IF 10+ Archives - Greehey Children's Cancer

Nature Structural & Molecular Biology: Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation (Sung Lab, Hromas, Zhou, Zhao, Wasmuth, Olsen)

June 5, 2026
Yashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rogers, Hardeep Kaur, Lorena Samentar, Weixing Zhao, Eloise Dray, Fang Zhang, Svetla Stoilova-McPhie, Alexander B. Taylor, [...]

Nature Communications: Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection (Sung, Rao, Olsen, Wasmuth, Zhao, Libich)

May 20, 2026
Jeffrey N. Katz, Lorena Samentar, Qingming Fang, Jae-Hoon Ji, Wenjing Li, Qiongmei Gao, Sahiti Kuppa, Boya Gao, Cody M. Rogers, Hardeep Kaur, Aida Badamchi Shabestari, Arijit Dutta, Shahrez Syed, Miriam Tovar, Nozomi Tomimatsu, Bipasha Mukherjee, Elizabeth M. Irvin, Shuo Zhou, Amyn A. Habib, David S. Libich, Robert Hromas, Alexander V. Mazin, Manjeet K. Rao, Shaun [...]

Nature Communications: Highly mutagenic copying of telomeric circles promotes ALT establishment (Malkova Lab)

May 5, 2026
Meng-Chia Tsai, Jacob M. Wells, Kelley A. Renninger, Kendra Musmaker, Ryan Pellow, Andrey Malkov, Josep M. Comeron & Anna Malkova Abstract Alternative lengthening of telomeres (ALT) is a recombination-based pathway that enables cancer cells to maintain telomere length. ALT establishment remains poorly understood due to difficulties in identifying its molecular steps. Here, using Oxford Nanopore sequencing [...]

Nature Structural & Molecular Biology: Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation (Rao, Libich, Wasmuth, Sung, Olsen et al)

April 24, 2026
Yashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rogers, Hardeep Kaur, Lorena Samentar, Weixing Zhao, Eloise Dray, Fang Zhang, Svetla Stoilova-McPhie, Alexander B. Taylor, [...]

Science Advances: Selective elimination of circulating effector CD8 T cells via LTβR blockade separates anti-CD137 efficacy from toxicity (Lai, Chen)

April 24, 2026
Sergey A. Shein Anna A. Korchagina Li-Ju Wang Zhao Lai, Yidong Chen Jacob S. Fisher Burkhard Ludewig Jessica N. Lancaster Yang-Xin Fu , Ekaterina Koroleva and Alexei V. Tumanov Abstract The major barrier to clinical translation of αCD137 immunotherapy is separating antitumor efficacy from hepatotoxicity driven by IFN-γ–producing CD8 T cells. We propose a strategy to limit toxicity by promoting contraction of excessively expanded CD8 T cells. We identify [...]

Nature Structural & Molecular Biology: Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex (Sung Lab, Rao Lab)

April 1, 2026
Abstract Senataxin (SETX), an RNA–DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX–BRCA1 resolves transcription-associated R-loops to prevent deleterious outcomes. Specifically, we show that full-length SETX unwinds R-loops with broad specificity and that the complex of BRCA1 and its obligatory partner BARD1 binds R-loops [...]

Cancer Research: Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity (Rao, Zhou, Hromas, Sung, Chen, et al)

December 3, 2025
Deepika Singh Benjamin C. Onyeagucha Daisy Medina Panneerdoss Subbarayalu Rahul Mojidra Dongwen Lv Mukund Bhandari Santosh Timilsina Prabhakar Pitta Venkata Jian Yu. Huang Saif Nirzhor Shahad Abdulsahib Jack Yancy. Prochnau Chris TP. Do Subapriya Rajamanickam Yidong Chen Alexander B. Taylor Suryavathi Viswanadhapalli Maria E. Falzone Jean Jiang Patrick Sung Daohong Zhou Abstract Approaches targeting factors [...]

Cancer Research: Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity (Rao, Zhou, Hromas, Sung, Chen

Molecular Cell: Deubiquitinases cleave ubiquitin-fused ribosomal proteins and physically counteract their targeting to the UFD pathway (Olsen)

December 1, 2025
Stephanie Patchett 1 5, Seyed Arad Moghadasi 1 5, Ankita Shukla 2, Farid El Oualid 3, Beatrix M. Ueberheide 1 4, Shaun K. Olsen 2, Tony T. Huang 1 6 Highlights Cleavage-resistant ubiquitin-fused human ribosomal proteins (RPs) impair ribosome function Unprocessed, Ub-fused RPs are targeted for proteasomal degradation by the UFD pathway DUB activity-based probes for Ub-fused RPs identify Cezanne/OTUD7B and other DUBs Catalytic activity-independent DUB association with Ub-RPs prevents their degradation Summary In eukaryotes, each ribosomal subunit includes [...]

Nature Structural & Molecular Biology: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer (Olsen Lab, Sung Lab)

September 26, 2025
Anindita Nayak, Digant Nayak, Lijia Jia, Eliza A. Ruben, Suryavathi Viswanadhapalli, Priscila dos Santos Bury, Khaled Mohamed Nassar, Corey H. Yu, Anna A. Tumanova, Caleb M. Stratton, Pirouz Ebadi, Dmitri N. Ivanov, Patrick Sung, Ratna K. Vadlamudi, Elizabeth V. Wasmuth & Shaun K. Olsen Abstract Post-translational modification of proteins by SUMO (small ubiquitin-like modifier) regulates fundamental [...]