Greehey Children's Cancer Research Institute
Category
September 1, 2026
Every time a cell divides, it has to copy billions of pieces of DNA. It is an incredibly complicated process, and mistakes or damage are inevitable. Healthy cells have several ways to fix those problems before they become dangerous. Cancer cells do, too. In a new study published in Nucleic Acids Research, researchers from UT [...]August 12, 2026
Wenjing Li, Bo Wu, Boya Gao, Elizabeth M. Irvin, Arijit Ghosh, Lillian Eliaz, Yuxin Huang, Youngho Kwon, Clara M. Stiefel, Tram Thi Ngoc Nguyen, David Zhao, Humberto Javier Suarez, Tengyang Ni, Salvador Alejo, O’Taveon Fitzgerald, Xuemei Song, Sandip Kumar Rath, Elizabeth V. Wasmuth, David S. Yu, Siyuan Zheng, Justin Leung, Xiaoyu Xue, Hong Wang, Jae-Hoon [...]July 22, 2026
Jeffrey N. Katz, Lorena Samentar, Qingming Fang, Jae-Hoon Ji, Wenjing Li, Qiongmei Gao, Sahiti Kuppa, Boya Gao, Cody M. Rogers, Hardeep Kaur, Aida Badamchi Shabestari, Arijit Dutta, Shahrez Syed, Miriam Tovar, Nozomi Tomimatsu, Bipasha Mukherjee, Elizabeth M. Irvin, Shuo Zhou, Amyn A. Habib, David S. Libich, Robert Hromas, Alexander V. Mazin, Manjeet K. Rao, Shaun [...]June 22, 2026
Thanks to advances in treatment, more than 85% of children diagnosed with cancer now survive into adulthood. However, many survivors face long-term health challenges caused by their cancer treatments, including heart disease, diabetes, high blood pressure, anxiety, depression, and reduced quality of life. In this study, researchers followed more than 18,000 childhood cancer survivors over [...]June 5, 2026
Yashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rogers, Hardeep Kaur, Lorena Samentar, Weixing Zhao, Eloise Dray, Fang Zhang, Svetla Stoilova-McPhie, Alexander B. Taylor, [...]May 20, 2026
Jeffrey N. Katz, Lorena Samentar, Qingming Fang, Jae-Hoon Ji, Wenjing Li, Qiongmei Gao, Sahiti Kuppa, Boya Gao, Cody M. Rogers, Hardeep Kaur, Aida Badamchi Shabestari, Arijit Dutta, Shahrez Syed, Miriam Tovar, Nozomi Tomimatsu, Bipasha Mukherjee, Elizabeth M. Irvin, Shuo Zhou, Amyn A. Habib, David S. Libich, Robert Hromas, Alexander V. Mazin, Manjeet K. Rao, Shaun [...]May 5, 2026
Meng-Chia Tsai, Jacob M. Wells, Kelley A. Renninger, Kendra Musmaker, Ryan Pellow, Andrey Malkov, Josep M. Comeron & Anna Malkova Abstract Alternative lengthening of telomeres (ALT) is a recombination-based pathway that enables cancer cells to maintain telomere length. ALT establishment remains poorly understood due to difficulties in identifying its molecular steps. Here, using Oxford Nanopore sequencing [...]April 24, 2026
Yashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rogers, Hardeep Kaur, Lorena Samentar, Weixing Zhao, Eloise Dray, Fang Zhang, Svetla Stoilova-McPhie, Alexander B. Taylor, [...]April 24, 2026
Sergey A. Shein Anna A. Korchagina Li-Ju Wang Zhao Lai, Yidong Chen Jacob S. Fisher Burkhard Ludewig Jessica N. Lancaster Yang-Xin Fu , Ekaterina Koroleva and Alexei V. Tumanov Abstract The major barrier to clinical translation of αCD137 immunotherapy is separating antitumor efficacy from hepatotoxicity driven by IFN-γ–producing CD8 T cells. We propose a strategy to limit toxicity by promoting contraction of excessively expanded CD8 T cells. We identify [...]April 1, 2026
Abstract Senataxin (SETX), an RNA–DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX–BRCA1 resolves transcription-associated R-loops to prevent deleterious outcomes. Specifically, we show that full-length SETX unwinds R-loops with broad specificity and that the complex of BRCA1 and its obligatory partner BARD1 binds R-loops [...]