Greehey CCRI Archives
BMC Med Informatics & Decision Making: On the Role of Deep Learning Model Complexity in Adversarial Robustness for Medical Images (Chen Lab)
June 21, 2022David Rodriguez, Tapsya Nayak, Yidong Chen, Ram Krishnan & Yufei Huang Abstract Deep learning (DL) models are highly vulnerable to adversarial attacks for medical image classification. An adversary could modify the input data in imperceptible ways …
American Journal of Heart & Circulatory Physiology: Development and Characterization of a Mass Cytometry Panel for Detecting the Effect of Acute Doxorubicin Exposure on Murine Cardiac Non-myocytes (Bishop, Chen, & Aune Labs)
June 8, 2022Brian S. Iskra, Logan R. Davis, Henry E. Miller, Yu-Chiao Chiu, Alexander J.R. Bishop, Yidong Chen, and Gregory J. Aune Abstract Childhood cancer survivors (CCSs) face lifelong side effects related to their treatment with chemotherapy. Anthracycline ag …
International Journal of Cancer: Integrin alpha 6 (ITGA6) is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex (Lai, Chen)
June 6, 2022Integrin alpha 6 (ITGA6) is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex Guixi Zheng,Hakim Bouamar,Matyas Cserhati,Carla R. Zeballos,Isha Mehta,Habil Zare,Larry Broome,Ruolei Hu,Zhao Lai,Yidong Chen,Francis …
Cancer Letters: The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events (Rao & Chen Labs)
May 18, 2022Santosh Timilsinaab1 Subapriya Rajamanickambc1 Arhan Raoh Panneerdoss Subbarayaluab Saif Nirzhorab Nourhan Abdelfattahi Suryavathi Viswanadhapallie Yidong Chenbd IsmailJatoif Andrew Brennerg Manjeet K.Raoab Ratna Vadlamudie Virginia Kaklamanig Highligh …
Molecular Carcinogenesis: SIRT1 inhibition-induced senescence as a strategy to prevent prostate cancer progression (Chen, Lai)
April 25, 2022Abstract Emerging evidence suggests an important role for SIRT1, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase in cancer development, progression, and therapeutic resistance; making it a viable therapeutic target. Here, we examined th …
BMC: SETDB1 interactions with PELP1 contributes to breast cancer endocrine therapy resistance (Lai, Chen, Rao)
April 11, 2022Zexuan Liu, Junhao Liu, Behnam Ebrahimi, Uday P. Pratap, Yi He, Kristin A. Altwegg, Weiwei Tang, Xiaonan Li, Zhao Lai, Yidong Chen, Liangfang Shen, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Rajeshwar R. Tekmal, Manjeet K. Rao & Ratna K. Va …
Cancer Research: M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression (Gupta, Zheng, Houghton, Chen, and Rao Labs)
March 21, 2022Pooja Yadav; Panneerdoss Subbarayalu; Daisy Medina, Saif Nirzhor; Santosh Timilsina; Subapriya Rajamanickam; Vijay K. Eedunuri; Yogesh Gupta Siyuan Zheng Nourhan Abdelfattah Yufei Huang Ratna Vadlamudi Robert Hromas; Paul Meltzer Peter Houghton; Yidon …
Cell Death & Disease: Global profiling reveals common and distinct N6-methyladenosine (m6A) regulation of innate immune responses during bacterial and viral infections (Lai & Chen Labs)
March 15, 2022Jian Feng, Teng Zhang, Océane Sorel, Wen Meng, Xinquan Zhang, Zhao Lai, Weiming Yuan, Yidong Chen, Yufei Huang & Shou-Jiang Gao Abstract N6-methyladenosine (m6A) is a dynamic post-transcriptional RNA modification influencing all aspects of mRNA bio …
eLife: Signature-scoring methods developed for bulk samples are not adequate for cancer single-cell RNA sequencing data (Zheng, Chen, & Wang Labs)
March 7, 2022Nighat Noureen, Zhenqing Ye, Yidong Chen, Xiaojing Wang, Siyuan Zheng Abstract Quantifying the activity of gene expression signatures is common in analyses of single-cell RNA sequencing data. Methods originally developed for bulk samples are often …
Cancers: Global Genomic and Proteomic Analysis Identified Critical Pathways Modulated by Proto-Oncogene PELP1 in TNBC (Chen & Lai)
February 25, 2022by Zexuan Liu 1,2,†,Kristin A. Altwegg 1,3,†ORCID,Junhao Liu 1,2,Susan T. Weintraub 4,Yidong Chen 5,6,Zhao Lai 5,7,Gangadhara R. Sareddy 1,3,Suryavathi Viswanadhapalli 1,3,*ORCID and Ratna K. Vadlamudi 1,3,8,* Simple Summary The proto-oncogene PELP1 is …