BMC Genomics: Robust inference of the context specific structure and temporal dynamics of gene regulatory network
Jia Meng, Mingzhu Lu, Yidong Chen, Shou-Jiang Gao & Yufei Huang
Abstract
Background
The response of cells to changing endogenous or exogenous conditions is governed by intricate molecular interactions or regulatory networks. To lead to appropriate responses, the regulatory network should be 1) context-specific, i.e., its constituents and topology depend on the phenotypical and experimental context including tissue types and cell conditions, such as damage, stress, macro environments of the cell, etc. and 2) time-varying, i.e., network elements and their regulatory roles change actively over time to control the endogenous cell states e.g. different stages in a cell cycle.
Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on childhood cancer by discovering, developing, and disseminating new scientific knowledge. Our mission consists of three key areas — research, clinical, and education.
Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.