Nature Communications: HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination (Wasmuth, Zheng, Sung Lab, Zhao)

August 12, 2026

Wenjing Li, Bo Wu, Boya Gao, Elizabeth M. Irvin, Arijit Ghosh, Lillian Eliaz, Yuxin Huang, Youngho Kwon, Clara M. Stiefel, Tram Thi Ngoc Nguyen, David Zhao, Humberto Javier Suarez, Tengyang Ni, Salvador Alejo, O’Taveon Fitzgerald, Xuemei Song, Sandip Kumar Rath, Elizabeth V. Wasmuth, David S. Yu, Siyuan Zheng, Justin Leung, Xiaoyu Xue, Hong Wang, Jae-Hoon [...]

Nature Communications: Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection (Sung Lab, Libich, Olsen, Wasmuth, Rao, et al)

July 22, 2026

Jeffrey N. Katz, Lorena Samentar, Qingming Fang, Jae-Hoon Ji, Wenjing Li, Qiongmei Gao, Sahiti Kuppa, Boya Gao, Cody M. Rogers, Hardeep Kaur, Aida Badamchi Shabestari, Arijit Dutta, Shahrez Syed, Miriam Tovar, Nozomi Tomimatsu, Bipasha Mukherjee, Elizabeth M. Irvin, Shuo Zhou, Amyn A. Habib, David S. Libich, Robert Hromas, Alexander V. Mazin, Manjeet K. Rao, Shaun [...]

Nature Communications: Break-induced replication forms long mutable single-strand DNA during meiosis (Malkova)

June 22, 2026

Thanks to advances in treatment, more than 85% of children diagnosed with cancer now survive into adulthood. However, many survivors face long-term health challenges caused by their cancer treatments, including heart disease, diabetes, high blood pressure, anxiety, depression, and reduced quality of life. In this study, researchers followed more than 18,000 childhood cancer survivors over [...]

Nature Structural & Molecular Biology: Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation (Sung Lab, Hromas, Zhou, Zhao, Wasmuth, Olsen)

June 5, 2026

Yashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rogers, Hardeep Kaur, Lorena Samentar, Weixing Zhao, Eloise Dray, Fang Zhang, Svetla Stoilova-McPhie, Alexander B. Taylor, [...]

Nature Communications: Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection (Sung, Rao, Olsen, Wasmuth, Zhao, Libich)

May 20, 2026

Jeffrey N. Katz, Lorena Samentar, Qingming Fang, Jae-Hoon Ji, Wenjing Li, Qiongmei Gao, Sahiti Kuppa, Boya Gao, Cody M. Rogers, Hardeep Kaur, Aida Badamchi Shabestari, Arijit Dutta, Shahrez Syed, Miriam Tovar, Nozomi Tomimatsu, Bipasha Mukherjee, Elizabeth M. Irvin, Shuo Zhou, Amyn A. Habib, David S. Libich, Robert Hromas, Alexander V. Mazin, Manjeet K. Rao, Shaun [...]

Nature Communications: Highly mutagenic copying of telomeric circles promotes ALT establishment (Malkova Lab)

May 5, 2026

Meng-Chia Tsai, Jacob M. Wells, Kelley A. Renninger, Kendra Musmaker, Ryan Pellow, Andrey Malkov, Josep M. Comeron & Anna Malkova Abstract Alternative lengthening of telomeres (ALT) is a recombination-based pathway that enables cancer cells to maintain telomere length. ALT establishment remains poorly understood due to difficulties in identifying its molecular steps. Here, using Oxford Nanopore sequencing [...]

Nature Structural & Molecular Biology: Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation (Rao, Libich, Wasmuth, Sung, Olsen et al)

April 24, 2026

Yashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rogers, Hardeep Kaur, Lorena Samentar, Weixing Zhao, Eloise Dray, Fang Zhang, Svetla Stoilova-McPhie, Alexander B. Taylor, [...]

Science Advances: Selective elimination of circulating effector CD8 T cells via LTβR blockade separates anti-CD137 efficacy from toxicity (Lai, Chen)

April 24, 2026

Sergey A. Shein  Anna A. Korchagina  Li-Ju Wang Zhao Lai, Yidong Chen  Jacob S. Fisher  Burkhard Ludewig Jessica N. Lancaster  Yang-Xin Fu , Ekaterina Koroleva and Alexei V. Tumanov Abstract The major barrier to clinical translation of αCD137 immunotherapy is separating antitumor efficacy from hepatotoxicity driven by IFN-γ–producing CD8 T cells. We propose a strategy to limit toxicity by promoting contraction of excessively expanded CD8 T cells. We identify [...]

Nature Structural & Molecular Biology: Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex (Sung Lab, Rao Lab)

April 1, 2026

Abstract Senataxin (SETX), an RNA–DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX–BRCA1 resolves transcription-associated R-loops to prevent deleterious outcomes. Specifically, we show that full-length SETX unwinds R-loops with broad specificity and that the complex of BRCA1 and its obligatory partner BARD1 binds R-loops [...]

Cancer Research: Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity (Rao, Zhou, Hromas, Sung, Chen, et al)

December 3, 2025

Deepika Singh Benjamin C. Onyeagucha Daisy Medina Panneerdoss Subbarayalu Rahul Mojidra Dongwen Lv Mukund Bhandari Santosh Timilsina Prabhakar Pitta Venkata Jian Yu. Huang Saif Nirzhor Shahad Abdulsahib Jack Yancy. Prochnau Chris TP. Do Subapriya Rajamanickam Yidong Chen Alexander B. Taylor Suryavathi Viswanadhapalli Maria E. Falzone Jean Jiang Patrick Sung Daohong Zhou Abstract Approaches targeting factors [...]