtain a more accurate prognostic assessment to guide therapeutic regimen choice for …
Cure Today: The Circle of Life: Saving Fertility After Cancer
December 21, 2015Cancer survivors have more options to save their fertility.
Molecular Cancer Research: Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor
December 1, 2015Amelie Forest 1, Michael Amatulli 1, Dale L Ludwig 1, Christopher B Damoci 1, Ying Wang 1, Colleen A Burns 1, Gregory P Donoho 2, Nina Zanella 3, Heinz H Fiebig 3, Marie C Prewett 1, David Surguladze 1, James T DeLigio 1, Peter J Houghton 4, Malcolm A …
Genes & Cancer: The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma
November 7, 2015David J. Elzi1, Meihua Song1, Peter J. Houghton1,2,3, Yidong Chen1,2,4, and Yuzuru Shiio1,2,5 ABSTRACT Ewing sarcoma is a cancer of the bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets famil …
Business Wire: Epizyme to Present New Scientific Data on the Role of HMT Inhibitors in Cancer
November 4, 2015CAMBRIDGE, Mass.–(BUSINESS WIRE)–Epizyme, Inc. (NASDAQ: EPZM), a clinical-stage biopharmaceutical company creating novel epigenetic therapies for cancer patients, will present data from 11 accepted abstracts on the role of histone methyltransferase ( …
Asian Pacific Journal of Cancer Prevention: Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia
November 1, 2015Duangjai Piwkham 1, Teerapong Siriboonpiputtana, Joke Beuten, Samart Pakakasama, Jonathan Al Gelfond, Karan Paisooksantivatana, Gail E Tomlinson, Budsaba Rerkamnuaychoke Abstract Background: Folylpolyglutamate synthetase (FPGS), an important enzyme in …
PNAS: Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain
November 1, 2015Gangadhara R. Sareddy, Quanguang Zhang, Ruimin Wang, Erin Scott, Yi Zou, Jason C. O’Connor, Yidong Chen, Yan Dong, Ratna K. Vadlamudi, and Darrell Brann Abstract 17-β estradiol (E2) has been implicated as neuroprotective in a variety of neurodegenerati …
Oncotarget: An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype
October 23, 2015Ming-Kai Chuang1,*, Yu-Chiao Chiu2,5,*, Wen-Chien Chou1,3, Hsin-An Hou3, Mei-Hsuan Tseng3, Yi-Yi Kuo1,3, Yidong Chen5,6, Eric Y. Chuang2,4, Hwei-Fang Tien3 ABSTRACT Although clinical features, cytogenetics, and mutations are widely used to predict prog …
ASCI Post: Children’s Hospital of Philadelphia Is a Founding Member of the New Pediatric Preclinical Testing Consortium (Houghton mention)
October 10, 2015Addressing the relatively small number of new cancer drugs for children, a selective group of leading research centers is joining a new federally funded research consortium aimed at bringing scientific rigor and a concentrated effort to identifying new …
Pediatric Blood & Cancer: Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma
October 1, 2015Adam Studebaker 1, Kathryn Bondra 2, Star Seum 2, Changxian Shen 1, Doris A Phelps 1, Christopher Chronowski 2, Justin Leasure 2, Paul D Smith 3, Raushan T Kurmasheva 1, Xiaokui Mo 4, Maryam Fouladi 5, Peter J Houghton 1 Abstract Purpose: Curative ther …