Category
April 6, 2020
Originally Published, Pipette Gazette: By: Brian Iskra, The pandemic of COVID-19 is a challenging situation for every member of society; we all have our role to play in mitigating the mortality caused by the infection. Medical professionals are at the heart of our efforts to prevent a large number of our population from being lost […]
April 3, 2020
Milad Mostavi, Yu-Chiao Chiu, Yufei Huang & Yidong Chen Abstract Background Precise prediction of cancer types is vital for cancer diagnosis and therapy. Through a predictive model, important cancer marker genes can be inferred. Several studies have attempted to build machine learning models for this task however none has taken into consideration the effects of tissue of origin that can […]
March 27, 2020
Peter M LoCoco 1, Jacob T Boyd 1, Claudia M Espitia Olaya 2, Ashley R Furr 1, Dawn K Garcia 3, Korri S Weldon 3, Yi Zou 3, Erin Locke 1, Alejandro Tobon 4, Zhao Lai 3 5, Shivani B Ruparel 1, Nikita B Ruparel 1, Kenneth M Hargreaves 1 Abstract Introduction: Comprehensive mRNA sequencing is a powerful tool for conducting unbiased, quantitative differential gene expression analysis. However, the reliability of these data is contingent on the extraction of high-quality RNA from […]
March 16, 2020
Overview: Centromeres are essential for chromosome segregation during mitosis. The kinetochore is the protein complex associated with the centromere. Dysfunction in centromeres causes chromosome instability and can result in aneuploidy. The overall goal of our research is to understand the mechanisms that help maintain centromere function. Centromere identity does not rely on specific DNA sequences, […]
March 4, 2020
Abstract Cardiac non-myocytes comprise a diverse and crucial cell population in the heart that plays dynamic roles in cardiac wound healing and growth. Non-myocytes broadly fall into four cell types: endothelium, fibroblasts, leukocytes, and pericytes. Here we characterize the diversity of the non-myocytes in vivo and in vitro using mass cytometry. By leveraging single-cell RNA […]
March 1, 2020
Shaofang Wu 1, Feng Gao 1, Siyuan Zheng 2, Chen Zhang 1, Emmanuel Martinez-Ledesma 1 3, Ravesanker Ezhilarasan 4, Jie Ding 1, Xiaolong Li 1, Ningping Feng 5, Asha Multani 6, Erik P Sulman 4, Roel G Verhaak 2, John F de Groot 1, Tim P Heffernan 5, W K Alfred Yung 1, Dimpy Koul 7 Abstract Purpose: Exploration of novel strategies to extend the benefit of PARP inhibitors beyond BRCA-mutant cancers is of great interest in personalized medicine. Here, we identified EGFR amplification as a potential biomarker to predict sensitivity […]
February 27, 2020
CPRIT officials said this is one of the largest amounts San Antonio institutions have collectively received from the institute in a single funding round since it was established by Texas voters in 2007. CPRIT CEO Wayne Roberts said it’s also further indication that the Alamo City “continues to expand its cancer research and prevention prowess.”
February 24, 2020
Paige Baldwin1, Rostislav Likhotvorik2, Nabeela Baig2, Jodie Cropper2, Ruth Carlson2, Raushan Kurmasheva2,3*† and Srinivas Sridhar1,4,5*† The Pediatric Preclinical Testing Program previously identified the PARP inhibitor talazoparib (TLZ) as a means to potentiate temozolomide (TMZ) activity for the treatment of Ewing sarcoma. However, the combination of TLZ and TMZ has been toxic in both preclinical and clinical […]
February 20, 2020
Kevin Kanda made a promise to his family to try to fight cancer. “I’ve lost some family and friends to cancer….my uncle died from lymphoma and I’ve known people with pancreatic and breast cancer as well,” he said. Initially, Kanda thought nursing would be a good option for him. He tried nursing school for a […]