Greehey CCRI Archives
Dr. Zhao Lai to Receive NCI R50 Funding
August 24, 2022The National Cancer Institute (NCI) has recently awarded an R50 Research Specialist Award to Dr. Zhao Lai, Associate Professor/Research, Director of the Next-Generation Sequencing Shared Resource (NGSSR) in the NCI-designated Mays Cancer Center (MCC). …
International Journal of Molecular Sciences: Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist (Lai)
July 12, 2022Yi He 1,2, Salvador Alejo 1, Prabhakar Pitta Venkata 1, Jessica D. Johnson 1, Ilanna Loeffel 1, Uday P. Pratap 1, Yi Zou 3, Zhao Lai 3, Rajeshwar R. Tekmal 1,4, Edward R. Kost 1 and Gangadhara R. Sareddy 1,4,* Abstract Ovarian cancer (OCa) is the dead …
International Journal of Cancer: Integrin alpha 6 (ITGA6) is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex (Lai, Chen)
June 6, 2022Integrin alpha 6 (ITGA6) is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex Guixi Zheng,Hakim Bouamar,Matyas Cserhati,Carla R. Zeballos,Isha Mehta,Habil Zare,Larry Broome,Ruolei Hu,Zhao Lai,Yidong Chen,Francis …
Molecular Carcinogenesis: SIRT1 inhibition-induced senescence as a strategy to prevent prostate cancer progression (Chen, Lai)
April 25, 2022Abstract Emerging evidence suggests an important role for SIRT1, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase in cancer development, progression, and therapeutic resistance; making it a viable therapeutic target. Here, we examined th …
BMC: SETDB1 interactions with PELP1 contributes to breast cancer endocrine therapy resistance (Lai, Chen, Rao)
April 11, 2022Zexuan Liu, Junhao Liu, Behnam Ebrahimi, Uday P. Pratap, Yi He, Kristin A. Altwegg, Weiwei Tang, Xiaonan Li, Zhao Lai, Yidong Chen, Liangfang Shen, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Rajeshwar R. Tekmal, Manjeet K. Rao & Ratna K. Va …
Cell Death & Disease: Global profiling reveals common and distinct N6-methyladenosine (m6A) regulation of innate immune responses during bacterial and viral infections (Lai & Chen Labs)
March 15, 2022Jian Feng, Teng Zhang, Océane Sorel, Wen Meng, Xinquan Zhang, Zhao Lai, Weiming Yuan, Yidong Chen, Yufei Huang & Shou-Jiang Gao Abstract N6-methyladenosine (m6A) is a dynamic post-transcriptional RNA modification influencing all aspects of mRNA bio …
Cancers: Global Genomic and Proteomic Analysis Identified Critical Pathways Modulated by Proto-Oncogene PELP1 in TNBC (Chen & Lai)
February 25, 2022by Zexuan Liu 1,2,†,Kristin A. Altwegg 1,3,†ORCID,Junhao Liu 1,2,Susan T. Weintraub 4,Yidong Chen 5,6,Zhao Lai 5,7,Gangadhara R. Sareddy 1,3,Suryavathi Viswanadhapalli 1,3,*ORCID and Ratna K. Vadlamudi 1,3,8,* Simple Summary The proto-oncogene PELP1 is …
Brain, Behavior, & Immunity: Sex-dependent pain trajectories induced by prolactin require an inflammatory response for pain resolution (Lai Lab)
January 24, 2022Author links open overlay panelJenniferMecklenburga AndiWangzhouf Anahit H.Hovhannisyana PriscillaBarba-Escobedoa Sergey A.Sheinb YiZoud KorriWeldond ZhaoLaideVincentGoffing GregoryDussorf Alexei V.Tumanovb Theodore J.Pricef Armen N.Akopiana …
Frontiers in Microbiology: Robust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor (Lai Lab)
January 20, 2022Yehong Huang1,2†, Wurihan Wurihan2†, Bin Lu1,2†, Yi Zou3, Yuxuan Wang2†, Korri Weldon3, Joseph D. Fondell2†, Zhao Lai3,4, Xiang Wu1*†, and Huizhou Fan2*† Cells reprogram their transcriptome in response to stress, such as heat shock. In free-living bact …
Frontiers in Genetics: Differential lncRNA/mRNA Expression Profiling and Functional Network Analyses in Bmp2 Deletion of Mouse Dental Papilla Cells (Lai Lab)
January 20, 2022Feng Wang1,2†, Ran Tao1†, Li Zhao1, Xin-Hui Hao1, Yi Zou3, Qing Lin1, Meng Meng Liu2, Graham Goldman2, Daoshu Luo1* and Shuo Chen2* Bmp2 is essential for dentin development and formation. Bmp2 conditional knock-out (KO) mice display a similar tooth phe …