6:30pm – 8:30pm
Symposium Welcome Reception
7:30am – 8:30am
8:30am – 9:00am
William L Henrich, MD, MACP
President, UT Health San Antonio
Professor of Medicine
William L. Henrich, M.D., MACP, a specialist in kidney diseases, has served as the president of UT Health San Antonio since 2009. UT Health San Antonio is one of six health institutions under the umbrella of The University of Texas System.
UT Health is a dynamic and rapidly expanding health science center with five professional schools (medicine, nursing, dentistry, health professions, and graduate school of biomedical sciences) with education, clinical care, research, and community service missions. With a budget of nearly one billion dollars, a workforce of 7,100, and a research portfolio of approximately $300 million, UT Health is quickly rising in prominence among academic medical centers in the United States.
Henrich received his undergraduate degree from Columbia University and his medical degree from Baylor College of Medicine and later completed a residency in Internal Medicine at The University of Oregon Medical School and a fellowship in Nephrology at The University of Colorado School of Medicine.
During his career, Henrich has served as Professor of Medicine at The University of Texas Southwestern School of Medicine, as Professor and Chair of Medicine at the Medical College of Ohio, and as the Theodore Woodward Professor and Chairman of the Department of Medicine at The University of Maryland School of Medicine in Baltimore. He became the Dean of the School of Medicine and Vice President for Medical Affairs at UT Health San Antonio in 2006 prior to being selected as its President in 2009. He is the inaugural holder of the John P. Howe, III, M.D., Distinguished Chair in Health Policy.
He is the author of over 300 original articles and chapters and the founding editor of the popular dialysis textbook, “Henrich’s Principles and Practice of Dialysis”. His current areas of interest are in improving dialysis and vascular renal disease.
An elected member of several prominent research societies, Henrich also served as President of the American Society of Nephrology. He is passionate about mentoring students, residents, and young physicians and has received teaching accolades in every institution in which he has served.
Dean and Professor Long School of Medicine
Vice President for Medical Affairs
Dr. Hromas is the Dean at the Long School of Medicine and the Vice President for Medical Affairs at the University of Texas Health Center in San Antonio. The Long School of Medicine has over 1200 faculty, 880 medical students, and 865 residents and fellows and cares for 2 million patients annually. Prior to that, he was Chair of the Department of Medicine at the University of Florida Health, where he is also Vice President of the University of Florida Physicians Clinical Practice Association and a member of the UF Health Hospital Executive Board. He has personally trained 29 graduate students or fellows, most of which have entered academic careers, and 21 junior faculty, almost all of which have obtained tenure, with three obtaining Hematology-Oncology Division Chief Positions. He has served on the editorial boards of Blood and Stem Cells. He has won numerous teaching and patient care awards, including the Indiana University Humanism in Medical Education Award, the Indiana University Board of Trustees Outstanding Teacher Award, and the People Living Through Cancer Caring Award. He has served as Chair of Scientific Affairs for the American Society of Hematology and as their congressional and media representative. He has published over 170 research papers with an H-index of 55. He has been continuously funded by the National Institutes of Health for almost three decades and has chaired several NIH and American Cancer Society study sections. He has multiple patents and has started two biotechnology companies, both flourishing. His laboratory has isolated and characterized multiple novel cytokines and several DNA mutations leading to leukemia. He has identified several key components of DNA repair pathways. He created a drug development consortium at the University of Florida that translated University science to the clinic. He is the author of the business leadership book Einstein’s Boss- 10 Rules for Leading Genius. He was elected to the Liaison Committee on Medical Education, the accrediting body for US and Canadian medical schools. For these and other accomplishments, he has been elected to the American Society of Clinical Investigation, the Association of Professors of Medicine, the American Clinical and Climatologic Association, and the Association of American Physicians.
9:00am – 10:30am
Session 1: Targeted Therapy
Arvin Dar, PhD
Icahn School of Medicine at Mount Sinai
“Short-circuiting cancer pathways with chemical switches and molecular glues.”
About Dr. Dar: In the Dar laboratory, we study signal transduction networks at multiple levels: structurally, biochemically, within cells, and also within whole animals. A goal of the lab is to build the tools that will allow us to modulate signaling networks for mechanistic exploration of disease biology through to therapeutic applications. Our work is highly interdisciplinary, employing methods from synthetic organic chemistry, structural biology, mass spectrometry, informatics, biochemistry, and model organism genetics.
D.Will Parsons, PhD
Baylor College of Medicine
About Dr. Parsons: Dr. Will Parsons MD, PhD, is a board-certified pediatric oncologist and the Sidney L and Donald F. Faust Chair of Pediatric Cancer Precision Medicine at Texas Children’s Cancer and Hematology Center (Baylor College of Medicine, Houston, Texas). Dr. Parsons’ work has been instrumental in characterizing the genetic landscapes of a variety of pediatric and adult cancers, including the first identification of IDH1 and IDH2 as critical oncogenes in gliomas. His current research primarily focuses on the clinical application of genomic technologies in pediatric cancer care. Dr. Parsons has a particular interest in the development and evaluation of molecularly targeted therapies and has a number of leadership roles in this area, including serving as the Children’s Oncology Group (COG) study chair for the NCI-COG Pediatric MATCH trial (the first nationwide precision oncology trial for children with relapsed and refractory solid tumors, lymphomas, and histiocytoses) and as a Steering Committee member for the NIH Pediatric Early Phase Clinical Trials Network.
Angelina Vaseva, PhD
UT Health San Antonio
Targeting RAS in pediatric cancers- are we there yet?”
About Dr. Vaseva: Despite the high cure rates among children with cancer, following treatment with current multimodality therapies, survivors face profound lifelong therapy-related complications and the development of second malignancies, with increasing chronic, life-threatening toxicities as they age. In addition, the survival rate for many high-risk pediatric cancer patients has not improved significantly over the last 30 years. Hopes for the future depend on identifying novel therapies targeting specific cancer-driving cellular and molecular mechanisms, ensuring improved survival for high-risk patients, and providing a better quality of life for survivors. The focus of the Vaseva lab is to systematically define mechanisms of RAS and MAPK- driven vulnerabilities in pediatric cancers and design directions for novel targeted therapies.
10:30am – 11:00am
11:00am – 12:30pm
Session 2: Clinical Trials
Julia Glade-Bender, MD
Memorial Sloan Kettering
About Dr. Glade-Bender:
Julia Glade Bender, MD, is a pediatric oncologist and Vice Chairman for Clinical Research within the Department of Pediatrics at Memorial Sloan Kettering Cancer Center (MSK Kids). She has accumulated over 20 years of experience leading highly productive pediatric experimental therapeutics and early drug development programs. Her primary translational work has been on developing targeted agents for childhood solid tumors and the clinical implementation of precision oncology. She has provided the broad scientific leadership for early-phase clinical trials sponsored by the National Cancer Institute (NCI), the Children’s Oncology Group (COG), as well as smaller disease-oriented consortia and the pharmaceutical industry. She is a consultant to the Pediatric Oncologic Drugs Advisory Committee (ODAC) of the Food and Drug Administration (FDA), sits on the Steering Committee for the Pediatric NCI-MATCH (Pediatric Molecular Analysis for Therapy Choice), and currently serves as the COG Study Chair of the NCI-ComboMATCH.
Richard Gorlick, MD
About Dr. Gorlick: The research in my lab is focused on conducting translational studies aimed at improving outcomes for children, adolescents, and young adults with osteosarcoma, the most common primary malignant bone tumor in this patient population. Utilizing genomic and proteomic approaches, our lab identifies novel targets in osteosarcoma ripe for therapeutic intervention with the goal of developing new immunotherapies to be assessed in pre-clinical studies and clinical trials.
Brenda Weigel, PhD
Univ of Minnesota
About Dr. Weigel: Dr. Brenda Weigel is currently the Director of the Division of Pediatric Hematology/Oncology. She is a professor cross-appointed at the University of Minnesota’s Cancer Center and the Department of Pediatrics and the recipient of the Lehman/Children’s Cancer Research Fund Endowed Chair in Pediatric Cancer. She is also the Co-Director of the Sarcoma Program for the Masonic Cancer Center and an Associate Director of the Cancer Experimental Therapeutics Initiative for the Masonic Cancer Center.
12:30pm – 1:30pm
1:30pm – 3:00pm
Current Advances in Pediatric Solid Tumors Therapy
Patrick Grohar, MD, PhD
About Dr. Grohar: The goal of the Grohar lab is to develop effective targeted therapies for pediatric solid tumors. We believe in an integrated bench-to-bedside and back again approach that utilizes mechanistic pharmacology as a bridge between discovery science and the clinic. Our lab utilizes unbiased screens to identify novel targeted agents and drug combinations. We then focus on the mechanism of target suppression to identify novel combination therapies and translate the observations to the in vivo setting. Finally, we design clinical trials with pharmacokinetic/pharmacodynamic biomarkers of target suppression and correlative biology that further inform our preclinical studies.
Poul Sorensen, MD, PhD
Univ of British Columbia
About Dr. Sorenson: Dr. Sorensen is an internationally renowned expert in cancer biology and genetics, mRNA translation, and the use of biochemical and proteomic strategies to characterize deregulated signaling pathways in childhood and adult solid cancers. His group has discovered many genetic alterations in childhood cancer, including the EWS-ERG fusion in Ewing sarcoma, loss of the HACE1 tumor suppressor in Wilms’ tumor, and the ETV6-NTRK3 fusion in infantile fibrosarcoma and secretory breast carcinoma. The latter is the first description of NTRK fusions as recurrent drivers in human tumors, now thought to occur in >25 different human tumor types and in ~1% of human malignancies, leading to the development and worldwide approval of NTRK inhibitors for clinical use. His research utilizes biochemical methods including mRNA translational profiling and proteomic strategies to identify and characterize cell stress pathways that are deregulated in childhood and adult solid cancers.
Jason Yustein, MD, PhD
About Dr. Yustein: Our laboratory is dedicated to understanding mechanisms of metastasis and therapeutic resistance by using our experience integrating novel murine and patient-derived models with molecular approaches and functional genomic studies geared towards identifying new treatment avenues for the treatment of sarcomas.
3:30pm – 5:00pm
Session 4: Challenges in Immunology & Immunotherapy
Yael P. Mosse, PhD
About Dr. Mosse: The focus of Dr. Mossé’s lab research involves the genetic mutations responsible for neuroblastoma. The team recently discovered that a region of chromosome 2 was associated with the disease, and identified mutations in the anaplastic lymphoma kinase (ALK) gene. ALK is an oncogene (cancer-causing gene) with genetic and acquired mutations. Many pharmaceutical companies already make drugs that turn off the ALK gene, so Dr. Mossé’s team is now working on translating its discovery to the therapeutic use of ALK inhibiting drugs.
Julie Bailis, PhD
Presentation: “AMG 509, a STEAP1-Targeting T Cell Engager for Ewing Sarcoma.”
About Dr. Bailis: Julie Bailis, Ph.D., is an executive director at Amgen, Inc, where her team is focused on developing multispecific immune therapies, including T cell engager molecules. Julie obtained her PhD from Yale University and was a postdoctoral fellow at the Salk Institute for Biological Studies.
Manjeet Rao, PhD
UT Health San Antonio
About Dr. Rao: The overall goal of my laboratory is to develop more potent and less toxic drugs for treating adult and pediatric cancer patients. We have employed unbiased high throughput genomewide functional screens and small molecular screens to identify novel targets critical for growth, progression, and drug sensitivity in medulloblastoma and osteosarcoma. In particular, using the loss of function screens, we have identified key genes that play critical/causal roles in the growth and metastasis as well as in the chemo-sensitivity of osteosarcoma. Furthermore, by performing small molecule library screens, we have identified inhibitors of these proteins that may act as novel therapeutics for treating osteosarcoma.
Poster Previews & Poster Blast
(1min “elevator speech” of each poster)
Wine & Cheese Mixer
John M. Maris, MD
Presentation Title: Recent advances in the immunotherapeutic targeting of childhood cancer oncoproteins.
About Dr. Maris: Dr. John Maris is Giulio D’Angio Professor of Pediatrics in the Perelman School of Medicine at the University of Pennsylvania and the Children’s Hospital of Philadelphia. He is a physician-scientist who has focused for over three decades on childhood cancer neuroblastoma with the dual goals of improving patient outcomes and using the disease as a model to understand cancer in general. His group has discovered all the known neuroblastoma susceptibility genes and his group has also identified many of the oncogenic drivers of the disease. Dr. Maris has steadfastly sought to translate these discoveries to the clinic using precision medicine.
Over the last decade, he has led a multi-institutional St. Baldrick’s Foundation-Stand Up to Cancer Pediatric Cancer Dream Team project to bring the fields of genomics and immunology together to combat childhood cancers, and more recently a Beau Biden Moonshot Center Award to extend this rapidly evolving area of research. Dr. Maris is an internationally recognized practicing pediatric oncologist who cares for children with refractory neuroblastoma from around the world, typically in the context of early phase clinical trials.
Dr. Maris has been continuously funded by the National Institutes of Health and many other funding bodies. He currently holds a National Cancer Institute Outstanding Investigator Award and has received several prestigious awards including election into the American Society of Clinical Investigation, the Oski award for outstanding pediatric oncologists, the Berwick award at Penn for melding basic and clinical teaching, the William Osler Patient-Oriented Research Award at Penn, and the AACR 2021 Team Science Award for his leadership in pediatric immunoncology research.
Session 5: Big Data/Omics
Jinghui Zhang, PhD
Presentation Title: TBD
About Dr. Zhang: I am a computational biologist focused on the integrative analysis of large-scale, multi-dimensional genomic data to understand the initiation and progression of diseases. My research interest has been developing highly accurate and sensitive computational methods for analyzing large-scale genomic data, especially in detecting and analyzing genetic variations and somatic mutations.
Adam Resnick, PhD
About Dr. Resnick
Adam Resnick is the Director of Data-Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of accelerated discovery and clinical translation for all children. The D3b Center is comprised of a trans-disciplinary team that spans the clinical research unit, biospecimen research unit; molecular diagnostics research unit, pre-clinical research unit, bioinformatics unit, and translational imaging unit, and the advanced data applications and platform technologies unit.
Yang Xie, PhD
About Dr. Xie: Dr. Yang Xie received a BMedSc from Peking University Health Science Center in 2000 and a PhD in Biostatistics from the University of Minnesota in 2006. She is a Professor with a joint appointment in the Department of Population and Data Sciences and the Department of Bioinformatics at UT Southwestern Medical Center. Her research focuses on algorithm development, machine learning, and data integration for biomedical research. She is the founding director of the Quantitative Biomedical Research Center and the Pediatric Cancer Data Commons (PCDC) at UT Southwestern Medical Center. She is also a member of the NIH Biodata Management and Analysis Study Section [BDMA].
11:30am – 12noon
Short Talks from Submitted Abstracts
Format: 10min presentation + 5min Q&A
12noon – 1pm
1:00pm – 2:30pm
Session 6: Epigenetics/Transcriptional Dysregulation
Trever Bivona, MD, PhD
Presentation Title: TBD
About Dr. Bivona: I am a medical oncologist with a PhD in cell and molecular biology. I maintain an active academic clinical practice and lead a basic and translational research laboratory focused on cancer genetics, precision medicine, and the molecular basis of targeted therapy response and resistance. I have discovered several resistance mechanisms to EGFR-targeted therapy, BRAF- and MEK-targeted therapy, and ALK-targeted therapy in lung and other cancers. I direct a multi-disciplinary team engaged in laboratory-based patient-focused research. I am an investigator on clinical trials, including rational upfront polytherapy trials designed to forestall and eliminate resistance motivated by my laboratory-based discoveries.
Agata Smogorzewska, MD, PhD
About Dr. Smogorzewska: Using Fanconi anemia and other genetic diseases as a backdrop, Dr. Smogorzewska’s research aims to elucidate pathways that prevent stem cell dysfunction, and cancer development, with a focus on those that repair DNA. Throughout its lifetime, a cell’s DNA is under constant metabolic and environmental assault that can lead to damage. If left unchecked, the resulting genome instability can initiate cancer and a variety of other human disorders. Using Fanconi anemia and other genetic diseases as a backdrop, Smogorzewska’s research aims to elucidate the pathways that protect organ function and prevent cancer, with a focus on those that replicate and repair DNA.
Miguel N. Rivera, MD
Mass General Research Institute
Presentation Title: TBD
2:30pm – 3:00pm
Session 7: Disparities in Pediatric Cancer
Amelie G. Ramirez, Dr. P.H., M.P.H.
UT Health San Antonio
Exploring the Latino Cancer Burden in South Texas
About Dr. Ramirez: Dr. Amelie G. Ramirez is director of the Institute for Health Promotion Research (IHPR), chair of the Department of Population Health Sciences, and associate director of cancer outreach and engagement at the Mays Cancer Center, all at UT Health San Antonio. The IHPR, founded in 2006, investigates causes and solutions to cancer and chronic disease disparities to improve Latino health in San Antonio, South Texas, and the nation. The IHPR has a faculty and staff of researchers who specialize in population health, prevention and screening, and health promotion and communication on issues of obesity, cancer, tobacco, nutrition, physical activity, and more among Latino and underserved populations.
Phil Lupo, PhD
Baylor College of Medicine
Ethnic disparities in acute lymphoblastic leukemia susceptibility and outcomes.
About Dr. Lupo: Dr. Lupo is a Professor in the Department of Pediatrics at Baylor College of Medicine, Director of the Epidemiology and Population Sciences Program at Texas Children’s Cancer and Hematology Center, Chair of the Children’s Oncology Group (COG) Epidemiology Committee and has served in various capacities in the National Birth Defects Prevention Network (NBDPN), including President and Chair of the Data Committee. Dr. Lupo’s research is focused on characterizing susceptibility to pediatric cancer and limiting outcome disparities for children diagnosed with cancer.
4:00pm – 4:30pm
Short Talks from Submitted Abstracts
Format: 10min presentation + 5min Q&A
4:30pm – 5:30pm
Poster Session, Odd #s
5:30pm – 6:30pm
Poster Session, Even #s
6:30pm – 6:45pm
Ruben A. Mesa, MD, FACP
Executive Director, Mays Cancer Center at
UT Health San Antonio MD Anderson- An NCI Designated Cancer Center
Mays Family Foundation Distinguished University Presidential Chair
Professor of Medicine
Dr. Ruben Mesa is the executive director of Mays Cancer Center, home to UT Health San Antonio MD Anderson, one of only four National Cancer Institute-designated cancer centers in Texas. For almost 30 years the cancer center has had a deep focus on providing world-class cancer care, advancing cancer research, and educating the next generation of cancer care scientists and care providers.
Dr. Mesa’s practice builds on his role as an international expert on myeloproliferative neoplasms (MPNs), a group of bone marrow disorders that often lead to leukemia. He has been involved in MPN research for more than 20 years. He led the development of the National Comprehensive Cancer Network’s panel guidelines, the first U.S. guidelines on diagnosing and treating myelofibrosis, polycythemia vera, and essential thrombocythemia. Dr. Mesa has been the principal investigator or co-principal investigator of more than 70 clinical trials. He co-led the research team leading to the FDA’s approval of ruxolitinib for polycythemia vera and myelofibrosis. He is currently leading the investigation of several other drugs for these types of cancers. Dr. Mesa was elected to sit on the National Board of Directors for the Leukemia and Lymphoma Society and sits on the board of the MPN Education Foundation.
6:45pm – 8:00pm
Session 8: Transcription Factors, Structure to Function in Pediatric Cancer
Martin Eilers, PhD
Univ of Wurzburg
Presentation: “Sensing Aberrant Transcription by the MYCN Oncoprotein in Neuroblastoma”
About Dr. Eilers: Many cancers are life-threatening diseases, and there is an urgent need for novel therapeutic strategies. The Eilers lab works on the human MYC protein family, which is involved in the development of most human cancers. Our aim is both to understand the function of MYC proteins and explore new strategies to inhibit their function
Marcel Kool, PhD
Children’s Brain Tumor Network (Germany)
Presentation: Single-cell analyses of embryonal brain tumors provide new insights into cellular hierarchies, drug targets, and the tumor micro-environment.
Over the years, we got quite a good idea of what is driving most of these less frequent but often aggressive brain tumors, but there is still much to learn from further (epi)genomic analyses using state-of-the-art technologies, including, for instance also, single-cell omics, as the main drivers and/or therapeutic targets are not clearly defined in all tumors. Therefore, the aim is to characterize these better, identify clinically relevant and distinct molecular subgroups and the genes and pathways that drive them, and, most importantly, develop proper human and mouse model systems reflecting the different diseases and the inter-and intra-tumor heterogeneity. Additionally, we strive to find novel candidates for rational targeted therapies. We aim to translate knowledge obtained from these (epi)genomic studies into novel strategies for the most optimal treatments of patients.
Yasuyuki Ohkawa, Ph.D
- Development of epigenomic/transcriptomic technology
keyword: epigenome transcriptome technology
- Analysis of selective gene expression in organogenesis; keywords: epigenetics chromatin deep sequencer epigenome transcriptome
- Epigenetics Analysis in Stem Cell biology
keyword: epigenetics chromatin deep sequencer epigenome transcriptome
Current and Past Projects
- The analysis of Genomic re-organization in myogenesis