Greehey CCRI Archives
Cellular Oncology: Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 down regulation in Ewing sarcoma cells (Houghton, Chen, Kitagawa, Ignatius)
January 12, 2022Roxane Khoogar, Fuyang Li, Yidong Chen, Myron Ignatius, Elizabeth R. Lawlor, Katsumi Kitagawa, Tim H.-M. Huang, Doris A. Phelps & Peter J. Houghton Background The EWSR1/FLI1 gene fusion is the most common rearrangement leading to cell transformatio …
Briefings in Bioinformatics: Deep learning tackles single-cell analysis—a survey of deep learning for scRNA-seq analysis (Chen Lab)
January 4, 2022Mario Flores, Zhentao Liu, Tinghe Zhang, Md Musaddaqui Hasib, Yu-Chiao Chiu, Zhenqing Ye, Karla Paniagua, Sumin Jo, Jianqiu Zhang, Shou-Jiang Gao, Yu-Fang Jin, Yidong Chen, Yufei Huang Abstract Since its selection as the met …
MSN: Using Next Generation Sequencing, the Greehey CCRI bioinformatics team is helping determine COVID19 strains (Chen, Lai, Zheng, Wang Labs)
December 17, 2021“Since the coronavirus pandemic began almost two years ago there have been over a dozen strains of the virus. Here at UT Health San Antonio, they have a lab which differentiates between each of the strains in an effort to save lives. UT Health San Anto …
Molecular Cancer Therapeutics: Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis and Tumor Regression in H/NRAS Q61X-mutant Rhabdomyosarcoma (Houghton, Chen, Ignatius, Vaseva)
November 8, 2021Natalia Garcia, Vanessa Del Pozo, Marielle E. Yohe, Craig M. Goodwin, Terry J Shackleford, Long Wang, Kunal Baxi, Yidong Chen, Anna T Rogojina, Sara M. Zimmerman, Cody J. Peer, William D. Figg, Myron S. Ignatius, Kris C Wood, Peter J. Houghton, and Ang …
Communications Biology: LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer (Chen)
November 1, 2021Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrahimi, Hui Yan, Yi Zou, Swapna Konda, Gangadhara R. Sareddy, Zhenming Xu, Yidong Chen, …
Molecular Cancer Research: GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer (Chen)
October 27, 2021Marieke Burleson, Janice J. Deng, Tai Qin, Thu Minh Duong, Yuqian Yan, Xiang Gu, Debodipta Das, Acarizia Easley, Michael A. Liss, P. Renee Yew, Roble Bedolla, Addanki Pratap Kumar, Tim Hui-Ming Huang, Yi Zou, Yidong Chen, Chun-Liang Chen, Haojie Huang, …
Science Advances: Predicting and characterizing a cancer dependency map of tumors with deep learning (Aune, Chen, Rao, Houghton & Zheng Labs)
August 24, 2021Yu-Chiao Chiu1, Siyuan Zheng1,2, Li-Ju Wang1, View ORCID ProfileBrian S. Iskra1, View ORCID ProfileManjeet K. Rao1,3, Peter J. Houghton1,4, View ORCID ProfileYufei Huang5,6,* and View ORCID ProfileYidong Chen1,2,* Abstract Genome-wide loss-of-function …
Aging Cell: Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury (Chen Lab)
June 12, 2021Hak Joo Lee, Andrew Donati, Denis Feliers, Yuyang Sun, Yanli Ding, Muniswamy Madesh, Adam B. Salmon, Yuji Ikeno, Corinna Ross, Christopher L. O’Connor, Wenjun Ju, Markus Bitzer, Yidong Chen, Goutam Ghosh Choudhury, Brij B. Singh, Kumar Sharma, Balakunt …
Please welcome the Greehey CCRI summer 2021 interns
June 7, 2021*not all summer program students pictured Greehey CCRI would like to welcome the 2021 Donald G McEwen, Memorial Summer Undergraduate Research Program students. Gaby Ruban – Dr. Chen …
BMC Bioinformatics: CancerSiamese: one-shot learning for predicting primary and metastatic tumor types unseen during model training (Chen Lab)
May 13, 2021Milad Mostavi, Yu-Chiao Chiu, Yidong Chen & Yufei Huang Abstract Background The state-of-the-art deep learning-based cancer type prediction can only predict cancer types whose samples are available during the training where the sample size is commo …