BMC Genomics: Robust inference of the context specific structure and temporal dynamics of gene regulatory network

Background

The response of cells to changing endogenous or exogenous conditions is governed by intricate molecular interactions or regulatory networks. To lead to appropriate responses, the regulatory network should be 1) context-specific, i.e., its constituents and topology depend on the phenotypical and experimental context including tissue types and cell conditions, such as damage, stress, macro environments of the cell, etc. and 2) time-varying, i.e., network elements and their regulatory roles change actively over time to control the endogenous cell states e.g. different stages in a cell cycle.