Greehey CCRI Archives
RNA Biology: Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells
November 18, 2018Caihong Yi,Guiming Li,Dmitri N. Ivanov,Zhonghua Wang,Mitzli X. Velasco,Greco Hernández,Soni Kaundal,Johanna Villarreal,Yogesh K. Gupta ,Mei Qiao,Christopher G. Hubert,Matthew J. Hart &Luiz O.F. Penalva ABSTRACT RNA binding proteins have emerged as …
RNA Biology: Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells
November 2, 2018Caihong Yi, Guiming Li, Dmitri N Ivanov, Zhonghua Wang, Mitzli X Velasco, Greco Hernández, Soni Kaundal, Johanna Villarreal, Yogesh K Gupta, Mei Qiao, Christopher G Hubert, Matthew J Hart, Luiz OF Penalva RNA binding proteins have emerged as critical o …
Oncotarget: Increased expression of the thyroid hormone nuclear receptor TRα1 characterizes intestinal tumors with high Wnt activity
July 24, 2018Joel Uchuya-Castillo, Nicolas Aznar, Carla Frau, Pierre Martinez, Clementine Le Nevé, Laetitia Marisa, Luiz OF Penalva, Pierre Laurent-Puig, Alain Puisieux, Jean-Yves Scoazec, Jacques Samarut, Stephane Ansieau, Michelina Plateroti Our previous work dem …
Scientific Reports: Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity
March 6, 2018Bruna RS Correa, Joanna Hu, Luiz OF Penalva, Richard Schlegel, David L Rimm, Pedro AF Galante, Seema Agarwal Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug tar …
BMC Cancer: MicroRNA-195 acts as an anti-proliferative miRNA in human melanoma cells by targeting Prohibitin 1
December 1, 2017Priscila Daniele Ramos Cirilo, Luciana Nogueira de Sousa Andrade, Bruna Renata Silva Corrêa, Mei Qiao, Tatiane Katsue Furuya, Roger Chammas, Luiz Otavio Ferraz Penalva Background Melanoma is the most lethal type of skin cancer. Since chemoresistance is …
Genome Biology: The 3′ end of the story: deciphering combinatorial interactions that control mRNA fate.
November 29, 2017Authors Penalva LOF Sanford JR Precise control of messenger RNA (mRNA) fate—its translation, stability, and localization—is required for accurate eukaryotic gene expression and is of fundamental importance to human health and disease. Initial efforts t …
Human Genetics: RNA processing as an alternative route to attack glioblastoma
September 1, 2017Fabiana Marcelino Meliso, Christopher G Hubert, Pedro A Favoretto Galante, Luiz O Penalva Genomic analyses have become an important tool to identify new avenues for therapy. This is especially true for cancer types with extremely poor outcomes since ou …
Human Genetics: From mechanisms to therapy: RNA processing’s impact on human genetics
September 1, 2017Authors Luiz O Penalva, Jeremy R Sanford Protein-coding genes defy the one gene-one enzyme paradigm, in part, through the process of alternative pre-mRNA splicing. This mode of gene regulation is critical for generating protein isoforms with specific f …
Bioinformatics: Riborex: fast and flexible identification of differential translation from Ribo-seq data
January 31, 2017Authors Wenzheng Li, Weili Wang, Philip J Uren, Luiz OF Penalva, Andrew D Smith Abstract Motivation Global analysis of translation regulation has recently been enabled by the development of Ribosome Profiling, or Ribo-seq, technology. This approach pro …
Genome Biology: Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma
December 1, 2016Bruna R Correa, Patricia Rosa de Araujo, Mei Qiao, Suzanne C Burns, Chen Chen, Richard Schlegel, Seema Agarwal, Pedro AF Galante, Luiz OF Penalva Background Glioblastoma (GBM) is the most common and aggressive type of brain tumor. Currently, GBM has an …