Greehey CCRI Archives
Cancer Research: SNAI2-mediated repression of BIM protects rhabdomyosarcoma from ionizing radiation (Houghton, Ignatius, & Zheng Labs)
August 31, 2021Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. C …
Pediatric Blood & Cancer: In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC) (Kurmasheva, Houghton)
August 30, 2021Raushan T. Kurmasheva, Stephen W. Erickson, Ruolan Han, Beverly A. Teicher, Malcolm A. Smith, Michael Roth, Richard Gorlick, Peter J. Houghton Abstract SP-2577(Seclidemstat), an inhibitor of lysine-specific demthylase KDM1A (LSD1) that is overexpressed …
Science Advances: Predicting and characterizing a cancer dependency map of tumors with deep learning (Aune, Chen, Rao, Houghton & Zheng Labs)
August 24, 2021Yu-Chiao Chiu1, Siyuan Zheng1,2, Li-Ju Wang1, View ORCID ProfileBrian S. Iskra1, View ORCID ProfileManjeet K. Rao1,3, Peter J. Houghton1,4, View ORCID ProfileYufei Huang5,6,* and View ORCID ProfileYidong Chen1,2,* Abstract Genome-wide loss-of-function …
Drs Houghton and Kurmasheva to Receive 5-year, $2.9M NCI Pediatric In Vivo Testing Program (PIVOT) U01 Grant Renewal
August 10, 2021NCI Pediatric In Vivo Testing Program (U01), renewal for the previous PPTC (Pediatric Preclinical Testing Consortium). Grant period: July 2021-June 2026. Total dollar amount: $2,900,000 over 5 years. Abstract Cancer in children is rare with …
Neuro-Oncololgy Advances: The effects of palbociclib in combination with radiation in preclinical models of aggressive meningioma (Houghton)
August 4, 2021Craig Horbinski, Guifa Xi, Yufen Wang, Rintaro Hashizume, Mahesh Gopalakrishnan, Joanna J Phillips, Peter Houghton, Charles D James, John A Kalapurakal Abstract Background Meningiomas are the most common tumor arising within the cranium of adults. Desp …
Cell Reports: NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growthNELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth (Shiio, Houghton)
July 8, 2021Panneerselvam Jayabal1, Fuchun Zhou1, Xiufen Lei1, XiuyeMa1, Barron Blackman1, Susan T.Weintraub23, Peter J.Houghton134, YuzuruShiio1235 Highlights • The autocrine signaling mediated by NELL2 maintains Ewing sarcoma cell growth • NELL2 signaling inhibi …
Dr. Houghton Co-Authors MDPI paper, “Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells
July 2, 2021Authored by: Jun Luo, Yoshinobu Odaka, Zhu Huang, Bing Cheng, Wang Liu, Lin Li, Chaowei Shang, Chao Zhang, Yang Wu, Yan Luo, Shengyong Yang, Peter J. Houghton, Xiaofeng Guo, Shile Huang Abstract Dihydroartemisinin (DHA), an anti-malarial drug, has been …
Angelina Vaseva, PhD Presented 2021 Voelcker Pilot Award (Houghton Lab)
June 16, 2021Angelina Vaseva, PhD Congratulations to Angelina Vaseva, PhD, research assistant professor at Greehey Children’s Cancer Research Institute and the Department of Molecular Medicine, on being presented a 2021 2021 Voelcker Pilot Award. Dr. Vaseva’s proje …
Please welcome the Greehey CCRI summer 2021 interns
June 7, 2021*not all summer program students pictured Greehey CCRI would like to welcome the 2021 Donald G McEwen, Memorial Summer Undergraduate Research Program students. Gaby Ruban – Dr. Chen …
Molecular Cancer Therapeutics: International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer (Houghton)
June 4, 2021Gilles Vassal, Peter J Houghton, Stefan M Pfister, Malcolm A. Smith, Huib N Caron, Xiao-Nan Li, David J Shields, Olaf Witt, Jan J Molenaar, Sara Colombetti, Julia Schuler, and Lou F Stancato Abstract Cancer remains the leading cause of disease-related …