Search Results for "advanced"

Advanced Science: Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis (Bishop)

Published On: April 26, 2023
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Mingli Li, Lu Yang, Anthony K. N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen-Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J. R. Bishop, Chun-Wei Chen … See fewer authors  First published: 19 April 2023   Abstract Epigenetic dysregulation is reported in multiple cancers, including Ewing sarcoma (EwS). However, [...] Read more

Yogesh Gupta,PhD., Invited to Present at Advanced Photon Source of Argonne National Laboratory, COVID-19 Workshop

Published On: May 13, 2021
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Recently, Greehey CCRI principal investigator, Yogesh Gupta, PhD., was included as an invited speaker with prominent scientists from academia (Ian Wilson, Pamela Bjorkman, and others) and industry (Pfizer and Moderna) at a COVID-19 workshop organized by the Advanced Photon Source of Argonne National Laboratory, Chicago. Broadly, the workshop presented areas where structural biology research, including […]

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Advanced Photon Source: How SARS-CoV-2 RNA Evades Host Immune Responses (Gupta Lab)

Published On: August 26, 2020
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As we all know too well, the virus SARS-CoV-2 causes severe respiratory illness COVID-19. In parallel with the critical search for a cure, scientists are working diligently to develop effective treatments that can help lower the morbidity of this deadly virus. To develop these therapeutics, we must understand how the virus is able to invade […]

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Owens Foundation: Hypoxis-Derived Treatment for Advanced Lung Cancer

Published On: June 30, 2019
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Funding Agency: William and Ella Owens Medical Research Foundation Title: Hypoxis-derived treatment for advanced lung cancer Status: Active Period: 12/01/2015-11/30/2021 Role: Co-Investigator Grant Detail: To identify the molecular mechanisms of action of rooperol in lung cancer cell lines, design and synthesize analogs and pro-drugs to improve its biological properties, and evaluate analogs to identify potential lead clinical candidate

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Patterns: shinyDeepDR: A user-friendly R Shiny app for predicting anti-cancer drug response using deep learning (Chen lab, et al)

Published On: February 20, 2024
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Li-Ju Wang 1, Michael Ning 1, Tapsya Nayak 2, Michael J. Kasper 1, Satdarshan P. Monga 3 4 5, Yufei Huang 5 6 7 8, Yidong Chen 2 9, Yu-Chiao Chiu 1 4 5 10 Show more Highlights shinyDeepDR is a web tool for predicting responses to 265 anti-cancer compounds It is applicable for researching both cancer cell lines and tumors Its interactive web interface facilitates result interpretation and investigation It identifies promising targets for an “undruggable” mutation in liver cancer The bigger picture Understanding how different [...] Read more

In Memoriam: Sharon B. Murphy, MD (1943–2023)

Published On: December 15, 2023
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We share with great sadness that the inaugural director of the Greehey Children's Cancer Research Institute has passed.  Below is the obituary originally published in the American Society of Pediatric Hematology/Oncology on November 18, 2023.  She will always be remembered by those of us who were fortunate enough to work with her. It is an [...] Read more

Research Project C: Signaling Pathways in Childhood Sarcoma

Published On: March 16, 2023
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Program Goals Approximately 70% of children with sarcoma can be cured using multimodality treatments, but the outcome is still poor for those with advanced or metastatic disease. Specifically, the 5-year event-free survival rates are 30 percent or less in children with advanced or metastatic Ewing sarcoma, osteosarcoma, or rhabdomyosarcoma, and intensive chemo-radiotherapy has not substantially [...] Read more

Project B: The Pediatric In Vivo Testing Program (PIVOT)

Published On: March 16, 2023
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The development of new therapies for children with cancer presents unique challenges. Firstly, the incidence of cancer in children is relatively low; in the United States, about 12,400 new cases are diagnosed annually in patients under 20 years old. Each year in Texas, almost 1,200 children and adolescents younger than 20 years of age are [...] Read more

Cancer Research: Sequential Targeting of Retinoblastoma and DNA Synthesis Pathways Is a Therapeutic Strategy for Sarcomas That Can Be Monitored in Real Time (Houghton)

Published On: March 15, 2023
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Tuyen Duong;Thanh Nguyen; Yan Wang;  Tuyen N. Bui; Rossana Lazcano;  Davis R. Ingram;  Min Yi; Varshini Vakulabharanam; Linjie Luo; Marc A. Pina; Cansu Karakas ; Mi Li; Nicole M. Kettner; Neeta Somaiah; Peter J. Hougton; Osama Mawlawi; Alexander J. Lazar; Kelly K. Hunt; Khandan Keyomarsi Abstract Treatment strategies with a strong scientific rationale based on specific [...] Read more

San Antonio Pediatric Cancer Symposium

Published On: June 23, 2022
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San Antonio Pediatric Cancer Symposium (SAPCS) Feb 19-22, 2023 San Antonio Marriott Riverwalk 889 East Market Street, San Antonio, Texas, 78205 26 World-Class Childhood Cancer Experts 9 Robust Session Topics 4 Days 1 Objective On February 19-22, 2023, the San Antonio Pediatric Cancer Symposium (SAPCS), hosted by the Greehey Children’s Cancer Research Institute – UT [...] Read more