Nucleic Acids Research: TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells (Gupta, Pertsemlidis, Bishop, & Sung Labs)

Published On: November 20, 2023
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Aruna S Jaiswal, Arijit Dutta, Gayathri Srinivasan, Yaxia Yuan, Daohong Zhou, Montaser Shaheen, Doraid T Sadideen, Austin Kirby, Elizabeth A Williamson, Yogesh K Gupta, Shaun K Olsen, Mingjiang Xu, Eva Loranc, Pramiti Mukhopadhyay, Alexander Pertsemlidis, Alexander J R Bishop, Patrick Sung, Jac A Nickoloff, Robert Hromas Abstract BRCA1-deficient cells have increased IRE1 RNase, which degrades multiple microRNAs. Reconstituting expression of one of these, miR-4638–5p, resulted in synthetic lethality in BRCA1-deficient cancer cells. We found that miR-4638-5p represses [...] Read more

Clinical Cancer Research: Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma (Kurmasheva)

Published On: October 18, 2023
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Brian Mooney Gian Luca Negri Taras Shyp Alberto Delaidelli Hai-Feng Zhang Sandra E. Spencer Miko Amber K. Weiner Alexander B. Radaoui Rawan Shraim Michael M. Lizardo Christopher S. Hughes Amy Li Melanie Rouleau Wei Li Dimiter S. Dimitrov Raushan T. Kurmasheva Sharon J. Diskin John M. Maris Gregg B. Morin Poul H. Sorensen Abstract Purpose: [...] Read more

Molecular Cell: DICER Ribonuclease Removes Harmful R-Loops (Sung)

Published On: October 18, 2023
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Lola P. Camino 1 2 4, Arijit Dutta 3 4, Sonia Barroso 1 2, Carmen Pérez-Calero 1 2, Jeffrey N. Katz 3, María García-Rubio 1 2, Patrick Sung 3, Belén Gómez-González 1 2, Andrés Aguilera 1 2 5 Highlights •DICER RNase activity mediates R-loop processing in vitro and in cells •DICER binds R-loops readily but not DNA-RNA hybrids •DICER cleaves the RNA moiety of DNA-RNA hybrids within R-loop structures •DICER overexpression counteracts harmful nuclear DNA-RNA hybrids Summary R-loops, consisting of a DNA-RNA hybrid and a displaced DNA strand, threaten genome integrity. To counteract [...] Read more

UT Health San Antonio gears up to fight childhood cancer, thanks to Hyundai Hope on Wheels® grants

Published On: September 26, 2023
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Posted on September 26, 2023 at 10:40 am.Shared by Eileen Teves Contacts: Monica Taylor, 210-450-8970, taylorm1@uthscsa.edu, Eileen Teves, 210-450-7239, tevese@uthscsa.edu SAN ANTONIO – Children with cancer were joined by their families as they dipped their hands in finger paint and left their mark on a new Hyundai SUV at The University of Texas Health Science [...] Read more

Open Access Government: Developing novel therapies for childhood cancers (Houghton)

Published On: September 19, 2023
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Dr Peter J Houghton from Greehey Children’s Cancer Research Institute discusses the obstacles in developing new treatments for childhood cancers and new approaches in preclinical testing. In my previous article for Open Access Government, I focused on the challenges of developing novel therapies for children with glioma, the most prevalent brain cancer in children. Here, [...] Read more

Cancers: Dysregulation of Type I Interferon (IFN-I) Signaling: A Potential Contributor to Racial Disparity in Hepatocellular Carcinoma (HCC) (Lai)

Published On: September 12, 2023
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            Saranya Chidambaranathan Reghupaty 1,†,Sadia Kanwal 2, Rachel G. Mendoza 3, Eva Davis 4,Haiwen Li 2, Zhao Lai 5, Mikhail G. Dozmorov 6 ,Milton Omar Faison 7, Rafat Ali Siddiqui 2, *Devanand Sarkar 8,* Simple Summary Hepatocellular carcinoma (HCC) is the most common primary liver cancer arising from the liver [...] Read more

Texas Public Radio: “Fighting childhood cancer in San Antonio” (Aune)

Published On: September 8, 2023
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September is Childhood Cancer Awareness Month, a time to raise awareness of this devastating disease and to support the children and families who are affected by it. Childhood cancer is the leading cause of death by disease for children under the age of 14. Each year, about 15,000 children in the United States are diagnosed [...] Read more

Embro Reports: Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping (Chen)

Published On: September 5, 2023
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Abstract Bromodomain-containing protein 4 (BRD4) is overexpressed and functionally implicated in various myeloid malignancies. However, the role of BRD4 in normal hematopoiesis remains largely unknown. Here, utilizing an inducible Brd4 knockout mouse model, we find that deletion of Brd4 (Brd4Δ/Δ) in the hematopoietic system impairs hematopoietic stem cell (HSC) self-renewal and differentiation, which associates with cell cycle arrest and [...] Read more

Allison Grimes, M.D., MSCI, Awarded $999K CPRIT Grant to Study “Expansion of HPV Vaccination Among Survivors of Childhood Cancer”

Published On: August 24, 2023
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Lay Summary Human papillomavirus (HPV) is known to cause most cervical, anal, and oropharyngeal cancers, and a large proportion of vaginal, vulvar, and penile malignancies. Every year nearly 39,000 new cases of HPV-related cancers are diagnosed in the United States alone. This incidence has persisted for nearly a decade following the launch of the HPV [...] Read more

Science Reports: Sex-dependent differences in the genomic profile of lingual sensory neurons in naïve and tongue-tumor bearing mice (Chen, Lai)

Published On: August 14, 2023
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Tarek Ibrahim, Ping Wu, Li-Ju Wang, Chang Fang-Mei, Josue Murillo, Jaclyn Merlo, Sergey S. Shein, Alexei V. Tumanov, Zhao Lai, Korri Weldon, Yidong Chen & Shivani Ruparel Abstract Mechanisms of sex-dependent orofacial pain are widely understudied. A significant gap in knowledge exists about the comprehensive regulation of tissue-specific trigeminal sensory neurons in diseased states of both [...] Read more